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    HTR1F 5-hydroxytryptamine receptor 1F [ Homo sapiens (human) ]

    Gene ID: 3355, updated on 28-Oct-2024

    Summary

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    Official Symbol
    HTR1Fprovided by HGNC
    Official Full Name
    5-hydroxytryptamine receptor 1Fprovided by HGNC
    Primary source
    HGNC:HGNC:5292
    See related
    Ensembl:ENSG00000179097 MIM:182134; AllianceGenome:HGNC:5292
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    5HT6; MR77; 5-HT1F; HTR1EL; 5-HT-1F
    Summary
    Enables Gi/o-coupled serotonin receptor activity; serotonin binding activity; and serotonin receptor activity. Involved in adenylate cyclase-inhibiting serotonin receptor signaling pathway. Located in plasma membrane. [provided by Alliance of Genome Resources, Oct 2024]
    Expression
    Low expression observed in reference dataset See more
    Orthologs
    mouse all
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    Genomic context

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    See HTR1F in Genome Data Viewer
    Location:
    3p11.2-p11.1
    Exon count:
    6
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 3 NC_000003.12 (87792706..87993839)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 3 NC_060927.1 (87868616..88069681)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 3 NC_000003.11 (87841856..88042989)

    Chromosome 3 - NC_000003.12Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC105377198 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr3:87775589-87776580 Neighboring gene OCT4-NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr3:87776581-87777572 Neighboring gene RNA, U6 small nuclear 873, pseudogene Neighboring gene CRISPRi-validated cis-regulatory element chr3.2983 Neighboring gene CRISPRi-validated cis-regulatory element chr3.2985 Neighboring gene MED14-independent group 3 enhancer GRCh37_chr3:87963222-87964421 Neighboring gene RNA, U6atac small nuclear 6, pseudogene Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 14545 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 14546 Neighboring gene MED14-independent group 3 enhancer GRCh37_chr3:88094831-88096030 Neighboring gene uncharacterized LOC128031834 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 14547 Neighboring gene H3K27ac hESC enhancer GRCh37_chr3:88108555-88109114 Neighboring gene CGG triplet repeat binding protein 1 Neighboring gene zinc finger protein 654 Neighboring gene chromobox 5 pseudogene 1

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: HPA RNA-seq normal tissues HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

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    Related articles in PubMed

    1. Chromosomal localization of the 5-HT1F receptor gene: no evidence for involvement in response to sumatriptan in migraine patients. Maassen VanDenBrink A, et al. Am J Med Genet, 1998 Jun 5. PMID 9632173
    2. The 5-hydroxytryptamine receptor 1F stimulates mitochondrial biogenesis and angiogenesis in endothelial cells. Dupre TV, et al. Biochem Pharmacol, 2019 Nov. PMID 31542386, Free PMC Article
    3. Human Beta Cells Produce and Release Serotonin to Inhibit Glucagon Secretion from Alpha Cells. Almaça J, et al. Cell Rep, 2016 Dec 20. PMID 28009296, Free PMC Article
    4. Molecular cloning and functional expression of 5-HT1E-like rat and human 5-hydroxytryptamine receptor genes. Lovenberg TW, et al. Proc Natl Acad Sci U S A, 1993 Mar 15. PMID 8384716, Free PMC Article
    5. Inactive and active state structures template selective tools for the human 5-HT(5A) receptor. Zhang S, et al. Nat Struct Mol Biol, 2022 Jul. PMID 35835867, Free PMC Article

    See all (26) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. stimulation of 5-HT1F receptor is involved in mitochondrial biogenesis in endothelial cells.
      Title: The 5-hydroxytryptamine receptor 1F stimulates mitochondrial biogenesis and angiogenesis in endothelial cells.
    2. Supporting this model, pharmacological activation of 5-HT1F receptors reduces glucagon secretion and has hypoglycemic effects in diabetic mice. Thus, modulation of serotonin signaling in the islet represents a drug intervention opportunity
      Title: Human Beta Cells Produce and Release Serotonin to Inhibit Glucagon Secretion from Alpha Cells.
    3. 5-HT6 show no striking effects on executive function in the Chinese Han population.
      Title: Association analysis of TPH2, 5-HT2A, and 5-HT6 with executive function in a young Chinese Han population.
    4. Clinical trial of gene-disease association, gene-environment interaction, and pharmacogenomic / toxicogenomic. (HuGE Navigator)
      Title: Pharmacogenetics of antipsychotic response in the CATIE trial: a candidate gene analysis.
    5. Observational study of gene-disease association. (HuGE Navigator)
      Title: Association study of the serotoninergic system in migraine in the Spanish population.
    Submit: New GeneRIF Correction

    Phenotypes

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    Find tests for this gene in the NIH Genetic Testing Registry (GTR)

    Review eQTL and phenotype association data in this region using PheGenI

    Variation

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    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    Genotypes

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables G protein-coupled serotonin receptor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables G protein-coupled serotonin receptor activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables G protein-coupled serotonin receptor activity IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    enables Gi/o-coupled serotonin receptor activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables neurotransmitter receptor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables serotonin binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables serotonin receptor activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in adenylate cyclase-inhibiting serotonin receptor signaling pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in adenylate cyclase-inhibiting serotonin receptor signaling pathway IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in chemical synaptic transmission IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in dendrite IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in plasma membrane IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    located_in plasma membrane TAS
    Traceable Author Statement
    more info
    		  
    located_in synapse IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    5-hydroxytryptamine receptor 1F
    Names
    5-hydroxytryptamine (serotonin) receptor 1F, G protein-coupled
    serotonin receptor 1F

    NCBI Reference Sequences (RefSeq)

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    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_000866.5 → NP_000857.1  5-hydroxytryptamine receptor 1F

      See identical proteins and their annotated locations for NP_000857.1

      Status: VALIDATED

      Description
      Transcript Variant: Variants 1 through 4 encode the same protein.
      Source sequence(s)
      AC119733, AC132004, BC069125, BX357988, CA942616
      Consensus CDS
      CCDS2920.1
      UniProtKB/Swiss-Prot
      P30939
      UniProtKB/TrEMBL
      Q9P2Q4
      Conserved Domains (1) summary
      cd15334
      Location:24 → 359
      7tmA_5-HT1F; serotonin receptor subtype 1F, member of the class A family of seven-transmembrane G protein-coupled receptors

    2. NM_001322208.2 → NP_001309137.1  5-hydroxytryptamine receptor 1F

      Status: VALIDATED

      Description
      Transcript Variant: Variants 1 through 4 encode the same protein.
      Source sequence(s)
      AC117513, AC119034, AC119733
      Consensus CDS
      CCDS2920.1
      UniProtKB/Swiss-Prot
      P30939
      UniProtKB/TrEMBL
      Q9P2Q4
      Conserved Domains (1) summary
      cd15334
      Location:24 → 359
      7tmA_5-HT1F; serotonin receptor subtype 1F, member of the class A family of seven-transmembrane G protein-coupled receptors

    3. NM_001322209.2 → NP_001309138.1  5-hydroxytryptamine receptor 1F

      Status: VALIDATED

      Description
      Transcript Variant: Variants 1 through 4 encode the same protein.
      Source sequence(s)
      AC117513, AC119034, AC119733
      Consensus CDS
      CCDS2920.1
      UniProtKB/Swiss-Prot
      P30939
      UniProtKB/TrEMBL
      Q9P2Q4
      Related
      ENSP00000322924.4, ENST00000319595.7
      Conserved Domains (1) summary
      cd15334
      Location:24 → 359
      7tmA_5-HT1F; serotonin receptor subtype 1F, member of the class A family of seven-transmembrane G protein-coupled receptors

    4. NM_001322210.2 → NP_001309139.1  5-hydroxytryptamine receptor 1F

      Status: VALIDATED

      Description
      Transcript Variant: Variants 1 through 4 encode the same protein.
      Source sequence(s)
      AC117513, AC119034, AC119733
      Consensus CDS
      CCDS2920.1
      UniProtKB/Swiss-Prot
      P30939
      UniProtKB/TrEMBL
      Q9P2Q4
      Conserved Domains (1) summary
      cd15334
      Location:24 → 359
      7tmA_5-HT1F; serotonin receptor subtype 1F, member of the class A family of seven-transmembrane G protein-coupled receptors

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000003.12 Reference GRCh38.p14 Primary Assembly

      Range
      87792706..87993839
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_011533664.3 → XP_011531966.1  5-hydroxytryptamine receptor 1F isoform X1

      See identical proteins and their annotated locations for XP_011531966.1

      UniProtKB/Swiss-Prot
      P30939
      UniProtKB/TrEMBL
      Q9P2Q4
      Conserved Domains (1) summary
      cd15334
      Location:24 → 359
      7tmA_5-HT1F; serotonin receptor subtype 1F, member of the class A family of seven-transmembrane G protein-coupled receptors

    2. XM_005264751.4 → XP_005264808.1  5-hydroxytryptamine receptor 1F isoform X1

      See identical proteins and their annotated locations for XP_005264808.1

      UniProtKB/Swiss-Prot
      P30939
      UniProtKB/TrEMBL
      Q9P2Q4
      Conserved Domains (1) summary
      cd15334
      Location:24 → 359
      7tmA_5-HT1F; serotonin receptor subtype 1F, member of the class A family of seven-transmembrane G protein-coupled receptors

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060927.1 Alternate T2T-CHM13v2.0

      Range
      87868616..88069681
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054346412.1 → XP_054202387.1  5-hydroxytryptamine receptor 1F isoform X1

      UniProtKB/Swiss-Prot
      P30939

    2. XM_054346413.1 → XP_054202388.1  5-hydroxytryptamine receptor 1F isoform X1

      UniProtKB/Swiss-Prot
      P30939
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P30939.1 GenPept UniProtKB/Swiss-Prot:P30939

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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