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    Cd276 Cd276 molecule [ Rattus norvegicus (Norway rat) ]

    Gene ID: 315716, updated on 9-Jul-2024

    Summary

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    Official Symbol
    Cd276provided by RGD
    Official Full Name
    Cd276 moleculeprovided by RGD
    Primary source
    RGD:727815
    See related
    AllianceGenome:RGD:727815
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    B7h3; B7RP-2
    Summary
    Predicted to enable identical protein binding activity and signaling receptor binding activity. Predicted to be involved in T cell activation; T cell receptor signaling pathway; and positive regulation of interferon-gamma production. Predicted to act upstream of or within several processes, including positive regulation of osteoblast differentiation; regulation of T cell proliferation; and regulation of cytokine production. Predicted to be integral component of membrane. Predicted to be active in external side of plasma membrane. Orthologous to human CD276 (CD276 molecule). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Biased expression in Adrenal (RPKM 72.9), Heart (RPKM 69.2) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Cd276 in Genome Data Viewer
    Location:
    8q24
    Exon count:
    8
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 8 NC_086026.1 (67833587..67863918, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 8 NC_051343.1 (58937751..58968082, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 8 NC_005107.4 (63312060..63350411, complement)

    Chromosome 8 - NC_086026.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC100911193 Neighboring gene inhibitory synaptic factor 1 Neighboring gene neuroplastin Neighboring gene nucleophosmin-like Neighboring gene REC114 meiotic recombination protein

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Structure and T cell inhibition properties of B7 family member, B7-H3. Vigdorovich V, et al. Structure, 2013 May 7. PMID 23583036, Free PMC Article
    2. The immune regulatory protein B7-H3 promotes osteoblast differentiation and bone mineralization. Suh WK, et al. Proc Natl Acad Sci U S A, 2004 Aug 31. PMID 15317945, Free PMC Article
    3. B7-H3: a costimulatory molecule for T cell activation and IFN-gamma production. Chapoval AI, et al. Nat Immunol, 2001 Mar. PMID 11224528
    4. Characterization of mouse and human B7-H3 genes. Sun M, et al. J Immunol, 2002 Jun 15. PMID 12055244
    5. The B7 family member B7-H3 preferentially down-regulates T helper type 1-mediated immune responses. Suh WK, et al. Nat Immunol, 2003 Sep. PMID 12925852

    See all (11) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables identical protein binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables signaling receptor binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables signaling receptor binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in T cell activation IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in T cell activation ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of T cell proliferation ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in T cell receptor signaling pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within negative regulation of T cell proliferation ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within negative regulation of inflammatory response ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within negative regulation of interleukin-2 production ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within negative regulation of type II interferon production ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of T cell proliferation IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within positive regulation of T cell proliferation ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of T cell proliferation ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within positive regulation of bone mineralization ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within positive regulation of interleukin-2 production ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within positive regulation of osteoblast differentiation ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of type II interferon production IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in positive regulation of type II interferon production ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in regulation of cytokine production IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within regulation of immune response ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    is_active_in external side of plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in external side of plasma membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    CD276 antigen
    Names
    B7 homolog 3
    B7-H3
    costimulatory molecule

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_182824.2 → NP_877976.1  CD276 antigen precursor

      See identical proteins and their annotated locations for NP_877976.1

      Status: PROVISIONAL

      Source sequence(s)
      BC100064
      UniProtKB/Swiss-Prot
      Q7TPB4
      UniProtKB/TrEMBL
      A0A8L2QPH5
      Related
      ENSRNOP00000049249.5, ENSRNOT00000042681.6
      Conserved Domains (3) summary
      smart00410
      Location:37 → 138
      IG_like; Immunoglobulin like
      pfam00047
      Location:151 → 231
      ig; Immunoglobulin domain
      cl11960
      Location:44 → 139
      Ig; Immunoglobulin domain

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086026.1 Reference GRCr8

      Range
      67833587..67863918 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q7TPB4.1 GenPept UniProtKB/Swiss-Prot:Q7TPB4

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Chemical Information
    Molecular Biology Databases
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