NCE102 Nce102p [Saccharomyces cerevisiae S288C] - Gene

Summary

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Gene symbol: NCE102
Gene description: Nce102p
Primary source: FungiDB:YPR149W
Locus tag: YPR149W
See related: SGD:S000006353; AllianceGenome:SGD:S000006353; VEuPathDB:YPR149W
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Saccharomyces cerevisiae S288C (strain: S288C)
Lineage: Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Also known as: NCE2
Summary: Involved in several processes, including eisosome assembly; regulation of fungal-type cell wall organization; and regulation of phospholipid translocation. Acts upstream of or within vacuole fusion. Located in cellular bud membrane and mating projection membrane. Colocalizes with eisosome. [provided by Alliance of Genome Resources, Apr 2022]
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Genomic context

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See NCE102 in Genome Data Viewer

Location:: chromosome: XVI

Exon count:: 1

Sequence:: Chromosome: XVI; NC_001148.4 (829918..830439)

Chromosome XVI - NC_001148.4 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_001148.4

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Microdomain Protein Nce102 Is a Local Sensor of Plasma Membrane Sphingolipid Balance.
Title: Microdomain Protein Nce102 Is a Local Sensor of Plasma Membrane Sphingolipid Balance.
Plasma Membrane Protein Nce102 Modulates Morphology and Function of the Yeast Vacuole.
Title: Plasma Membrane Protein Nce102 Modulates Morphology and Function of the Yeast Vacuole.
Attenuation of the endocytic pathway through deletion of the gene END3 impaired the Nce102-mediated rescue, suggesting that the Nce102 mutants lead to suppression through the yeast endocytic pathway.
Title: The Plasma Membrane Protein Nce102 Implicated in Eisosome Formation Rescues a Heme Defect in Mitochondria.
Data indicate that mutant nce102 sng1 cells show features of impaired Pkh/Ypk signalling, including increased reactive oxygen species accumulation.
Title: Sng1 associates with Nce102 to regulate the yeast Pkh-Ypk signalling module in response to sphingolipid status.
Results suggest that Nce102 might act as a sensor of sphingolipids that regulates plasma membrane function.
Title: A genome-wide screen for genes affecting eisosomes reveals Nce102 function in sphingolipid signaling.
Overexpression of NCE102 in wild type yeast strain BY4742 neither protected against oxidative stress due to diethylmaleate nor extended yeast lifespan compared to its parental wild type strain.
Title: Nonclassical export pathway: overexpression of NCE102 reduces protein and DNA damage and prolongs lifespan in an SGS1 deficient Saccharomyces cerevisiae.

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Homology

Orthologs from OrthoDB

Gene Ontology Provided by SGD

Function	Evidence Code	Pubs
enables molecular_function	ND No biological Data available more info

Process	Evidence Code	Pubs
involved_in eisosome assembly	IBA Inferred from Biological aspect of Ancestor more info
involved_in eisosome assembly	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of protein phosphorylation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in plasma membrane organization	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in protein localization to plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
involved_in protein localization to plasma membrane	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in protein secretion	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in protein transport	IEA Inferred from Electronic Annotation more info
involved_in regulation of fungal-type cell wall organization	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of phospholipid translocation	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within vacuole fusion	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
located_in cell periphery	HDA more info	PubMed
located_in cellular bud membrane	IDA Inferred from Direct Assay more info	PubMed
located_in cytoplasm	HDA more info	PubMed
located_in endoplasmic reticulum	HDA more info	PubMed
located_in mating projection membrane	IDA Inferred from Direct Assay more info	PubMed
located_in membrane	IEA Inferred from Electronic Annotation more info
located_in membrane	ISM Inferred from Sequence Model more info	PubMed
located_in mitochondrion	HDA more info	PubMed
located_in plasma membrane	HDA more info	PubMed
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in plasma membrane	IDA Inferred from Direct Assay more info	PubMed
located_in plasma membrane	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: Nce102p

NP_015475.1

Protein involved in regulation of pheromone response and mating; contains transmembrane domains; involved in secretion of proteins that lack classical secretory signal sequences; component of the detergent-insoluble glycolipid-enriched complexes (DIGs); NCE102 has a paralog, FHN1, that arose from the whole genome duplication