Larp6 La ribonucleoprotein 6, translational regulator [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Larp6provided by RGD
Official Full Name: La ribonucleoprotein 6, translational regulatorprovided by RGD
Primary source: RGD:1308414
See related: EnsemblRapid:ENSRNOG00000012438 AllianceGenome:RGD:1308414
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: RGD1308414
Summary: Predicted to enable RNA binding activity and myosin binding activity. Predicted to be involved in positive regulation of collagen biosynthetic process; positive regulation of mRNA binding activity; and positive regulation of translation. Predicted to be part of polysome. Predicted to be active in nucleus. Orthologous to human LARP6 (La ribonucleoprotein 6, translational regulator). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Biased expression in Brain (RPKM 115.4), Heart (RPKM 24.6) and 7 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 8q24

Exon count:: 3

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	8	NC_086026.1 (70079753..70101175)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	8	NC_051343.1 (61183744..61205548)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	8	NC_005107.4 (65611570..65632706)

Chromosome 8 - NC_086026.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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General gene information

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Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables RNA stem-loop binding	ISO Inferred from Sequence Orthology more info
enables mRNA 5'-UTR binding	ISO Inferred from Sequence Orthology more info
enables mRNA binding	IBA Inferred from Biological aspect of Ancestor more info
enables myosin binding	ISO Inferred from Sequence Orthology more info
enables sequence-specific mRNA binding	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in RNA processing	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of collagen biosynthetic process	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
located_in cytoplasm	ISO Inferred from Sequence Orthology more info
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info
located_in nucleus	ISO Inferred from Sequence Orthology more info
part_of ribonucleoprotein complex	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: la-related protein 6

Names: La ribonucleoprotein domain family, member 6; death-associated LA motif protein

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001108154.1 → NP_001101624.1 la-related protein 6

See identical proteins and their annotated locations for NP_001101624.1

Status: PROVISIONAL

Source sequence(s)

CH473975

UniProtKB/TrEMBL

A6J549, D3ZCR5

Related

ENSRNOP00000017147.6, ENSRNOT00000017147.8

Conserved Domains (2) summary

cd08033
Location:93 → 169

LARP_6; La RNA-binding domain of La-related protein 6

cd12289
Location:184 → 292

RRM_LARP6; RNA recognition motif in La-related protein 6 (LARP6) and similar proteins