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    YLH47 Ylh47p [ Saccharomyces cerevisiae S288C ]

    Gene ID: 856243, updated on 9-Jun-2024

    Summary

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    Gene symbol
    YLH47
    Gene description
    Ylh47p
    Primary source
    FungiDB:YPR125W
    Locus tag
    YPR125W
    See related
    SGD:S000006329; AllianceGenome:SGD:S000006329; VEuPathDB:YPR125W
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Also known as
    MRS7
    Summary
    Predicted to enable ribosome binding activity. Involved in potassium ion transport; protein insertion into mitochondrial inner membrane from matrix; and proton transmembrane transport. Located in mitochondrial inner membrane. Orthologous to several human genes including LETM1 (leucine zipper and EF-hand containing transmembrane protein 1). [provided by Alliance of Genome Resources, Apr 2022]
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    Genomic context

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    See YLH47 in Genome Data Viewer
    Location:
    chromosome: XVI
    Exon count:
    1
    Sequence:
    Chromosome: XVI; NC_001148.4 (787961..789325)

    Chromosome XVI - NC_001148.4Genomic Context describing neighboring genes Neighboring gene Axl1p Neighboring gene high-affinity Cu transporter CTR1 Neighboring gene pyridoxine 4-dehydrogenase Neighboring gene Ant1p

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001148.4

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. The LETM1/YOL027 gene family encodes a factor of the mitochondrial K+ homeostasis with a potential role in the Wolf-Hirschhorn syndrome. Nowikovsky K, et al. J Biol Chem, 2004 Jul 16. PMID 15138253
    2. Ribosome-binding proteins Mdm38 and Mba1 display overlapping functions for regulation of mitochondrial translation. Bauerschmitt H, et al. Mol Biol Cell, 2010 Jun 15. PMID 20427570, Free PMC Article
    3. Novel components of an active mitochondrial K(+)/H(+) exchange. Zotova L, et al. J Biol Chem, 2010 May 7. PMID 20197279, Free PMC Article
    4. Mdm38 interacts with ribosomes and is a component of the mitochondrial protein export machinery. Frazier AE, et al. J Cell Biol, 2006 Feb 13. PMID 16476776, Free PMC Article
    5. Ubiquitination screen using protein microarrays for comprehensive identification of Rsp5 substrates in yeast. Gupta R, et al. Mol Syst Biol, 2007. PMID 17551511, Free PMC Article

    See all (35) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. The function of YLH47 was analyzed.
      Title: Mdm38 interacts with ribosomes and is a component of the mitochondrial protein export machinery.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables molecular_function ND
    No biological Data available
    more info
    		  
    enables ribosome binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in intracellular monoatomic cation homeostasis IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in potassium ion transport IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in protein insertion into mitochondrial inner membrane from matrix IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in proton transmembrane transport IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in mitochondrial inner membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in mitochondrial inner membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in mitochondrion HDA PubMed 
    located_in mitochondrion IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    Ylh47p
    NP_015450.1
    • Mitochondrial inner membrane protein; exposed to the mitochondrial matrix; associates with mitochondrial ribosomes; NOT required for respiratory growth; homolog of human Letm1, a protein implicated in Wolf-Hirschhorn syndrome

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001148.4 Reference assembly

      Range
      787961..789325
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001184222.1 → NP_015450.1  TPA: Ylh47p [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_015450.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D6W4C3, P89103, Q06493
      UniProtKB/TrEMBL
      A0A8H4BWH6, A6ZX05, B3LK88, B5VTR5, C7GLI7, C8ZJE7, N1NWH6
      Conserved Domains (1) summary
      pfam07766
      Location:82 → 343
      LETM1; LETM1-like protein
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q06493.1

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