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    Ube2g2 ubiquitin-conjugating enzyme E2G 2 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 294331, updated on 2-Nov-2024

    Summary

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    Official Symbol
    Ube2g2provided by RGD
    Official Full Name
    ubiquitin-conjugating enzyme E2G 2provided by RGD
    Primary source
    RGD:1304860
    See related
    EnsemblRapid:ENSRNOG00000001222 AllianceGenome:RGD:1304860
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Predicted to enable identical protein binding activity and ubiquitin conjugating enzyme activity. Predicted to be involved in several processes, including cellular response to interferon-beta; negative regulation of retrograde protein transport, ER to cytosol; and protein K48-linked ubiquitination. Predicted to be located in lipid droplet. Predicted to be active in cytosol and endoplasmic reticulum. Orthologous to human UBE2G2 (ubiquitin conjugating enzyme E2 G2). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Biased expression in Muscle (RPKM 196.9), Heart (RPKM 132.7) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Ube2g2 in Genome Data Viewer
    Location:
    20p12
    Exon count:
    7
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 20 NC_086038.1 (10983322..11005060, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 20 NC_051355.1 (10983734..11005468, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 20 NC_005119.4 (11700089..11721823, complement)

    Chromosome 20 - NC_086038.1Genomic Context describing neighboring genes Neighboring gene thrombospondin-type laminin G domain and EAR repeats Neighboring gene 28S ribosomal protein S36, mitochondrial-like Neighboring gene keratin associated protein 10-9 Neighboring gene small nuclear ribonucleoprotein polypeptide G, pseudogene 3 Neighboring gene small ubiquitin-like modifier 3 Neighboring gene PTTG1 interacting protein

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Dimeric Ube2g2 simultaneously engages donor and acceptor ubiquitins to form Lys48-linked ubiquitin chains. Liu W, et al. EMBO J, 2014 Jan 7. PMID 24366945, Free PMC Article
    2. Mechanistic insights into active site-associated polyubiquitination by the ubiquitin-conjugating enzyme Ube2g2. Li W, et al. Proc Natl Acad Sci U S A, 2009 Mar 10. PMID 19223579, Free PMC Article
    3. A ubiquitin ligase transfers preformed polyubiquitin chains from a conjugating enzyme to a substrate. Li W, et al. Nature, 2007 Mar 15. PMID 17310145
    4. Endoplasmic reticulum (ER)-associated degradation of T cell receptor subunits. Involvement of ER-associated ubiquitin-conjugating enzymes (E2s). Tiwari S, et al. J Biol Chem, 2001 May 11. PMID 11278356
    5. CYP3A4 ubiquitination by gp78 (the tumor autocrine motility factor receptor, AMFR) and CHIP E3 ligases. Pabarcus MK, et al. Arch Biochem Biophys, 2009 Mar 1. PMID 19103148, Free PMC Article

    See all (13) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables identical protein binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables ubiquitin conjugating enzyme activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables ubiquitin-protein transferase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in ERAD pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within ERAD pathway ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in ERAD pathway ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in cellular response to interferon-beta ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in negative regulation of retrograde protein transport, ER to cytosol ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in protein K48-linked ubiquitination ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cytosol IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in endoplasmic reticulum IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in endoplasmic reticulum ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in lipid droplet ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    ubiquitin-conjugating enzyme E2 G2
    Names
    ubiquitin-conjugating enzyme E2G 2 (UBC7 homolog, yeast)
    NP_001099850.1
    XP_063135125.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001106380.2 → NP_001099850.1  ubiquitin-conjugating enzyme E2 G2

      See identical proteins and their annotated locations for NP_001099850.1

      Status: PROVISIONAL

      Source sequence(s)
      JAXUCZ010000020
      UniProtKB/TrEMBL
      A0A8I6GKI1, A0A8J8Y678, B2RYD0, F1MAH9
      Conserved Domains (1) summary
      COG5078
      Location:1 → 163
      COG5078; Ubiquitin-protein ligase [Posttranslational modification, protein turnover, chaperones]

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086038.1 Reference GRCr8

      Range
      10983322..11005060 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_063279055.1 → XP_063135125.1  ubiquitin-conjugating enzyme E2 G2 isoform X1

      UniProtKB/TrEMBL
      A6JK78
      Related
      ENSRNOP00000001636.7, ENSRNOT00000001636.9
    Nucleotide Protein Strain
    Heading Accession and Version

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