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    Loricrin loricrin cornified envelope precursor protein [ Rattus norvegicus (Norway rat) ]

    Gene ID: 502541, updated on 2-Nov-2024

    Summary

    Official Symbol
    Loricrinprovided by RGD
    Official Full Name
    loricrin cornified envelope precursor proteinprovided by RGD
    Primary source
    RGD:1559993
    See related
    EnsemblRapid:ENSRNOG00000059604 AllianceGenome:RGD:1559993
    Gene type
    protein coding
    RefSeq status
    INFERRED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    Lor; RGD1559993
    Summary
    Predicted to be a structural constituent of cytoskeleton and structural constituent of skin epidermis. Predicted to be involved in keratinocyte differentiation and peptide cross-linking. Predicted to be located in cytoplasm and cytoplasmic side of plasma membrane. Predicted to be active in cornified envelope. Orthologous to human LORICRIN (loricrin cornified envelope precursor protein). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Biased expression in Lung (RPKM 9.2) and Brain (RPKM 4.0) See more
    Orthologs
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    Genomic context

    See Loricrin in Genome Data Viewer
    Location:
    2q34
    Exon count:
    2
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 2 NC_086020.1 (180253674..180256572, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 2 NC_051337.1 (177558062..177560960, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 2 NC_005101.4 (191984455..191990713, complement)

    Chromosome 2 - NC_086020.1Genomic Context describing neighboring genes Neighboring gene phosphate cytidylyltransferase 1A, choline, pseudogene 3 Neighboring gene 14-3-3 protein theta-like Neighboring gene proline rich 9 Neighboring gene small proline-rich protein 2A2

    Genomic regions, transcripts, and products

    Expression

    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    General gene information

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables structural constituent of cytoskeleton ISO
    Inferred from Sequence Orthology
    more info
     
    enables structural constituent of skin epidermis ISO
    Inferred from Sequence Orthology
    more info
     
    Process Evidence Code Pubs
    involved_in cytoskeleton organization IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in keratinocyte differentiation ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in peptide cross-linking ISO
    Inferred from Sequence Orthology
    more info
     
    Component Evidence Code Pubs
    is_active_in cornified envelope ISO
    Inferred from Sequence Orthology
    more info
     
    located_in cornified envelope ISO
    Inferred from Sequence Orthology
    more info
     
    located_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    located_in cytoplasmic side of plasma membrane ISO
    Inferred from Sequence Orthology
    more info
     

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001399507.1NP_001386436.1  loricrin

      Status: INFERRED

      Source sequence(s)
      JAXUCZ010000002
      Related
      ENSRNOP00000070322.3, ENSRNOT00000090155.3

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086020.1 Reference GRCr8

      Range
      180253674..180256572 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)