CLIC4 chloride intracellular channel 4 [Homo sapiens (human)] - Gene

Summary

Official Symbol: CLIC4provided by HGNC
Official Full Name: chloride intracellular channel 4provided by HGNC
Primary source: HGNC:HGNC:13518
See related: Ensembl:ENSG00000169504 MIM:606536; AllianceGenome:HGNC:13518
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Homo sapiens
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as: H1; huH1; p64H1; CLIC4L; MTCLIC
Summary: Chloride channels are a diverse group of proteins that regulate fundamental cellular processes including stabilization of cell membrane potential, transepithelial transport, maintenance of intracellular pH, and regulation of cell volume. Chloride intracellular channel 4 (CLIC4) protein, encoded by the CLIC4 gene, is a member of the p64 family; the gene is expressed in many tissues and exhibits a intracellular vesicular pattern in Panc-1 cells (pancreatic cancer cells). [provided by RefSeq, Jul 2008]
Expression: Ubiquitous expression in endometrium (RPKM 129.1), kidney (RPKM 121.8) and 25 other tissues See more
Orthologs: mouse all
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Genomic context

Location:: 1p36.11

Exon count:: 6

Annotation release	Status	Assembly	Chr	Location
RS_2024_08	current	GRCh38.p14 (GCF_000001405.40)	1	NC_000001.11 (24745447..24844321)
RS_2024_08	current	T2T-CHM13v2.0 (GCF_009914755.1)	1	NC_060925.1 (24582409..24679995)
RS_2024_09	previous assembly	GRCh37.p13 (GCF_000001405.25)	1	NC_000001.10 (25071938..25170812)

Chromosome 1 - NC_000001.11 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: HPA RNA-seq normal tissues HPA RNA-seq normal tissues
Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
BioProject: PRJEB4337
Publication: PMID 24309898
Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

RNA-binding protein DND1 participates in migration, invasion, and EMT of prostate cancer cells by degrading CLIC4.
Title: RNA-binding protein DND1 participates in migration, invasion, and EMT of prostate cancer cells by degrading CLIC4.
Chloride intracellular channel 4 participates in the regulation of lipopolysaccharide-induced inflammatory responses in human bronchial epithelial cells.
Title: Chloride intracellular channel 4 participates in the regulation of lipopolysaccharide-induced inflammatory responses in human bronchial epithelial cells.
CLIC4 Function in the Epithelial-Mesenchymal Transition of Epithelial Odontogenic Lesions.
Title: CLIC4 Function in the Epithelial-Mesenchymal Transition of Epithelial Odontogenic Lesions.
CLIC4 Regulates Endothelial Barrier Control by Mediating PAR1 Signaling via RhoA.
Title: CLIC4 Regulates Endothelial Barrier Control by Mediating PAR1 Signaling via RhoA.
The stromal immunoexpression of CLIC4 may be related to the difference in the biological behavior between oral squamous cell carcinoma and oral verrucous carcinoma.
Title: The stromal immunoexpression of CLIC4 may be related to the difference in the biological behavior between oral squamous cell carcinoma and oral verrucous carcinoma.
Host CLIC4 expression in the tumor microenvironment is essential for breast cancer metastatic competence.
Title: Host CLIC4 expression in the tumor microenvironment is essential for breast cancer metastatic competence.
Requirement of CLIC4 Expression in Human Colorectal Cancer Cells for Sensitivity to Growth Inhibition by Fucoxanthinol.
Title: Requirement of CLIC4 Expression in Human Colorectal Cancer Cells for Sensitivity to Growth Inhibition by Fucoxanthinol.
Induction of Pro-Fibrotic CLIC4 in Dermal Fibroblasts by TGF-beta/Wnt3a Is Mediated by GLI2 Upregulation.
Title: Induction of Pro-Fibrotic CLIC4 in Dermal Fibroblasts by TGF-β/Wnt3a Is Mediated by GLI2 Upregulation.
Characterization of chloride intracellular channel 4 in the regulation of human trophoblast function.
Title: Characterization of chloride intracellular channel 4 in the regulation of human trophoblast function.
Circular RNA_0033596 aggravates endothelial cell injury induced by oxidized low-density lipoprotein via microRNA-217-5p /chloride intracellular channel 4 axis.
Title: Circular RNA_0033596 aggravates endothelial cell injury induced by oxidized low-density lipoprotein via microRNA-217-5p /chloride intracellular channel 4 axis.

Submit: New GeneRIF Correction See all GeneRIFs (49)

Phenotypes

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Review eQTL and phenotype association data in this region using PheGenI

EBI GWAS Catalog

Description
Hundreds of variants clustered in genomic loci and biological pathways affect human height. EBI GWAS Catalog EBI GWAS CatalogPubMed

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

RH12109 (e-PCR)
- UniSTS:91919

D1S234 (e-PCR), detects polymorphism
- UniSTS:48674

SHGC-74417 (e-PCR)
- UniSTS:9767

PMC133822P1 (e-PCR)
- UniSTS:270666

SHGC-142298 (e-PCR)
- UniSTS:171372

SHGC-60179 (e-PCR)
- UniSTS:9591

SHGC-74379 (e-PCR)
- UniSTS:81554

SHGC-74412 (e-PCR)
- UniSTS:41887

GDB:451688 (e-PCR)
- UniSTS:157346

G64279 (e-PCR)
- UniSTS:158659

SHGC-133015 (e-PCR)
- UniSTS:170974

Gene Ontology Provided by GOA

Function	Evidence Code	Pubs
enables chloride channel activity	IBA Inferred from Biological aspect of Ancestor more info
enables oxidoreductase activity	IEA Inferred from Electronic Annotation more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
involved_in angiogenesis	IEA Inferred from Electronic Annotation more info
involved_in branching morphogenesis of an epithelial tube	IEA Inferred from Electronic Annotation more info
involved_in cell differentiation	TAS Traceable Author Statement more info	PubMed
involved_in cellular response to calcium ion	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in chloride transmembrane transport	IEA Inferred from Electronic Annotation more info
involved_in chloride transport	IBA Inferred from Biological aspect of Ancestor more info
involved_in chloride transport	NAS Non-traceable Author Statement more info	PubMed
involved_in endothelial cell morphogenesis	IEA Inferred from Electronic Annotation more info
involved_in establishment or maintenance of apical/basal cell polarity	NAS Non-traceable Author Statement more info	PubMed
involved_in fertilization	IEA Inferred from Electronic Annotation more info
involved_in keratinocyte differentiation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in multicellular organism growth	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of cell migration	IDA Inferred from Direct Assay more info	PubMed
involved_in regulation of cytoskeleton organization	NAS Non-traceable Author Statement more info	PubMed
involved_in retina vasculature morphogenesis in camera-type eye	IEA Inferred from Electronic Annotation more info
involved_in vacuolar acidification	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in actin cytoskeleton	TAS Traceable Author Statement more info	PubMed
located_in apical part of cell	IDA Inferred from Direct Assay more info	PubMed
located_in cell surface	IDA Inferred from Direct Assay more info	PubMed
located_in cell-cell junction	IDA Inferred from Direct Assay more info	PubMed
located_in centrosome	IDA Inferred from Direct Assay more info	PubMed
part_of chloride channel complex	IEA Inferred from Electronic Annotation more info
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
located_in cytoplasm	IDA Inferred from Direct Assay more info	PubMed
located_in cytoplasmic vesicle membrane	IEA Inferred from Electronic Annotation more info
located_in cytosol	IDA Inferred from Direct Assay more info	PubMed
located_in endoplasmic reticulum membrane	IEA Inferred from Electronic Annotation more info
located_in extracellular exosome	HDA more info	PubMed
is_active_in membrane	IBA Inferred from Biological aspect of Ancestor more info
colocalizes_with microtubule cytoskeleton	IDA Inferred from Direct Assay more info	PubMed
located_in microvillus	IDA Inferred from Direct Assay more info	PubMed
located_in midbody	IDA Inferred from Direct Assay more info	PubMed
located_in mitochondrion	IDA Inferred from Direct Assay more info	PubMed
located_in nuclear matrix	IDA Inferred from Direct Assay more info	PubMed
located_in perinuclear region of cytoplasm	IDA Inferred from Direct Assay more info	PubMed
located_in plasma membrane	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: chloride intracellular channel protein 4

Names: chloride intracellular channel 4 like; epididymis secretory sperm binding protein; glutaredoxin-like oxidoreductase CLIC4; intracellular chloride ion channel protein p64H1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_013943.3 → NP_039234.1 chloride intracellular channel protein 4

See identical proteins and their annotated locations for NP_039234.1

Status: REVIEWED

Source sequence(s)

AL662924, BC012444, BQ574968, BQ929781

Consensus CDS

CCDS256.1

UniProtKB/Swiss-Prot

Q9UFW9, Q9UQJ6, Q9Y696

UniProtKB/TrEMBL

A0A024RAH9, B4DWC4, Q6FIC5

Related

ENSP00000363500.4, ENST00000374379.9

Conserved Domains (1) summary

TIGR00862
Location:17 → 252

O-ClC; intracellular chloride channel protein

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

NC_000001.11 Reference GRCh38.p14 Primary Assembly

Range

24745447..24844321

Download

GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

NC_060925.1 Alternate T2T-CHM13v2.0

Range

24582409..24679995

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_054335865.1 → XP_054191840.1 chloride intracellular channel protein 4 isoform X1

UniProtKB/Swiss-Prot

Q9UFW9, Q9UQJ6, Q9Y696

UniProtKB/TrEMBL

A0A024RAH9, Q6FIC5
XM_054335866.1 → XP_054191841.1 chloride intracellular channel protein 4 isoform X2