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    SHR5 Shr5p [ Saccharomyces cerevisiae S288C ]

    Gene ID: 854039, updated on 18-Sep-2024

    Summary

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    Official Symbol
    SHR5
    Official Full Name
    Shr5p
    Primary source
    SGD:S000005470
    Locus tag
    YOL110W
    See related
    AllianceGenome:SGD:S000005470; FungiDB:YOL110W; VEuPathDB:YOL110W
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Also known as
    ERF4
    Summary
    Contributes to palmitoyltransferase activity. Involved in protein palmitoylation and protein targeting to membrane. Is extrinsic component of endoplasmic reticulum membrane. Part of endoplasmic reticulum palmitoyltransferase complex. [provided by Alliance of Genome Resources, Apr 2022]
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    Genomic context

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    See SHR5 in Genome Data Viewer
    Location:
    chromosome: XV
    Exon count:
    1
    Sequence:
    Chromosome: XV; NC_001147.6 (109176..109889)

    Chromosome XV - NC_001147.6Genomic Context describing neighboring genes Neighboring gene Rab GTPase-activating protein MSB4 Neighboring gene Mdy2p Neighboring gene Zeo1p Neighboring gene tRNA-Gly

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001147.6

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. A fluorescence-based assay to monitor autopalmitoylation of zDHHC proteins applicable to high-throughput screening. Hamel LD, et al. Anal Biochem, 2014 Sep 1. PMID 24878334, Free PMC Article
    2. Mutational analysis of Saccharomyces cerevisiae Erf2 reveals a two-step reaction mechanism for protein palmitoylation by DHHC enzymes. Mitchell DA, et al. J Biol Chem, 2010 Dec 3. PMID 20851885, Free PMC Article
    3. Identification of a Ras palmitoyltransferase in Saccharomyces cerevisiae. Lobo S, et al. J Biol Chem, 2002 Oct 25. PMID 12193598
    4. Mutations in the SHR5 gene of Saccharomyces cerevisiae suppress Ras function and block membrane attachment and palmitoylation of Ras proteins. Jung V, et al. Mol Cell Biol, 1995 Mar. PMID 7532279, Free PMC Article
    5. Erf4p and Erf2p form an endoplasmic reticulum-associated complex involved in the plasma membrane localization of yeast Ras proteins. Zhao L, et al. J Biol Chem, 2002 Dec 20. PMID 12379641

    See all (30) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Erf4 is required for the stable formation of the palmitoyl-Erf2 intermediate, the first step of palmitoyl transfer to protein substrates.
      Title: The Erf4 subunit of the yeast Ras palmitoyl acyltransferase is required for stability of the Acyl-Erf2 intermediate and palmitoyl transfer to a Ras2 substrate.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    contributes_to palmitoyltransferase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in protein palmitoylation IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in protein palmitoylation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in protein targeting to membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in protein targeting to membrane IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in endoplasmic reticulum HDA PubMed 
    located_in endoplasmic reticulum IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in endoplasmic reticulum membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    part_of endoplasmic reticulum palmitoyltransferase complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of endoplasmic reticulum palmitoyltransferase complex IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    Shr5p
    NP_014531.1
    • Palmitoyltransferase subunit; this complex adds a palmitoyl lipid moiety to heterolipidated substrates such as Ras1p and Ras2p through a thioester linkage; palmitoylation is required for Ras2p membrane localization; Palmitoyltransferase is composed of Shr5p and Erf2

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001147.6 Reference assembly

      Range
      109176..109889
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001183364.1 → NP_014531.1  TPA: Shr5p [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_014531.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D6W1V7, P41912
      UniProtKB/TrEMBL
      A6ZNA0, B3LIV5, C7GSS6, C8ZHK5, G2WMC6, N1NXL2
      Conserved Domains (1) summary
      pfam10256
      Location:116 → 230
      Erf4; Golgin subfamily A member 7/ERF4 family
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P41912.1

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