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    moa1 meikin [ Schizosaccharomyces pombe (fission yeast) ]

    Gene ID: 2542808, updated on 18-Sep-2024

    Summary

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    Official Symbol
    moa1
    Official Full Name
    meikin
    Primary source
    PomBase:SPAC15E1.07c
    Locus tag
    SPOM_SPAC15E1.07C
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Schizosaccharomyces pombe (strain: 972h-)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Taphrinomycotina; Schizosaccharomycetes; Schizosaccharomycetales; Schizosaccharomycetaceae; Schizosaccharomyces
    Also known as
    mug159
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    Genomic context

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    See moa1 in Genome Data Viewer
    Location:
    chromosome: I
    Exon count:
    1
    Sequence:
    Chromosome: I; NC_003424.3 (3728516..3729034, complement)

    Chromosome I - NC_003424.3Genomic Context describing neighboring genes Neighboring gene thymidylate synthase Neighboring gene ethanolamine-phosphate cytidylyltransferase Neighboring gene retromer complex subunit Vps29 Neighboring gene ncRNA Neighboring gene NatA N-acetyltransferase complex catalytic subunit Naa10

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003424.3

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Cohesins determine the attachment manner of kinetochores to spindle microtubules at meiosis I in fission yeast. Yokobayashi S, et al. Mol Cell Biol, 2003 Jun. PMID 12748297, Free PMC Article
    2. Structures of CENP-C cupin domains at regional centromeres reveal unique patterns of dimerization and recruitment functions for the inner pocket. Chik JK, et al. J Biol Chem, 2019 Sep 20. PMID 31366733, Free PMC Article
    3. The kinetochore protein Moa1 enables cohesion-mediated monopolar attachment at meiosis I. Yokobayashi S, et al. Cell, 2005 Dec 2. PMID 16325576
    4. Phosphorylation of Rec8 cohesin complexes regulates mono-orientation of kinetochores in meiosis I. Liu Y, et al. Life Sci Alliance, 2024 May. PMID 38448160, Free PMC Article
    5. Acetylation regulates monopolar attachment at multiple levels during meiosis I in fission yeast. Kagami A, et al. EMBO Rep, 2011 Oct 28. PMID 21979813, Free PMC Article

    See all (21) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Study shows that fission yeast Moa1 (meikin), which associates stably with CENP-C during meiosis I, recruits Plo1 (polo-like kinase) to the kinetochores and phosphorylates Spc7 (KNL1) to accumulate Bub1. Consequently, in contrast to the transient kinetochore localization of mitotic Bub1, meiotic Bub1 persists at kinetochores until anaphase I.
      Title: Meikin-associated polo-like kinase specifies Bub1 distribution in meiosis I.
    2. Moa1 is meiosis specific, localizes exclusively to the centromeric central core, and interacts with Rec8. It is required for monopolar attachment. Data suggests that Moa1 functions only through Rec8 to facilitate cohesion at the central core. [Moa1]
      Title: The kinetochore protein Moa1 enables cohesion-mediated monopolar attachment at meiosis I.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by PomBase

    Function Evidence Code Pubs
    enables kinetochore adaptor activity EXP
    Inferred from Experiment
    more info
    		 PubMed 
    enables kinetochore adaptor activity IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in homologous chromosome orientation in meiotic metaphase I IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in meiotic cell cycle IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in meiotic centromeric cohesion protection in anaphase I EXP
    Inferred from Experiment
    more info
    		 PubMed 
    involved_in meiotic centromeric cohesion protection in anaphase I IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in meiotic chromosome segregation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in spindle attachment to meiosis I kinetochore EXP
    Inferred from Experiment
    more info
    		 PubMed 
    involved_in spindle attachment to meiosis I kinetochore IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    is_active_in CENP-A containing chromatin IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in kinetochore IC
    Inferred by Curator
    more info
    		  
    is_active_in nucleus IC
    Inferred by Curator
    more info
    		  

    General protein information

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    Preferred Names
    meikin

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003424.3 Reference assembly

      Range
      3728516..3729034 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001019731.1 → NP_594308.1  meikin [Schizosaccharomyces pombe]

      See identical proteins and their annotated locations for NP_594308.1

      Status: PROVISIONAL

      UniProtKB/Swiss-Prot
      Q9UTI4
    Nucleotide Protein
    Heading Accession and Version

    Gene LinkOut

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    Molecular Biology Databases
    Research Materials