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    Nudt9 nudix hydrolase 9 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 305149, updated on 5-Mar-2024

    Summary

    Official Symbol
    Nudt9provided by RGD
    Official Full Name
    nudix hydrolase 9provided by RGD
    Primary source
    RGD:1359522
    See related
    Ensembl:ENSRNOG00000002186 AllianceGenome:RGD:1359522
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Predicted to enable ADP-ribose diphosphatase activity. Predicted to act upstream of or within ADP catabolic process and IDP catabolic process. Predicted to be located in cell junction; nuclear body; and nuclear membrane. Predicted to be active in mitochondrion. Orthologous to human NUDT9 (nudix hydrolase 9). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Biased expression in Testes (RPKM 144.3), Brain (RPKM 103.7) and 9 other tissues See more
    Orthologs
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    Genomic context

    See Nudt9 in Genome Data Viewer
    Location:
    14p22
    Exon count:
    9
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 14 NC_086032.1 (5980042..5997998, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 14 NC_051349.1 (5675376..5693332, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 14 NC_005113.4 (7036809..7054739, complement)

    Chromosome 14 - NC_086032.1Genomic Context describing neighboring genes Neighboring gene SPARC like 1 Neighboring gene secretory calcium-binding phosphoprotein proline-glutamine rich 1 Neighboring gene hydroxysteroid (17-beta) dehydrogenase 11 Neighboring gene hydroxysteroid (17-beta) dehydrogenase 13 Neighboring gene uncharacterized LOC120096561 Neighboring gene kelch-like family member 8

    Genomic regions, transcripts, and products

    Expression

    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Pathways from PubChem

    General gene information

    Markers

    Clone Names

    • MGC94618

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables ADP-ribose diphosphatase activity ISO
    Inferred from Sequence Orthology
    more info
     
    Process Evidence Code Pubs
    acts_upstream_of_or_within ADP catabolic process ISO
    Inferred from Sequence Orthology
    more info
     
    Component Evidence Code Pubs
    located_in cell junction IEA
    Inferred from Electronic Annotation
    more info
     
    located_in cell junction ISO
    Inferred from Sequence Orthology
    more info
     
    is_active_in mitochondrion IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in mitochondrion ISO
    Inferred from Sequence Orthology
    more info
     
    located_in nuclear body IEA
    Inferred from Electronic Annotation
    more info
     
    located_in nuclear body ISO
    Inferred from Sequence Orthology
    more info
     
    located_in nuclear membrane IEA
    Inferred from Electronic Annotation
    more info
     
    located_in nuclear membrane ISO
    Inferred from Sequence Orthology
    more info
     

    General protein information

    Preferred Names
    ADP-ribose pyrophosphatase, mitochondrial
    Names
    ADP-ribose diphosphatase
    ADP-ribose phosphohydrolase
    ADPR-PPase
    adenosine diphosphoribose pyrophosphatase
    nucleoside diphosphate-linked moiety X motif 9
    nudix (nucleoside diphosphate linked moiety X)-type motif 9
    nudix motif 9
    nudix-type motif 9
    NP_001006992.1
    XP_006250692.1
    XP_006250693.1
    XP_017454652.1

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001006991.1NP_001006992.1  ADP-ribose pyrophosphatase, mitochondrial

      See identical proteins and their annotated locations for NP_001006992.1

      Status: PROVISIONAL

      Source sequence(s)
      BC083722
      UniProtKB/Swiss-Prot
      Q5XIG0
      Related
      ENSRNOP00000002973.3, ENSRNOT00000002973.5
      Conserved Domains (1) summary
      cd03670
      Location:149335
      ADPRase_NUDT9; ADP-ribose pyrophosphatase (ADPRase) catalyzes the hydrolysis of ADP-ribose to AMP and ribose-5-P. Like other members of the Nudix hydrolase superfamily of enzymes, it is thought to require a divalent cation, such as Mg2+, for its activity. It also ...

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086032.1 Reference GRCr8

      Range
      5980042..5997998 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006250630.4XP_006250692.1  ADP-ribose pyrophosphatase, mitochondrial isoform X1

      See identical proteins and their annotated locations for XP_006250692.1

      UniProtKB/TrEMBL
      A6K5T5
      Conserved Domains (1) summary
      cd03670
      Location:99285
      ADPRase_NUDT9; ADP-ribose pyrophosphatase (ADPRase) catalyzes the hydrolysis of ADP-ribose to AMP and ribose-5-P. Like other members of the Nudix hydrolase superfamily of enzymes, it is thought to require a divalent cation, such as Mg2+, for its activity. It also ...
    2. XM_006250631.5XP_006250693.1  ADP-ribose pyrophosphatase, mitochondrial isoform X1

      See identical proteins and their annotated locations for XP_006250693.1

      UniProtKB/TrEMBL
      A6K5T5
      Conserved Domains (1) summary
      cd03670
      Location:99285
      ADPRase_NUDT9; ADP-ribose pyrophosphatase (ADPRase) catalyzes the hydrolysis of ADP-ribose to AMP and ribose-5-P. Like other members of the Nudix hydrolase superfamily of enzymes, it is thought to require a divalent cation, such as Mg2+, for its activity. It also ...
    3. XM_017599163.3XP_017454652.1  ADP-ribose pyrophosphatase, mitochondrial isoform X2