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    TKL1 transketolase TKL1 [ Saccharomyces cerevisiae S288C ]

    Gene ID: 856188, updated on 18-Sep-2024

    Summary

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    Official Symbol
    TKL1
    Official Full Name
    transketolase TKL1
    Primary source
    SGD:S000006278
    Locus tag
    YPR074C
    See related
    AllianceGenome:SGD:S000006278; FungiDB:YPR074C; VEuPathDB:YPR074C
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Summary
    Enables transketolase activity. Involved in pentose-phosphate shunt. Predicted to be located in cytoplasm. Predicted to be active in cytosol and nucleus. Orthologous to several human genes including TKT (transketolase) and TKTL2 (transketolase like 2). [provided by Alliance of Genome Resources, Apr 2022]
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    Genomic context

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    See TKL1 in Genome Data Viewer
    Location:
    chromosome: XVI
    Exon count:
    1
    Sequence:
    Chromosome: XVI; NC_001148.4 (692796..694838, complement)

    Chromosome XVI - NC_001148.4Genomic Context describing neighboring genes Neighboring gene CCR4-NOT core subunit NOT5 Neighboring gene tyrosine protein phosphatase LTP1 Neighboring gene Opy2p Neighboring gene uncharacterized protein

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001148.4

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Complementary function of two transketolase isoforms from Moniliella megachiliensis in relation to stress response. Iwata H, et al. AMB Express, 2017 Dec. PMID 28224439, Free PMC Article
    2. Structure and functioning mechanism of transketolase. Kochetov GA, et al. Biochim Biophys Acta, 2014 Sep. PMID 24929114
    3. Halogenated pyruvate derivatives as substrates of transketolase from Saccharomyces cerevisiae. Esakova OA, et al. Biochemistry (Mosc), 2009 Nov. PMID 19916939
    4. Effects of transketolase cofactors on its conformation and stability. Esakova OA, et al. Life Sci, 2005 Nov 19. PMID 16125202
    5. Binding of the coenzyme and formation of the transketolase active center. Kochetov G, et al. IUBMB Life, 2005 Jul. PMID 16081370

    See all (117) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Transketolase is the key rate-limiting enzyme of the non-oxidative branch of the pentose phosphate pathway of carbohydrate transformation. (Review)
      Title: Structure and functioning mechanism of transketolase.
    2. characterization of NQM1 and TKL2, together with TAL1 and TKL1, regarding their roles in xylose utilization and fermentation
      Title: Characterization of non-oxidative transaldolase and transketolase enzymes in the pentose phosphate pathway with regard to xylose utilization by recombinant Saccharomyces cerevisiae.
    3. Halogenated pyruvate derivatives can function as donor substrates of transketolase.
      Title: Halogenated pyruvate derivatives as substrates of transketolase from Saccharomyces cerevisiae.
    4. In the presence of Ca2+, the active sites of TK1 and TK2 exhibit negative cooperativity in binding both xylulose-5-phosphate and ribose-5-phosphate and positive cooperativity in the catalytic transformation of the substrates.
      Title: Cooperative binding of substrates to transketolase from Saccharomyces cerevisiae.
    5. Review summarizes the results of studies on the kinetics of the interaction of thiamine diphosphate with transketolase and the generation of the catalytically active form of the coenzyme within the holoenzyme and formation of the enzyme's active center.
      Title: Binding of the coenzyme and formation of the transketolase active center.
    6. transketolase is regulated by donor substrates
      Title: Donor substrate regulation of transketolase.
    Submit: New GeneRIF Correction

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables transferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables transketolase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables transketolase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables transketolase activity IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in pentose-phosphate shunt IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in pentose-phosphate shunt IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in cytoplasm IC
    Inferred by Curator
    more info
    		 PubMed 
    is_active_in cytosol IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    transketolase TKL1
    NP_015399.1
    • Transketolase; catalyzes conversion of xylulose-5-phosphate and ribose-5-phosphate to sedoheptulose-7-phosphate and glyceraldehyde-3-phosphate in the pentose phosphate pathway; needed for synthesis of aromatic amino acids; TKL1 has a paralog, TKL2, that arose from the whole genome duplication

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001148.4 Reference assembly

      Range
      692796..694838 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001184171.1 → NP_015399.1  TPA: transketolase TKL1 [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_015399.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D6W478, P23254
      UniProtKB/TrEMBL
      A0A387JUB2, A6ZWW1, B5VTM0, C7GY00, G2WPP6, N1NXM0
      Conserved Domains (1) summary
      TIGR00232
      Location:9 → 664
      tktlase_bact; transketolase, bacterial and yeast
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P23254.4

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