ZFAND6 zinc finger AN1-type containing 6 [Homo sapiens (human)] - Gene

Summary

Official Symbol: ZFAND6provided by HGNC
Official Full Name: zinc finger AN1-type containing 6provided by HGNC
Primary source: HGNC:HGNC:30164
See related: Ensembl:ENSG00000086666 MIM:610183; AllianceGenome:HGNC:30164
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Homo sapiens
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as: AWP1; ZA20D3; ZFAND5B
Summary: Predicted to enable polyubiquitin modification-dependent protein binding activity. Involved in cellular response to tumor necrosis factor; negative regulation of apoptotic process; and regulation of canonical NF-kappaB signal transduction. Predicted to be located in cytosol. [provided by Alliance of Genome Resources, Nov 2024]
Expression: Ubiquitous expression in testis (RPKM 50.8), thyroid (RPKM 41.4) and 25 other tissues See more
Orthologs: mouse all
NEW: Try the new Gene table
Try the new Transcript table

Genomic context

Location:: 15q25.1

Exon count:: 15

Annotation release	Status	Assembly	Chr	Location
RS_2024_08	current	GRCh38.p14 (GCF_000001405.40)	15	NC_000015.10 (80058951..80138393)
RS_2024_08	current	T2T-CHM13v2.0 (GCF_009914755.1)	15	NC_060939.1 (77923092..78001808)
RS_2024_09	previous assembly	GRCh37.p13 (GCF_000001405.25)	15	NC_000015.9 (80352018..80430735)

Chromosome 15 - NC_000015.10 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

Go to the top of the page Help

Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

Go to the top of the page Help

See details

Project title: HPA RNA-seq normal tissues HPA RNA-seq normal tissues
Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
BioProject: PRJEB4337
Publication: PMID 24309898
Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

Go to the top of the page Help

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Genetic associations of TMEM154, PRC1 and ZFAND6 loci with type 2 diabetes in an endogamous business community of North India.
Title: Genetic associations of TMEM154, PRC1 and ZFAND6 loci with type 2 diabetes in an endogamous business community of North India.
EIF4A3-induced circZFAND6 promotes breast cancer proliferation and metastasis through the miR-647/FASN axis.
Title: EIF4A3-induced circZFAND6 promotes breast cancer proliferation and metastasis through the miR-647/FASN axis.
Genetic Variants of HNF4A, WFS1, DUSP9, FTO, and ZFAND6 Genes Are Associated with Prediabetes Susceptibility and Inflammatory Markers in the Saudi Arabian Population.
Title: Genetic Variants of HNF4A, WFS1, DUSP9, FTO, and ZFAND6 Genes Are Associated with Prediabetes Susceptibility and Inflammatory Markers in the Saudi Arabian Population.
ZFAND6 was identified as a type 2 diabetes susceptibility gene. ZFAND6 plays a role in insulin secretion in vitro.
Title: Expression and functional assessment of candidate type 2 diabetes susceptibility genes identify four new genes contributing to human insulin secretion.
By observing the data obtained from the isothermal titration calorimetry assay, both of the human proteins (KRCC1 and ZFAND6) were demonstrated to bind to their respective Toxoplasma gondii SAG1 and SAG2 proteins.
Title: Measurement of binding strength between prey proteins interacting with Toxoplasma gondii SAG1 and SAG2 using isothermal titration calorimetry (ITC).
The AN1 domain of AWP1 mediated the functional interaction with tumor necrosis factor receptor-associated factor 2, and the A20 domain was responsible for the negative regulation of nuclear factor kappaB activation.
Title: AWP1 binds to tumor necrosis factor receptor-associated factor 2 (TRAF2) and is involved in TRAF2-mediated nuclear factor-kappaB signaling.
Observational study of gene-disease association, gene-gene interaction, and gene-environment interaction. (HuGE Navigator)
Title: Genetic risk reclassification for type 2 diabetes by age below or above 50 years using 40 type 2 diabetes risk single nucleotide polymorphisms.
Observational study and genome-wide association study of gene-disease association. (HuGE Navigator)
Title: Genome-wide searching of rare genetic variants in WTCCC data.
Clinical trial of gene-disease association and gene-environment interaction. (HuGE Navigator)
Title: Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score.

Submit: New GeneRIF Correction

Phenotypes

Go to the top of the page Help

Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

EBI GWAS Catalog

Description
Twelve type 2 diabetes susceptibility loci identified through large-scale association analysis. EBI GWAS Catalog EBI GWAS CatalogPubMed

Variation

Go to the top of the page Help

See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Interactions

Go to the top of the page Help

Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

Go to the top of the page Help

Markers

D15S969 (e-PCR)
- UniSTS:67680

RH94373 (e-PCR)
- UniSTS:92596

WI-11220 (e-PCR)
- UniSTS:27640

WI-15537 (e-PCR)
- UniSTS:33790

Gene Ontology Provided by GOA

Function	Evidence Code	Pubs
enables DNA binding	IEA Inferred from Electronic Annotation more info
enables molecular_function	ND No biological Data available more info
enables polyubiquitin modification-dependent protein binding	IBA Inferred from Biological aspect of Ancestor more info
enables polyubiquitin modification-dependent protein binding	ISS Inferred from Sequence or Structural Similarity more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables zinc ion binding	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in apoptotic process	IEA Inferred from Electronic Annotation more info
involved_in cellular response to tumor necrosis factor	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of apoptotic process	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in protein targeting to peroxisome	IBA Inferred from Biological aspect of Ancestor more info
involved_in protein targeting to peroxisome	ISS Inferred from Sequence or Structural Similarity more info
involved_in protein transport	IEA Inferred from Electronic Annotation more info
involved_in regulation of canonical NF-kappaB signal transduction	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
is_active_in cellular_component	ND No biological Data available more info
located_in cytosol	TAS Traceable Author Statement more info

General protein information

Go to the top of the page Help

Preferred Names: AN1-type zinc finger protein 6

Names: protein associated with PRK1; zinc finger, A20 domain containing 3; zinc finger, AN1-type domain 6

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001242911.2 → NP_001229840.1 AN1-type zinc finger protein 6 isoform a

See identical proteins and their annotated locations for NP_001229840.1

Status: VALIDATED

Description

Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Variants 1-7 all encode isoform a.

Source sequence(s)

AC092701, AL136598, AW571396, DB050060

Consensus CDS

CCDS10313.1

UniProtKB/Swiss-Prot

D3DW92, D3DW94, O95792, Q6FIF0, Q9BQF7, Q9GZY3

UniProtKB/TrEMBL

B2R6N3

Related

ENSP00000454137.1, ENST00000558494.5

Conserved Domains (2) summary

smart00154
Location:149 → 186

ZnF_AN1; AN1-like Zinc finger

pfam01754
Location:12 → 34

zf-A20; A20-like zinc finger
NM_001242912.2 → NP_001229841.1 AN1-type zinc finger protein 6 isoform a

See identical proteins and their annotated locations for NP_001229841.1

Status: VALIDATED

Description

Transcript Variant: This variant (3) differs in the 5' UTR compared to variant 1. Variants 1-7 all encode isoform a.

Source sequence(s)

AC092701, AW571396, BX363429, DB050060

Consensus CDS

CCDS10313.1

UniProtKB/Swiss-Prot

D3DW92, D3DW94, O95792, Q6FIF0, Q9BQF7, Q9GZY3

UniProtKB/TrEMBL

B2R6N3

Related

ENSP00000479071.1, ENST00000613266.4

Conserved Domains (2) summary

smart00154
Location:149 → 186

ZnF_AN1; AN1-like Zinc finger

pfam01754
Location:12 → 34

zf-A20; A20-like zinc finger
NM_001242913.2 → NP_001229842.1 AN1-type zinc finger protein 6 isoform a

See identical proteins and their annotated locations for NP_001229842.1

Status: VALIDATED

Description

Transcript Variant: This variant (4) differs in the 5' UTR compared to variant 1. Variants 1-7 all encode isoform a.

Source sequence(s)

AC092701, AW571396, CN428457

Consensus CDS

CCDS10313.1

UniProtKB/Swiss-Prot

D3DW92, D3DW94, O95792, Q6FIF0, Q9BQF7, Q9GZY3

UniProtKB/TrEMBL

B2R6N3

Related

ENSP00000478129.1, ENST00000616533.4

Conserved Domains (2) summary

smart00154
Location:149 → 186

ZnF_AN1; AN1-like Zinc finger

pfam01754
Location:12 → 34

zf-A20; A20-like zinc finger
NM_001242914.2 → NP_001229843.1 AN1-type zinc finger protein 6 isoform a

See identical proteins and their annotated locations for NP_001229843.1

Status: VALIDATED

Description

Transcript Variant: This variant (5) differs in the 5' UTR compared to variant 1. Variants 1-7 all encode isoform a.

Source sequence(s)

AC092701, AW571396, BG720174, BI562073

Consensus CDS

CCDS10313.1

UniProtKB/Swiss-Prot

D3DW92, D3DW94, O95792, Q6FIF0, Q9BQF7, Q9GZY3

UniProtKB/TrEMBL

B2R6N3

Related

ENSP00000484971.1, ENST00000618205.4

Conserved Domains (2) summary

smart00154
Location:149 → 186

ZnF_AN1; AN1-like Zinc finger

pfam01754
Location:12 → 34

zf-A20; A20-like zinc finger
NM_001242915.2 → NP_001229844.1 AN1-type zinc finger protein 6 isoform a

See identical proteins and their annotated locations for NP_001229844.1

Status: VALIDATED

Description

Transcript Variant: This variant (6) differs in the 5' UTR compared to variant 1. Variants 1-7 all encode isoform a.

Source sequence(s)

AF261138, AW571396, DA091136

Consensus CDS

CCDS10313.1

UniProtKB/Swiss-Prot

D3DW92, D3DW94, O95792, Q6FIF0, Q9BQF7, Q9GZY3

UniProtKB/TrEMBL

B2R6N3

Related

ENSP00000453291.1, ENST00000559835.5

Conserved Domains (2) summary

smart00154
Location:149 → 186

ZnF_AN1; AN1-like Zinc finger

pfam01754
Location:12 → 34

zf-A20; A20-like zinc finger
NM_001242916.2 → NP_001229845.1 AN1-type zinc finger protein 6 isoform a

See identical proteins and their annotated locations for NP_001229845.1

Status: VALIDATED

Description

Transcript Variant: This variant (7) differs in the 5' UTR compared to variant 1. Variants 1-7 all encode isoform a.

Source sequence(s)

AC092701, AW571396, DA091136, DR762914

Consensus CDS

CCDS10313.1

UniProtKB/Swiss-Prot

D3DW92, D3DW94, O95792, Q6FIF0, Q9BQF7, Q9GZY3

UniProtKB/TrEMBL

B2R6N3

Related

ENSP00000453709.1, ENST00000559775.5

Conserved Domains (2) summary

smart00154
Location:149 → 186

ZnF_AN1; AN1-like Zinc finger

pfam01754
Location:12 → 34

zf-A20; A20-like zinc finger
NM_001242917.2 → NP_001229846.1 AN1-type zinc finger protein 6 isoform b

See identical proteins and their annotated locations for NP_001229846.1

Status: VALIDATED

Description

Transcript Variant: This variant (8) differs in the 5' UTR and uses an alternate in-frame splice site in the 5' coding region, compared to variant 1. The encoded isoform (b) is shorter than isoform a.

Source sequence(s)

AC092701, AF061739, AW571396, DB050060

Consensus CDS

CCDS58395.1

UniProtKB/TrEMBL

B2R6N3

Related

ENSP00000454152.1, ENST00000559157.6

Conserved Domains (3) summary

smart00154
Location:137 → 174

ZnF_AN1; AN1-like Zinc finger

pfam01754
Location:12 → 35

zf-A20; A20-like zinc finger

pfam06484
Location:25 → 130

Ten_N; Teneurin Intracellular Region
NM_001242918.2 → NP_001229847.1 AN1-type zinc finger protein 6 isoform c

Status: VALIDATED

Description

Transcript Variant: This variant (9) differs in the 5' UTR and lacks an alternate in-frame exon in the 3' coding region, compared to variant 1. The encoded isoform (c) is shorter than isoform a.

Source sequence(s)

AC092701, AW571396, BP231220, DB050060

UniProtKB/TrEMBL

H3BM82

Related

ENSP00000454273.1, ENST00000564367.5

Conserved Domains (3) summary

pfam01754
Location:12 → 35

zf-A20; A20-like zinc finger

pfam06484
Location:25 → 117

Ten_N; Teneurin Intracellular Region

cl01438
Location:118 → 148

zf-AN1; AN1-like Zinc finger
NM_001242919.1 → NP_001229848.1 AN1-type zinc finger protein 6 isoform d

Status: VALIDATED

Description

Transcript Variant: This variant (10) differs in the 5' UTR and uses two alternate in-frame splice sites in the central coding region, compared to variant 1. The encoded isoform (d) is shorter than isoform a.

Source sequence(s)

AC092701, AW571396, BP234517

UniProtKB/TrEMBL

B2R6N3

Conserved Domains (2) summary

smart00154
Location:122 → 159

ZnF_AN1; AN1-like Zinc finger

pfam01754
Location:12 → 35

zf-A20; A20-like zinc finger
NM_019006.4 → NP_061879.2 AN1-type zinc finger protein 6 isoform a

See identical proteins and their annotated locations for NP_061879.2

Status: VALIDATED

Description

Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (a). Variants 1-7 all encode isoform a.

Source sequence(s)

AW571396, BC005283, DB050060

Consensus CDS

CCDS10313.1

UniProtKB/Swiss-Prot

D3DW92, D3DW94, O95792, Q6FIF0, Q9BQF7, Q9GZY3

UniProtKB/TrEMBL

B2R6N3

Related

ENSP00000261749.6, ENST00000261749.11

Conserved Domains (2) summary

smart00154
Location:149 → 186

ZnF_AN1; AN1-like Zinc finger

pfam01754
Location:12 → 34

zf-A20; A20-like zinc finger

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

NC_000015.10 Reference GRCh38.p14 Primary Assembly

Range

80058951..80138393

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_047432697.1 → XP_047288653.1 AN1-type zinc finger protein 6 isoform X1

UniProtKB/Swiss-Prot

D3DW92, D3DW94, O95792, Q6FIF0, Q9BQF7, Q9GZY3
XM_024449959.2 → XP_024305727.1 AN1-type zinc finger protein 6 isoform X1

UniProtKB/Swiss-Prot

D3DW92, D3DW94, O95792, Q6FIF0, Q9BQF7, Q9GZY3

UniProtKB/TrEMBL

B2R6N3

Conserved Domains (2) summary

smart00154
Location:149 → 186

ZnF_AN1; AN1-like Zinc finger

pfam01754
Location:12 → 34

zf-A20; A20-like zinc finger
XM_024449956.2 → XP_024305724.1 AN1-type zinc finger protein 6 isoform X1

UniProtKB/Swiss-Prot

D3DW92, D3DW94, O95792, Q6FIF0, Q9BQF7, Q9GZY3

UniProtKB/TrEMBL

B2R6N3

Conserved Domains (2) summary

smart00154
Location:149 → 186

ZnF_AN1; AN1-like Zinc finger

pfam01754
Location:12 → 34

zf-A20; A20-like zinc finger
XM_024449963.2 → XP_024305731.1 AN1-type zinc finger protein 6 isoform X1

UniProtKB/Swiss-Prot

D3DW92, D3DW94, O95792, Q6FIF0, Q9BQF7, Q9GZY3

UniProtKB/TrEMBL

B2R6N3

Conserved Domains (2) summary

smart00154
Location:149 → 186

ZnF_AN1; AN1-like Zinc finger

pfam01754
Location:12 → 34

zf-A20; A20-like zinc finger
XM_047432696.1 → XP_047288652.1 AN1-type zinc finger protein 6 isoform X1

UniProtKB/Swiss-Prot

D3DW92, D3DW94, O95792, Q6FIF0, Q9BQF7, Q9GZY3
XM_047432695.1 → XP_047288651.1 AN1-type zinc finger protein 6 isoform X1

UniProtKB/Swiss-Prot

D3DW92, D3DW94, O95792, Q6FIF0, Q9BQF7, Q9GZY3
XM_011521684.3 → XP_011519986.1 AN1-type zinc finger protein 6 isoform X1

See identical proteins and their annotated locations for XP_011519986.1

UniProtKB/Swiss-Prot

D3DW92, D3DW94, O95792, Q6FIF0, Q9BQF7, Q9GZY3

UniProtKB/TrEMBL

B2R6N3

Conserved Domains (2) summary

smart00154
Location:149 → 186

ZnF_AN1; AN1-like Zinc finger

pfam01754
Location:12 → 34

zf-A20; A20-like zinc finger
XM_047432694.1 → XP_047288650.1 AN1-type zinc finger protein 6 isoform X1

UniProtKB/Swiss-Prot

D3DW92, D3DW94, O95792, Q6FIF0, Q9BQF7, Q9GZY3