U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Links from GEO Profiles

    • Showing Current items.

    SLC22A17 solute carrier family 22 member 17 [ Homo sapiens (human) ]

    Gene ID: 51310, updated on 2-Nov-2024

    Summary

    Go to the top of the page Help
    Official Symbol
    SLC22A17provided by HGNC
    Official Full Name
    solute carrier family 22 member 17provided by HGNC
    Primary source
    HGNC:HGNC:23095
    See related
    Ensembl:ENSG00000092096 MIM:611461; AllianceGenome:HGNC:23095
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    BOCT; BOIT; 24p3R; NGALR; hBOIT; NGALR2; NGALR3
    Summary
    Predicted to enable transmembrane signaling receptor activity. Predicted to be involved in siderophore transport. Located in organelle membrane and plasma membrane. [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Biased expression in brain (RPKM 47.7), prostate (RPKM 11.1) and 10 other tissues See more
    Orthologs
    mouse all
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    Go to the top of the page Help
    See SLC22A17 in Genome Data Viewer
    Location:
    14q11.2
    Exon count:
    10
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 14 NC_000014.9 (23346311..23352887, complement)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 14 NC_060938.1 (17547327..17553903, complement)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 14 NC_000014.8 (23815520..23822096, complement)

    Chromosome 14 - NC_000014.9Genomic Context describing neighboring genes Neighboring gene BCL2L2-PABPN1 readthrough Neighboring gene H3K4me1 hESC enhancer GRCh37_chr14:23776901-23777734 Neighboring gene BCL2 like 2 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr14:23789757-23790407 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr14:23790419-23791230 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr14:23791231-23792040 Neighboring gene poly(A) binding protein nuclear 1 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 5608 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr14:23832478-23832978 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr14:23832979-23833479 Neighboring gene embryonal Fyn-associated substrate Neighboring gene interleukin 25

    Genomic regions, transcripts, and products

    Go to the top of the page Help

    Go to nucleotide: Graphics FASTA GenBank

    Expression

    Go to the top of the page Help
    • Project title: HPA RNA-seq normal tissues HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

    Go to the top of the pageHelp

    Related articles in PubMed

    1. The mRNA of solute carrier family 22, member 17 (SLC22A17) plays the potential diagnostic and prognostic role in advantage non-small cell lung cancer patients. Qin W, et al. Ann Biol Clin (Paris), 2024 Feb 24. PMID 38391165
    2. NGALR is overexpressed and regulated by hypomethylation in esophageal squamous cell carcinoma. Cui L, et al. Clin Cancer Res, 2008 Dec 1. PMID 19047093
    3. Lipocalin 2 decreases senescence of bone marrow-derived mesenchymal stem cells under sub-lethal doses of oxidative stress. Bahmani B, et al. Cell Stress Chaperones, 2014 Sep. PMID 24452457, Free PMC Article
    4. Increased expression of neutrophil gelatinase-associated lipocalin receptor by interleukin-1β in human mesangial cells via MAPK/ERK activation. Mao S, et al. Int J Mol Med, 2011 Apr. PMID 21305251
    5. Identification of immune cells and mRNA associated with prognosis of gastric cancer. Wang M, et al. BMC Cancer, 2020 Mar 12. PMID 32164594, Free PMC Article

    See all (23) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. SLC22A17 as a Cell Death-Linked Regulator of Tight Junctions in Cerebral Ischemia.
      Title: SLC22A17 as a Cell Death-Linked Regulator of Tight Junctions in Cerebral Ischemia.
    2. The mRNA of solute carrier family 22, member 17 (SLC22A17) plays the potential diagnostic and prognostic role in advantage non-small cell lung cancer patients.
      Title: The mRNA of solute carrier family 22, member 17 (SLC22A17) plays the potential diagnostic and prognostic role in advantage non-small cell lung cancer patients.
    3. Identification of immune cells and mRNA associated with prognosis of gastric cancer.
      Title: Identification of immune cells and mRNA associated with prognosis of gastric cancer.
    4. Results showed the expression levels of NGAL and NGALR significantly downregulated in clear cell renal cell carcinoma samples.
      Title: The expression analysis of NGAL and NGALR in clear cell renal cell carcinoma.
    5. Biochemical and Structural Characterization of the Interaction between the Siderocalin NGAL/LCN2 (Neutrophil Gelatinase-associated Lipocalin/Lipocalin 2) and the N-terminal Domain of Its Endocytic Receptor SLC22A17.
      Title: Biochemical and Structural Characterization of the Interaction between the Siderocalin NGAL/LCN2 (Neutrophil Gelatinase-associated Lipocalin/Lipocalin 2) and the N-terminal Domain of Its Endocytic Receptor SLC22A17.
    6. Two novel variants in SLC22A17 and SLC22A7 were significantly associated with anthracycline-induced cardiotoxicity.
      Title: Genetic variants in SLC22A17 and SLC22A7 are associated with anthracycline-induced cardiotoxicity in children.
    7. Lipocalin 2 might restore the health and regeneration potential of MSCs by decreasing senescence
      Title: Lipocalin 2 decreases senescence of bone marrow-derived mesenchymal stem cells under sub-lethal doses of oxidative stress.
    8. No significant difference was found in the expressions of NGALR mRNA in placenta among moderate preeclampsia group, severe preeclampsia group and control group.
      Title: [Correlation of lipocalin-2 and its receptor expressions with preeclampsia].
    9. NGAL and NGALR expression might be served as novel prognostic factors and potential therapeutic targets in Hepatocellular carcinoma.
      Title: NGAL and NGALR overexpression in human hepatocellular carcinoma toward a molecular prognostic classification.
    10. This study suggested that NGAL and NGALR expression are frequently up-regulated in gliomas, and are closely associated with poor clinical outcome.
      Title: NGAL and NGALR are frequently overexpressed in human gliomas and are associated with clinical prognosis.
    Submit: New GeneRIF Correction See all GeneRIFs (13)

    Phenotypes

    Go to the top of the page Help

    Find tests for this gene in the NIH Genetic Testing Registry (GTR)

    Review eQTL and phenotype association data in this region using PheGenI

    Variation

    Go to the top of the page Help

    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    Genotypes

    Pathways from PubChem

    Go to the top of the page

    Interactions

    Go to the top of the page Help
    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Go to the top of the page Help

    Markers

    Homology

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables transmembrane signaling receptor activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables transmembrane transporter activity TAS
    Traceable Author Statement
    more info
    		  
    Process Evidence Code Pubs
    involved_in intracellular iron ion homeostasis TAS
    Traceable Author Statement
    more info
    		  
    involved_in siderophore transport ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in transmembrane transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in organelle membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in plasma membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in plasma membrane TAS
    Traceable Author Statement
    more info
    		  
    located_in vacuolar membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

    Go to the top of the page Help
    Preferred Names
    solute carrier family 22 member 17
    Names
    24p3 receptor
    NGAL receptor
    brain-type organic cation transporter
    lipocalin-2 receptor
    neutrophil gelatinase-associated lipocalin receptor
    potent brain type organic ion transporter
    solute carrier family 22 (organic cation transporter), member 17

    NCBI Reference Sequences (RefSeq)

    Go to the top of the page Help

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001289050.1 → NP_001275979.1  solute carrier family 22 member 17 isoform c

      See identical proteins and their annotated locations for NP_001275979.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) uses an alternate splice junction at the 5' end of a coding exon and an alternate in-frame splice junction at the 3' end of another exon compared to variant 1. The resulting isoform (c) is shorter at the N-terminus and lacks an alternate internal segment compared to isoform a.
      Source sequence(s)
      AK308661, BC020565, BF345519, DQ658848
      UniProtKB/Swiss-Prot
      Q8WUG5
      Conserved Domains (1) summary
      cl28910
      Location:88 → 258
      MFS; Major Facilitator Superfamily

    2. NM_016609.7 → NP_057693.4  solute carrier family 22 member 17 isoform b

      Status: VALIDATED

      Source sequence(s)
      AL049829
      Consensus CDS
      CCDS9594.3
      Related
      ENSP00000346824.5, ENST00000354772.10
      Conserved Domains (1) summary
      cd17445
      Location:174 → 587
      MFS_SLC22A17; Solute carrier family 22, member 17 of the Major Facilitator Superfamily

    3. NM_020372.4 → NP_065105.3  solute carrier family 22 member 17 isoform a

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) encodes the longest isoform (a).
      Source sequence(s)
      AL049829
      Consensus CDS
      CCDS9593.2
      UniProtKB/Swiss-Prot
      A0A1C7CYV9, A4UA13, A8MUT0, Q2TAB0, Q5BKY8, Q86U04, Q8WUG5, Q9H1D3, Q9NQD5
      Related
      ENSP00000380437.2, ENST00000397267.6
      Conserved Domains (1) summary
      cd17445
      Location:174 → 605
      MFS_SLC22A17; Solute carrier family 22, member 17 of the Major Facilitator Superfamily

    RNA

    1. NR_110290.2 RNA Sequence

      Status: VALIDATED

      Description
      Transcript Variant: This variant (4) lacks two alternate internal exons and uses two alternate splice junctions compared to variant 1. This variant is represented as non-coding because the use of the 5'-most expected translational start codon, as used in variant 1, renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
      Source sequence(s)
      BC030559, BI758221
      Related
      ENST00000474057.6

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000014.9 Reference GRCh38.p14 Primary Assembly

      Range
      23346311..23352887 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060938.1 Alternate T2T-CHM13v2.0

      Range
      17547327..17553903 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q8WUG5.2 GenPept UniProtKB/Swiss-Prot:Q8WUG5

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Chemical Information
    Molecular Biology Databases
    Research Materials
    Tools
    Miscellaneous