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    NOT5 CCR4-NOT core subunit NOT5 [ Saccharomyces cerevisiae S288C ]

    Gene ID: 856186, updated on 18-Sep-2024

    Summary

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    Official Symbol
    NOT5
    Official Full Name
    CCR4-NOT core subunit NOT5
    Primary source
    SGD:S000006276
    Locus tag
    YPR072W
    See related
    AllianceGenome:SGD:S000006276; FungiDB:YPR072W; VEuPathDB:YPR072W
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Summary
    Involved in several processes, including nuclear-transcribed mRNA catabolic process; positive regulation of transcription elongation from RNA polymerase II promoter; and transcription elongation from RNA polymerase II promoter. Located in cytoplasm. Part of CCR4-NOT core complex. Orthologous to human CNOT3 (CCR4-NOT transcription complex subunit 3). [provided by Alliance of Genome Resources, Apr 2022]
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    Genomic context

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    See NOT5 in Genome Data Viewer
    Location:
    chromosome: XVI
    Exon count:
    1
    Sequence:
    Chromosome: XVI; NC_001148.4 (690107..691789)

    Chromosome XVI - NC_001148.4Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene tRNA-Ser Neighboring gene tyrosine protein phosphatase LTP1 Neighboring gene transketolase TKL1

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001148.4

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Not4 and Not5 modulate translation elongation by Rps7A ubiquitination, Rli1 moonlighting, and condensates that exclude eIF5A. Allen GE, et al. Cell Rep, 2021 Aug 31. PMID 34469733
    2. The yeast EDC1 mRNA undergoes deadenylation-independent decapping stimulated by Not2p, Not4p, and Not5p. Muhlrad D, et al. EMBO J, 2005 Mar 9. PMID 15706350, Free PMC Article
    3. Ccr4-not complex mRNA deadenylase activity contributes to DNA damage responses in Saccharomyces cerevisiae. Traven A, et al. Genetics, 2005 Jan. PMID 15466434, Free PMC Article
    4. Characterization of NOT5 that encodes a new component of the Not protein complex. Oberholzer U, et al. Gene, 1998 Jan 19. PMID 9511744
    5. Loss of the SUMO protease Ulp2 triggers a specific multichromosome aneuploidy. Ryu HY, et al. Genes Dev, 2016 Aug 15. PMID 27585592, Free PMC Article

    See all (89) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Not4 and Not5 modulate translation elongation by Rps7A ubiquitination, Rli1 moonlighting, and condensates that exclude eIF5A.
      Title: Not4 and Not5 modulate translation elongation by Rps7A ubiquitination, Rli1 moonlighting, and condensates that exclude eIF5A.
    2. Not5-dependent co-translational assembly of Ada2 and Spt20 is essential for functional integrity of SAGA histone acetyltransferase complexes. SAGA mRNAs encoding a core set of SAGA subunits are tethered together for co-translational assembly of the encoded proteins.
      Title: Not5-dependent co-translational assembly of Ada2 and Spt20 is essential for functional integrity of SAGA.
    3. Hence taken together our results show that Not5 interconnects translation and transcription.
      Title: The Not5 subunit of the ccr4-not complex connects transcription and translation.
    4. Not2 and Not5 have extended regions that wrap around Not1 and around their globular domains, the Not boxes.
      Title: Structure and RNA-binding properties of the Not1-Not2-Not5 module of the yeast Ccr4-Not complex.
    5. Not4 is required for appropriate association of the Not5 subunit of the Ccr4-Not complex with polysomes and for ubiquitination of Rps7A.
      Title: Presence of Not5 and ubiquitinated Rps7A in polysome fractions depends upon the Not4 E3 ligase.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in deadenylation-dependent decapping of nuclear-transcribed mRNA IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in deadenylation-independent decapping of nuclear-transcribed mRNA IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in nuclear-transcribed mRNA poly(A) tail shortening IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in nuclear-transcribed mRNA poly(A) tail shortening IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in nuclear-transcribed mRNA poly(A) tail shortening IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in positive regulation of transcription elongation by RNA polymerase II IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in protein ubiquitination IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in regulation of DNA-templated transcription IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in transcription elongation by RNA polymerase II IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    part_of CCR4-NOT core complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of CCR4-NOT core complex IEA
    Inferred from Electronic Annotation
    more info
    		  
    part_of CCR4-NOT core complex IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    is_active_in P-body IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytoplasm IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    CCR4-NOT core subunit NOT5
    NP_015397.1
    • Component of the CCR4-NOT core complex, involved in mRNA decapping; involved intranscription initiation and elongation and in mRNA degradation; conserved lysine in human homolog of Not5p and Not3p is mutated in cancers

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001148.4 Reference assembly

      Range
      690107..691789
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001184169.1 → NP_015397.1  TPA: CCR4-NOT core subunit NOT5 [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_015397.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D6W476, Q12514
      UniProtKB/TrEMBL
      A6ZWV9, B3LLC5, B5VTL9, C7GXZ8, G2WPP4, N1P269
      Conserved Domains (1) summary
      COG5665
      Location:11 → 560
      COG5665; CCR4-NOT transcriptional regulation complex, NOT5 subunit [Transcription]
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q12514.1

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