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    RPN7 proteasome regulatory particle lid subunit RPN7 [ Saccharomyces cerevisiae S288C ]

    Gene ID: 856223, updated on 29-Jun-2024

    Summary

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    Gene symbol
    RPN7
    Gene description
    proteasome regulatory particle lid subunit RPN7
    Primary source
    FungiDB:YPR108W
    Locus tag
    YPR108W
    See related
    SGD:S000006312; AllianceGenome:SGD:S000006312; VEuPathDB:YPR108W
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Summary
    Enables structural molecule activity. Predicted to be involved in proteasome-mediated ubiquitin-dependent protein catabolic process. Located in nucleus. Part of proteasome regulatory particle, lid subcomplex. Orthologous to human PSMD6 (proteasome 26S subunit, non-ATPase 6). [provided by Alliance of Genome Resources, Apr 2022]
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    Genomic context

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    See RPN7 in Genome Data Viewer
    Location:
    chromosome: XVI
    Exon count:
    1
    Sequence:
    Chromosome: XVI; NC_001148.4 (742454..743743)

    Chromosome XVI - NC_001148.4Genomic Context describing neighboring genes Neighboring gene putative protein kinase ISR1 Neighboring gene cleavage polyadenylation factor RNA-binding subunit YTH1 Neighboring gene tRNA-Thr Neighboring gene Gld1p

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001148.4

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. The assembly pathway of the 19S regulatory particle of the yeast 26S proteasome. Isono E, et al. Mol Biol Cell, 2007 Feb. PMID 17135287, Free PMC Article
    2. Expanded Coverage of the 26S Proteasome Conformational Landscape Reveals Mechanisms of Peptidase Gating. Eisele MR, et al. Cell Rep, 2018 Jul 31. PMID 30067984, Free PMC Article
    3. Localization of the regulatory particle subunit Sem1 in the 26S proteasome. Bohn S, et al. Biochem Biophys Res Commun, 2013 May 31. PMID 23643786
    4. Rpn7 Is required for the structural integrity of the 26 S proteasome of Saccharomyces cerevisiae. Isono E, et al. J Biol Chem, 2004 Jun 25. PMID 15102831
    5. Unified nomenclature for subunits of the Saccharomyces cerevisiae proteasome regulatory particle. Finley D, et al. Trends Biochem Sci, 1998 Jul. PMID 9697412

    See all (108) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables structural molecule activity IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in proteasome-mediated ubiquitin-dependent protein catabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in proteasome-mediated ubiquitin-dependent protein catabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in ubiquitin-dependent protein catabolic process TAS
    Traceable Author Statement
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    part_of proteasome complex IEA
    Inferred from Electronic Annotation
    more info
    		  
    part_of proteasome regulatory particle IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of proteasome regulatory particle, lid subcomplex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    part_of proteasome regulatory particle, lid subcomplex IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    proteasome regulatory particle lid subunit RPN7
    NP_015433.1
    • Essential non-ATPase regulatory subunit of the 26S proteasome; similar to another S. cerevisiae regulatory subunit, Rpn5p, as well as to mammalian proteasome subunits

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001148.4 Reference assembly

      Range
      742454..743743
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001184205.1 → NP_015433.1  TPA: proteasome regulatory particle lid subunit RPN7 [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_015433.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D6W4A6, E9P8W9, Q06103
      UniProtKB/TrEMBL
      A0A6A5Q2N6, A6ZWY8, B3LK72, B5VTP8, C7GXR9, C8ZJC9, N1NVL0
      Conserved Domains (1) summary
      COG5187
      Location:2 → 429
      RPN7; 26S proteasome regulatory complex component, contains PCI domain [Posttranslational modification, protein turnover, chaperones]
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q06103.3

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