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    Krt17 keratin 17 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 287702, updated on 17-Aug-2024

    Summary

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    Official Symbol
    Krt17provided by RGD
    Official Full Name
    keratin 17provided by RGD
    Primary source
    RGD:1303181
    See related
    EnsemblRapid:ENSRNOG00000026371 AllianceGenome:RGD:1303181
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    Ka17
    Summary
    Predicted to be a structural constituent of cytoskeleton. Predicted to be involved in several processes, including hair follicle morphogenesis; positive regulation of hair follicle development; and positive regulation of translation. Predicted to act upstream of or within intermediate filament organization; keratinization; and morphogenesis of an epithelium. Predicted to be located in cell periphery; cytoplasm; and intermediate filament cytoskeleton. Human ortholog(s) of this gene implicated in ectodermal dysplasia; pachyonychia congenita; and steatocystoma multiplex. Orthologous to human KRT17 (keratin 17). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Restricted expression toward (RPKM 385.5) See more
    Orthologs
    human mouse all
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    Genomic context

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    Location:
    10q31
    Exon count:
    8
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 10 NC_086028.1 (85679068..85683792, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 10 NC_051345.1 (85178673..85183392, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 10 NC_005109.4 (88158993..88163712, complement)

    Chromosome 10 - NC_086028.1Genomic Context describing neighboring genes Neighboring gene type I keratin KA11 Neighboring gene keratin 16 Neighboring gene keratin 42 Neighboring gene uncharacterized LOC134480873

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Keratin 17 null mice exhibit age- and strain-dependent alopecia. McGowan KM, et al. Genes Dev, 2002 Jun 1. PMID 12050118, Free PMC Article
    2. A keratin cytoskeletal protein regulates protein synthesis and epithelial cell growth. Kim S, et al. Nature, 2006 May 18. PMID 16710422
    3. Keratin 16 and keratin 17 mutations cause pachyonychia congenita. McLean WH, et al. Nat Genet, 1995 Mar. PMID 7539673
    4. HLA DR B1*04, *07-restricted epitopes on Keratin 17 for autoreactive T cells in psoriasis. Shen Z, et al. J Dermatol Sci, 2005 Apr. PMID 15795121
    5. Tmem79/Matt is the matted mouse gene and is a predisposing gene for atopic dermatitis in human subjects. Saunders SP, et al. J Allergy Clin Immunol, 2013 Nov. PMID 24084074, Free PMC Article

    See all (14) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables structural constituent of cytoskeleton TAS
    Traceable Author Statement
    more info
    		 PubMed 
    enables structural molecule activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in epithelial cell differentiation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in hair follicle morphogenesis ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in hair follicle morphogenesis ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in intermediate filament organization IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within intermediate filament organization ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in intermediate filament-based process TAS
    Traceable Author Statement
    more info
    		 PubMed 
    acts_upstream_of_or_within keratinization ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within morphogenesis of an epithelium ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of cell growth ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of hair follicle development ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of translation ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    located_in cell periphery ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in cornified envelope ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in cytoskeleton IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in intermediate filament IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in intermediate filament TAS
    Traceable Author Statement
    more info
    		 PubMed 
    located_in intermediate filament cytoskeleton ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in keratin filament IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in keratin filament TAS
    Traceable Author Statement
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    keratin, type I cytoskeletal 17
    Names
    CK-17
    K17
    cytokeratin-17
    keratin 17, type I
    type I keratin KA17

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_212545.2 → NP_997710.1  keratin, type I cytoskeletal 17

      See identical proteins and their annotated locations for NP_997710.1

      Status: PROVISIONAL

      Source sequence(s)
      BC100058
      UniProtKB/Swiss-Prot
      Q6IFU8
      UniProtKB/TrEMBL
      A0A0G2K9Q9, A6HJ20
      Related
      ENSRNOP00000005382.5, ENSRNOT00000005382.8
      Conserved Domains (2) summary
      pfam00038
      Location:84 → 394
      Filament; Intermediate filament protein
      cl14876
      Location:215 → 296
      Zinc_peptidase_like; Zinc peptidases M18, M20, M28, and M42

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086028.1 Reference GRCr8

      Range
      85679068..85683792 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_063268733.1 → XP_063124803.1  keratin, type I cytoskeletal 17 isoform X1

      UniProtKB/TrEMBL
      A0A8I5ZN82
      Related
      ENSRNOP00000075091.2, ENSRNOT00000084493.3

    2. XM_039085609.1 → XP_038941537.1  keratin, type I cytoskeletal 17 isoform X2

      Conserved Domains (1) summary
      pfam00038
      Location:25 → 312
      Filament; Intermediate filament protein
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q6IFU8.1 GenPept UniProtKB/Swiss-Prot:Q6IFU8

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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