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    Smap2 small ArfGAP2 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 298500, updated on 2-Nov-2024

    Summary

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    Official Symbol
    Smap2provided by RGD
    Official Full Name
    small ArfGAP2provided by RGD
    Primary source
    RGD:1308418
    See related
    EnsemblRapid:ENSRNOG00000011421 AllianceGenome:RGD:1308418
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    Smap1l; RGD1308418
    Summary
    Predicted to enable GTPase activator activity. Predicted to be located in cytosol and nucleoplasm. Predicted to be active in cytoplasm. Orthologous to human SMAP2 (small ArfGAP2). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Biased expression in Spleen (RPKM 291.9), Brain (RPKM 226.4) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Smap2 in Genome Data Viewer
    Location:
    5q36
    Exon count:
    10
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 5 NC_086023.1 (139815737..139862156, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 5 NC_051340.1 (134530542..134576938, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 5 NC_005104.4 (139885321..139931366, complement)

    Chromosome 5 - NC_086023.1Genomic Context describing neighboring genes Neighboring gene exonuclease 5 Neighboring gene zinc finger protein 69 Neighboring gene ribosomal protein L10A like 3 Neighboring gene collagen type IX alpha 2 chain Neighboring gene uncharacterized LOC108351024

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article
    2. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables GTPase activator activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytosol IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    stromal membrane-associated protein 2
    Names
    stromal membrane-associated GTPase-activating protein 2

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001100669.1 → NP_001094139.1  stromal membrane-associated protein 2

      See identical proteins and their annotated locations for NP_001094139.1

      Status: VALIDATED

      Source sequence(s)
      BC099210, BC161927, CB702191
      UniProtKB/TrEMBL
      A6IS02, B1WBX6, F1LMJ5
      Related
      ENSRNOP00000015250.7, ENSRNOT00000015250.9
      Conserved Domains (2) summary
      COG5180
      Location:102 → 419
      PBP1; PAB1-binding protein PBP1, interacts with poly(A)-binding protein [RNA processing and modification]
      cd08859
      Location:16 → 122
      ArfGap_SMAP2; Stromal membrane-associated protein 2; a subfamily of the ArfGAP family

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086023.1 Reference GRCr8

      Range
      139815737..139862156 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_063287432.1 → XP_063143502.1  stromal membrane-associated protein 2 isoform X1

      UniProtKB/TrEMBL
      B1WBX6, F1LMJ5
    Nucleotide Protein Strain
    Heading Accession and Version

    Gene LinkOut

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