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    Kat6b lysine acetyltransferase 6B [ Rattus norvegicus (Norway rat) ]

    Gene ID: 688634, updated on 2-Nov-2024

    Summary

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    Official Symbol
    Kat6bprovided by RGD
    Official Full Name
    lysine acetyltransferase 6Bprovided by RGD
    Primary source
    RGD:1566399
    See related
    EnsemblRapid:ENSRNOG00000012850 AllianceGenome:RGD:1566399
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    RGD1566399
    Summary
    Predicted to enable histone H3K14 acetyltransferase activity and transcription coactivator activity. Involved in positive regulation of transcription by RNA polymerase II. Predicted to be located in nucleus. Predicted to be part of MOZ/MORF histone acetyltransferase complex. Human ortholog(s) of this gene implicated in Ohdo syndrome, SBBYS variant; bipolar disorder; breast cancer; and leiomyoma. Orthologous to human KAT6B (lysine acetyltransferase 6B). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Biased expression in Adrenal (RPKM 52.2), Brain (RPKM 49.5) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Kat6b in Genome Data Viewer
    Location:
    15p16
    Exon count:
    21
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 15 NC_086033.1 (2688535..2861443, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 15 NC_051350.1 (2638885..2811977, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 15 NC_005114.4 (2811933..2966833, complement)

    Chromosome 15 - NC_086033.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC120096899 Neighboring gene uncharacterized LOC108352871 Neighboring gene dual specificity phosphatase 29 Neighboring gene uncharacterized LOC134482074 Neighboring gene uncharacterized LOC102553460 Neighboring gene U6 spliceosomal RNA Neighboring gene transfer RNA aspartic acid (anticodon AUC) 2 Neighboring gene adenosine kinase

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Can unknown predisposition in familial breast cancer be family-specific? Lynch H, et al. Breast J, 2013 Sep-Oct. PMID 23800003
    2. Uterine leiomyomata with t(10;17) disrupt the histone acetyltransferase MORF. Moore SD, et al. Cancer Res, 2004 Aug 15. PMID 15313893
    3. De novo mutations of the gene encoding the histone acetyltransferase KAT6B cause Genitopatellar syndrome. Simpson MA, et al. Am J Hum Genet, 2012 Feb 10. PMID 22265017, Free PMC Article
    4. Identification of a human histone acetyltransferase related to monocytic leukemia zinc finger protein. Champagne N, et al. J Biol Chem, 1999 Oct 1. PMID 10497217
    5. Identification of novel loci for bipolar I disorder in a multi-stage genome-wide association study. Kuo PH, et al. Prog Neuropsychopharmacol Biol Psychiatry, 2014 Jun 3. PMID 24444492

    See all (15) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables DNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables histone H3K14 acetyltransferase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables histone acetyltransferase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables peptide-lysine-N-acetyltransferase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables protein-containing complex binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables transcription coactivator activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within cellular response to leukemia inhibitory factor ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in negative regulation of DNA-templated transcription ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in nucleosome assembly IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in positive regulation of DNA-templated transcription ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of transcription by RNA polymerase II IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in regulation of DNA-templated transcription ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    part_of MOZ/MORF histone acetyltransferase complex ISO
    Inferred from Sequence Orthology
    more info
    		  
    part_of nucleosome IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nucleus ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    histone acetyltransferase KAT6B; lysine acetyltransferase 6B
    Names
    K(lysine) acetyltransferase 6B

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001433087.1 → NP_001420016.1  lysine acetyltransferase 6B isoform 1

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000015
      UniProtKB/TrEMBL
      A0A8I6GLZ3

    2. NM_001433088.1 → NP_001420017.1  lysine acetyltransferase 6B isoform 2

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000015

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086033.1 Reference GRCr8

      Range
      2688535..2861443 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_039093710.2 → XP_038949638.1  histone acetyltransferase KAT6B isoform X1

      UniProtKB/TrEMBL
      A0A8I6GLZ3
      Conserved Domains (4) summary
      smart00526
      Location:94 → 168
      H15; Domain in histone families 1 and 5
      PLN00104
      Location:721 → 989
      PLN00104; MYST -like histone acetyltransferase; Provisional
      cd15527
      Location:272 → 318
      PHD2_KAT6A_6B; PHD finger 2 found in monocytic leukemia zinc-finger protein (MOZ) and its factor (MORF)
      cd15618
      Location:213 → 270
      PHD1_MOZ_MORF; PHD finger 1 found in monocytic leukemia zinc-finger protein (MOZ) and its factor (MORF)

    2. XM_039093712.2 → XP_038949640.1  histone acetyltransferase KAT6B isoform X4

      Conserved Domains (4) summary
      smart00526
      Location:94 → 168
      H15; Domain in histone families 1 and 5
      PLN00104
      Location:430 → 698
      PLN00104; MYST -like histone acetyltransferase; Provisional
      cd15527
      Location:272 → 318
      PHD2_KAT6A_6B; PHD finger 2 found in monocytic leukemia zinc-finger protein (MOZ) and its factor (MORF)
      cl22851
      Location:213 → 271
      PHD_SF; PHD finger superfamily

    3. XM_039093707.2 → XP_038949635.1  histone acetyltransferase KAT6B isoform X1

      Conserved Domains (4) summary
      smart00526
      Location:94 → 168
      H15; Domain in histone families 1 and 5
      PLN00104
      Location:721 → 989
      PLN00104; MYST -like histone acetyltransferase; Provisional
      cd15527
      Location:272 → 318
      PHD2_KAT6A_6B; PHD finger 2 found in monocytic leukemia zinc-finger protein (MOZ) and its factor (MORF)
      cd15618
      Location:213 → 270
      PHD1_MOZ_MORF; PHD finger 1 found in monocytic leukemia zinc-finger protein (MOZ) and its factor (MORF)

    4. XM_039093713.2 → XP_038949641.1  histone acetyltransferase KAT6B isoform X5

      UniProtKB/TrEMBL
      A6KKS4
      Related
      ENSRNOP00000064386.4, ENSRNOT00000070893.4
      Conserved Domains (4) summary
      smart00526
      Location:94 → 168
      H15; Domain in histone families 1 and 5
      PLN00104
      Location:367 → 635
      PLN00104; MYST -like histone acetyltransferase; Provisional
      cd15527
      Location:272 → 310
      PHD2_KAT6A_6B; PHD finger 2 found in monocytic leukemia zinc-finger protein (MOZ) and its factor (MORF)
      cl22851
      Location:213 → 271
      PHD_SF; PHD finger superfamily

    5. XM_039093711.2 → XP_038949639.1  histone acetyltransferase KAT6B isoform X2

      UniProtKB/TrEMBL
      A6KKS4, M0R4T9
      Conserved Domains (4) summary
      smart00526
      Location:94 → 168
      H15; Domain in histone families 1 and 5
      PLN00104
      Location:539 → 807
      PLN00104; MYST -like histone acetyltransferase; Provisional
      cd15527
      Location:272 → 318
      PHD2_KAT6A_6B; PHD finger 2 found in monocytic leukemia zinc-finger protein (MOZ) and its factor (MORF)
      cl22851
      Location:213 → 271
      PHD_SF; PHD finger superfamily

    6. XM_063274843.1 → XP_063130913.1  histone acetyltransferase KAT6B isoform X6

    7. XM_063274842.1 → XP_063130912.1  histone acetyltransferase KAT6B isoform X5

    8. XM_063274841.1 → XP_063130911.1  histone acetyltransferase KAT6B isoform X4

    9. XM_063274839.1 → XP_063130909.1  histone acetyltransferase KAT6B isoform X2

      UniProtKB/TrEMBL
      M0R4T9

    10. XM_039093708.2 → XP_038949636.1  histone acetyltransferase KAT6B isoform X1

      UniProtKB/TrEMBL
      A0A8I6GLZ3
      Related
      ENSRNOP00000097238.1, ENSRNOT00000107992.2
      Conserved Domains (4) summary
      smart00526
      Location:94 → 168
      H15; Domain in histone families 1 and 5
      PLN00104
      Location:721 → 989
      PLN00104; MYST -like histone acetyltransferase; Provisional
      cd15527
      Location:272 → 318
      PHD2_KAT6A_6B; PHD finger 2 found in monocytic leukemia zinc-finger protein (MOZ) and its factor (MORF)
      cd15618
      Location:213 → 270
      PHD1_MOZ_MORF; PHD finger 1 found in monocytic leukemia zinc-finger protein (MOZ) and its factor (MORF)

    11. XM_039093709.2 → XP_038949637.1  histone acetyltransferase KAT6B isoform X1

      UniProtKB/TrEMBL
      A0A8I6GLZ3
      Conserved Domains (4) summary
      smart00526
      Location:94 → 168
      H15; Domain in histone families 1 and 5
      PLN00104
      Location:721 → 989
      PLN00104; MYST -like histone acetyltransferase; Provisional
      cd15527
      Location:272 → 318
      PHD2_KAT6A_6B; PHD finger 2 found in monocytic leukemia zinc-finger protein (MOZ) and its factor (MORF)
      cd15618
      Location:213 → 270
      PHD1_MOZ_MORF; PHD finger 1 found in monocytic leukemia zinc-finger protein (MOZ) and its factor (MORF)

    12. XM_063274840.1 → XP_063130910.1  histone acetyltransferase KAT6B isoform X3

    13. XM_039093716.2 → XP_038949644.1  histone acetyltransferase KAT6B isoform X7

      UniProtKB/TrEMBL
      A6KKS4
      Conserved Domains (1) summary
      PLN00104
      Location:45 → 313
      PLN00104; MYST -like histone acetyltransferase; Provisional
    Nucleotide Protein Strain
    Heading Accession and Version

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