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    trr1 thioredoxin reductase Trr1 [ Schizosaccharomyces pombe (fission yeast) ]

    Gene ID: 3361358, updated on 18-Sep-2024

    Summary

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    Official Symbol
    trr1
    Official Full Name
    thioredoxin reductase Trr1
    Primary source
    PomBase:SPBC3F6.03
    Locus tag
    SPOM_SPBC3F6.03
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Schizosaccharomyces pombe (strain: 972h-)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Taphrinomycotina; Schizosaccharomycetes; Schizosaccharomycetales; Schizosaccharomycetaceae; Schizosaccharomyces
    Also known as
    caf4; trxR
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    Genomic context

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    See trr1 in Genome Data Viewer
    Location:
    chromosome: II
    Exon count:
    2
    Sequence:
    Chromosome: II; NC_003423.3 (4189799..4191448)

    Chromosome II - NC_003423.3Genomic Context describing neighboring genes Neighboring gene ncRNA Neighboring gene 3 beta-hydroxysteroid dehydrogenase/delta 5-to-4-isomerase Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene U3 snoRNP protein Nop14

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003423.3

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Stress-dependent regulation of the gene encoding thioredoxin reductase from the fission yeast. Hong SM, et al. FEMS Microbiol Lett, 2004 May 15. PMID 15135546
    2. Lack of a peroxiredoxin suppresses the lethality of cells devoid of electron donors by channelling electrons to oxidized ribonucleotide reductase. Boronat S, et al. PLoS Genet, 2017 Jun. PMID 28640807, Free PMC Article
    3. Is oxidized thioredoxin a major trigger for cysteine oxidation? Clues from a redox proteomics approach. García-Santamarina S, et al. Antioxid Redox Signal, 2013 May 1. PMID 23121505, Free PMC Article
    4. The peroxiredoxin Tpx1 is essential as a H2O2 scavenger during aerobic growth in fission yeast. Jara M, et al. Mol Biol Cell, 2007 Jun. PMID 17409354, Free PMC Article
    5. A peroxiredoxin promotes H2O2 signaling and oxidative stress resistance by oxidizing a thioredoxin family protein. Brown JD, et al. Cell Rep, 2013 Dec 12. PMID 24268782, Free PMC Article

    See all (15) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by PomBase

    Function Evidence Code Pubs
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables thioredoxin-disulfide reductase (NADPH) activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables thioredoxin-disulfide reductase (NADPH) activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables thioredoxin-disulfide reductase (NADPH) activity IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in cell redox homeostasis IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in removal of superoxide radicals IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cytosol HDA PubMed 
    is_active_in cytosol IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in mitochondrion ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    is_active_in nucleus HDA PubMed 

    General protein information

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    Preferred Names
    thioredoxin reductase Trr1

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003423.3 Reference assembly

      Range
      4189799..4191448
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001022668.3 → NP_001018848.1  thioredoxin reductase Trr1 [Schizosaccharomyces pombe]

      See identical proteins and their annotated locations for NP_001018848.1

      Status: PROVISIONAL

      UniProtKB/Swiss-Prot
      Q92375
      Conserved Domains (3) summary
      TIGR01292
      Location:5 → 315
      TRX_reduct; thioredoxin-disulfide reductase
      pfam00070
      Location:157 → 221
      Pyr_redox; Pyridine nucleotide-disulphide oxidoreductase
      cl21454
      Location:6 → 124
      NADB_Rossmann; Rossmann-fold NAD(P)(+)-binding proteins
    Nucleotide Protein
    Heading Accession and Version

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