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    Tmem63c transmembrane protein 63c [ Rattus norvegicus (Norway rat) ]

    Gene ID: 314332, updated on 2-Nov-2024

    Summary

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    Official Symbol
    Tmem63cprovided by RGD
    Official Full Name
    transmembrane protein 63cprovided by RGD
    Primary source
    RGD:1310207
    See related
    EnsemblRapid:ENSRNOG00000011334 AllianceGenome:RGD:1310207
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    RGD1310207
    Summary
    Predicted to enable calcium-activated cation channel activity and osmolarity-sensing monoatomic cation channel activity. Involved in glomerular filtration. Predicted to be located in endoplasmic reticulum membrane. Predicted to be active in plasma membrane. Human ortholog(s) of this gene implicated in hereditary spastic paraplegia 87. Orthologous to human TMEM63C (transmembrane protein 63C). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Biased expression in Brain (RPKM 59.7), Spleen (RPKM 20.5) and 5 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Tmem63c in Genome Data Viewer
    Location:
    6q31
    Exon count:
    32
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 6 NC_086024.1 (112398308..112469732)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 6 NC_051341.1 (106667389..106738778)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 6 NC_005105.4 (111044099..111120659)

    Chromosome 6 - NC_086024.1Genomic Context describing neighboring genes Neighboring gene CLOCK-interacting pacemaker Neighboring gene transfer RNA glycine (anticodon ACC) Neighboring gene zinc finger DHHC-type palmitoyltransferase 22 Neighboring gene neuroglobin Neighboring gene uncharacterized LOC134479237 Neighboring gene protein-O-mannosyltransferase 2

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Analysis of the genomic architecture of a complex trait locus in hypertensive rat models links Tmem63c to kidney damage. Schulz A, et al. Elife, 2019 Mar 22. PMID 30900988, Free PMC Article
    2. DUF221 proteins are a family of osmosensitive calcium-permeable cation channels conserved across eukaryotes. Hou C, et al. Cell Res, 2014 May. PMID 24503647, Free PMC Article
    3. Co-expression of mouse TMEM63A, TMEM63B and TMEM63C confers hyperosmolarity activated ion currents in HEK293 cells. Zhao X, et al. Cell Biochem Funct, 2016 Jun. PMID 27045885
    4. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Tmem63c is differentially expressed in glomeruli of allele-specific rat models during onset of albuminuria.
      Title: Analysis of the genomic architecture of a complex trait locus in hypertensive rat models links Tmem63c to kidney damage.
    Submit: New GeneRIF Correction

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables calcium-activated cation channel activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables calcium-activated cation channel activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables calcium-activated cation channel activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables osmolarity-sensing monoatomic cation channel activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables osmolarity-sensing monoatomic cation channel activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Process Evidence Code Pubs
    involved_in glomerular filtration IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in monoatomic cation transmembrane transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in monoatomic cation transport ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    located_in endoplasmic reticulum membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in plasma membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in plasma membrane ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  

    General protein information

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    Preferred Names
    calcium permeable stress-gated cation channel 1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001108045.1 → NP_001101515.1  calcium permeable stress-gated cation channel 1

      See identical proteins and their annotated locations for NP_001101515.1

      Status: PROVISIONAL

      Source sequence(s)
      CH473982
      UniProtKB/Swiss-Prot
      D3ZNF5
      UniProtKB/TrEMBL
      A0A8L2QZP2
      Related
      ENSRNOP00000079813.2, ENSRNOT00000106610.2
      Conserved Domains (3) summary
      pfam02714
      Location:407 → 678
      RSN1_7TM; Calcium-dependent channel, 7TM region, putative phosphate
      pfam13967
      Location:38 → 195
      RSN1_TM; Late exocytosis, associated with Golgi transport
      pfam14703
      Location:218 → 396
      PHM7_cyt; Cytosolic domain of 10TM putative phosphate transporter

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086024.1 Reference GRCr8

      Range
      112398308..112469732
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_063261951.1 → XP_063118021.1  calcium permeable stress-gated cation channel 1 isoform X1

      UniProtKB/Swiss-Prot
      D3ZNF5

    2. XM_006240384.4 → XP_006240446.1  calcium permeable stress-gated cation channel 1 isoform X1

      See identical proteins and their annotated locations for XP_006240446.1

      UniProtKB/Swiss-Prot
      D3ZNF5
      UniProtKB/TrEMBL
      A0A8L2QZP2
      Conserved Domains (3) summary
      pfam02714
      Location:407 → 678
      RSN1_7TM; Calcium-dependent channel, 7TM region, putative phosphate
      pfam13967
      Location:38 → 195
      RSN1_TM; Late exocytosis, associated with Golgi transport
      pfam14703
      Location:218 → 396
      PHM7_cyt; Cytosolic domain of 10TM putative phosphate transporter

    3. XM_063261950.1 → XP_063118020.1  calcium permeable stress-gated cation channel 1 isoform X1

      UniProtKB/Swiss-Prot
      D3ZNF5

    4. XM_006240386.5 → XP_006240448.1  calcium permeable stress-gated cation channel 1 isoform X1

      See identical proteins and their annotated locations for XP_006240448.1

      UniProtKB/Swiss-Prot
      D3ZNF5
      UniProtKB/TrEMBL
      A0A8L2QZP2
      Conserved Domains (3) summary
      pfam02714
      Location:407 → 678
      RSN1_7TM; Calcium-dependent channel, 7TM region, putative phosphate
      pfam13967
      Location:38 → 195
      RSN1_TM; Late exocytosis, associated with Golgi transport
      pfam14703
      Location:218 → 396
      PHM7_cyt; Cytosolic domain of 10TM putative phosphate transporter

    5. XM_063261948.1 → XP_063118018.1  calcium permeable stress-gated cation channel 1 isoform X1

      UniProtKB/Swiss-Prot
      D3ZNF5

    6. XM_039112327.2 → XP_038968255.1  calcium permeable stress-gated cation channel 1 isoform X1

      UniProtKB/Swiss-Prot
      D3ZNF5
      UniProtKB/TrEMBL
      A0A8L2QZP2
      Conserved Domains (3) summary
      pfam02714
      Location:407 → 678
      RSN1_7TM; Calcium-dependent channel, 7TM region, putative phosphate
      pfam13967
      Location:38 → 195
      RSN1_TM; Late exocytosis, associated with Golgi transport
      pfam14703
      Location:218 → 396
      PHM7_cyt; Cytosolic domain of 10TM putative phosphate transporter

    7. XM_039112326.2 → XP_038968254.1  calcium permeable stress-gated cation channel 1 isoform X1

      UniProtKB/Swiss-Prot
      D3ZNF5
      UniProtKB/TrEMBL
      A0A8L2QZP2
      Conserved Domains (3) summary
      pfam02714
      Location:407 → 678
      RSN1_7TM; Calcium-dependent channel, 7TM region, putative phosphate
      pfam13967
      Location:38 → 195
      RSN1_TM; Late exocytosis, associated with Golgi transport
      pfam14703
      Location:218 → 396
      PHM7_cyt; Cytosolic domain of 10TM putative phosphate transporter

    8. XM_006240385.5 → XP_006240447.1  calcium permeable stress-gated cation channel 1 isoform X1

      See identical proteins and their annotated locations for XP_006240447.1

      UniProtKB/Swiss-Prot
      D3ZNF5
      UniProtKB/TrEMBL
      A0A8L2QZP2
      Conserved Domains (3) summary
      pfam02714
      Location:407 → 678
      RSN1_7TM; Calcium-dependent channel, 7TM region, putative phosphate
      pfam13967
      Location:38 → 195
      RSN1_TM; Late exocytosis, associated with Golgi transport
      pfam14703
      Location:218 → 396
      PHM7_cyt; Cytosolic domain of 10TM putative phosphate transporter

    9. XM_017594159.3 → XP_017449648.1  calcium permeable stress-gated cation channel 1 isoform X1

      UniProtKB/Swiss-Prot
      D3ZNF5
      UniProtKB/TrEMBL
      A0A8L2QZP2
      Conserved Domains (3) summary
      pfam02714
      Location:407 → 678
      RSN1_7TM; Calcium-dependent channel, 7TM region, putative phosphate
      pfam13967
      Location:38 → 195
      RSN1_TM; Late exocytosis, associated with Golgi transport
      pfam14703
      Location:218 → 396
      PHM7_cyt; Cytosolic domain of 10TM putative phosphate transporter

    10. XM_006240382.5 → XP_006240444.1  calcium permeable stress-gated cation channel 1 isoform X1

      See identical proteins and their annotated locations for XP_006240444.1

      UniProtKB/Swiss-Prot
      D3ZNF5
      UniProtKB/TrEMBL
      A0A8L2QZP2
      Conserved Domains (3) summary
      pfam02714
      Location:407 → 678
      RSN1_7TM; Calcium-dependent channel, 7TM region, putative phosphate
      pfam13967
      Location:38 → 195
      RSN1_TM; Late exocytosis, associated with Golgi transport
      pfam14703
      Location:218 → 396
      PHM7_cyt; Cytosolic domain of 10TM putative phosphate transporter

    11. XM_017594161.3 → XP_017449650.1  calcium permeable stress-gated cation channel 1 isoform X1

      UniProtKB/Swiss-Prot
      D3ZNF5
      UniProtKB/TrEMBL
      A0A8L2QZP2
      Conserved Domains (3) summary
      pfam02714
      Location:407 → 678
      RSN1_7TM; Calcium-dependent channel, 7TM region, putative phosphate
      pfam13967
      Location:38 → 195
      RSN1_TM; Late exocytosis, associated with Golgi transport
      pfam14703
      Location:218 → 396
      PHM7_cyt; Cytosolic domain of 10TM putative phosphate transporter

    12. XM_006240389.5 → XP_006240451.1  calcium permeable stress-gated cation channel 1 isoform X1

      See identical proteins and their annotated locations for XP_006240451.1

      UniProtKB/Swiss-Prot
      D3ZNF5
      UniProtKB/TrEMBL
      A0A8L2QZP2
      Conserved Domains (3) summary
      pfam02714
      Location:407 → 678
      RSN1_7TM; Calcium-dependent channel, 7TM region, putative phosphate
      pfam13967
      Location:38 → 195
      RSN1_TM; Late exocytosis, associated with Golgi transport
      pfam14703
      Location:218 → 396
      PHM7_cyt; Cytosolic domain of 10TM putative phosphate transporter

    13. XM_039112330.2 → XP_038968258.1  calcium permeable stress-gated cation channel 1 isoform X4

      Conserved Domains (3) summary
      pfam02714
      Location:407 → 515
      RSN1_7TM; Calcium-dependent channel, 7TM region, putative phosphate
      pfam13967
      Location:38 → 195
      RSN1_TM; Late exocytosis, associated with Golgi transport
      pfam14703
      Location:218 → 396
      PHM7_cyt; Cytosolic domain of 10TM putative phosphate transporter

    14. XM_017594158.3 → XP_017449647.1  calcium permeable stress-gated cation channel 1 isoform X1

      UniProtKB/Swiss-Prot
      D3ZNF5
      UniProtKB/TrEMBL
      A0A8L2QZP2
      Conserved Domains (3) summary
      pfam02714
      Location:407 → 678
      RSN1_7TM; Calcium-dependent channel, 7TM region, putative phosphate
      pfam13967
      Location:38 → 195
      RSN1_TM; Late exocytosis, associated with Golgi transport
      pfam14703
      Location:218 → 396
      PHM7_cyt; Cytosolic domain of 10TM putative phosphate transporter

    15. XM_006240383.5 → XP_006240445.1  calcium permeable stress-gated cation channel 1 isoform X1

      See identical proteins and their annotated locations for XP_006240445.1

      UniProtKB/Swiss-Prot
      D3ZNF5
      UniProtKB/TrEMBL
      A0A8L2QZP2
      Conserved Domains (3) summary
      pfam02714
      Location:407 → 678
      RSN1_7TM; Calcium-dependent channel, 7TM region, putative phosphate
      pfam13967
      Location:38 → 195
      RSN1_TM; Late exocytosis, associated with Golgi transport
      pfam14703
      Location:218 → 396
      PHM7_cyt; Cytosolic domain of 10TM putative phosphate transporter

    16. XM_006240387.5 → XP_006240449.1  calcium permeable stress-gated cation channel 1 isoform X1

      See identical proteins and their annotated locations for XP_006240449.1

      UniProtKB/Swiss-Prot
      D3ZNF5
      UniProtKB/TrEMBL
      A0A8L2QZP2
      Conserved Domains (3) summary
      pfam02714
      Location:407 → 678
      RSN1_7TM; Calcium-dependent channel, 7TM region, putative phosphate
      pfam13967
      Location:38 → 195
      RSN1_TM; Late exocytosis, associated with Golgi transport
      pfam14703
      Location:218 → 396
      PHM7_cyt; Cytosolic domain of 10TM putative phosphate transporter

    17. XM_006240390.4 → XP_006240452.1  calcium permeable stress-gated cation channel 1 isoform X2

      Conserved Domains (2) summary
      pfam02714
      Location:217 → 556
      RSN1_7TM; Calcium-dependent channel, 7TM region, putative phosphate
      pfam14703
      Location:129 → 199
      PHM7_cyt; Cytosolic domain of 10TM putative phosphate transporter

    18. XM_039112328.2 → XP_038968256.1  calcium permeable stress-gated cation channel 1 isoform X3

      Conserved Domains (2) summary
      pfam02714
      Location:187 → 458
      RSN1_7TM; Calcium-dependent channel, 7TM region, putative phosphate
      pfam14703
      Location:1 → 176
      PHM7_cyt; Cytosolic domain of 10TM putative phosphate transporter

    RNA

    1. XR_010052096.1 RNA Sequence

    2. XR_005505527.2 RNA Sequence

    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    D3ZNF5.1 GenPept UniProtKB/Swiss-Prot:D3ZNF5

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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