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    HOM6 homoserine dehydrogenase [ Saccharomyces cerevisiae S288C ]

    Gene ID: 853604, updated on 17-May-2024

    Summary

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    Gene symbol
    HOM6
    Gene description
    homoserine dehydrogenase
    Primary source
    FungiDB:YJR139C
    Locus tag
    YJR139C
    See related
    SGD:S000003900; AllianceGenome:SGD:S000003900
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Also known as
    THR6
    Summary
    Enables homoserine dehydrogenase activity. Involved in homoserine biosynthetic process; methionine biosynthetic process; and threonine biosynthetic process. Located in cytoplasm and nucleus. [provided by Alliance of Genome Resources, Apr 2022]
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    Genomic context

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    See HOM6 in Genome Data Viewer
    Location:
    chromosome: X
    Exon count:
    1
    Sequence:
    Chromosome: X; NC_001142.9 (689445..690524, complement)

    Chromosome X - NC_001142.9Genomic Context describing neighboring genes Neighboring gene sulfite reductase (NADPH) subunit beta Neighboring gene GTPase-activating protein IML1 Neighboring gene Hir3p Neighboring gene putative polyadenylation protein

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001142.9

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Effects of metal ions and hydrogen peroxide on the phenotype of yeast hom6Δ mutant. Tun NM, et al. Lett Appl Microbiol, 2015 Jan. PMID 25284025
    2. New phenolic inhibitors of yeast homoserine dehydrogenase. Ejim L, et al. Bioorg Med Chem, 2004 Jul 15. PMID 15210149
    3. Enzyme-assisted suicide: molecular basis for the antifungal activity of 5-hydroxy-4-oxonorvaline by potent inhibition of homoserine dehydrogenase. Jacques SL, et al. Chem Biol, 2003 Oct. PMID 14583265
    4. Homoserine dehydrogenase from Saccharomyces cerevisiae: kinetic mechanism and stereochemistry of hydride transfer. Jacques SL, et al. Biochim Biophys Acta, 2001 Jan 12. PMID 11341915
    5. Characterization of yeast homoserine dehydrogenase, an antifungal target: the invariant histidine 309 is important for enzyme integrity. Jacques SL, et al. Biochim Biophys Acta, 2001 Jan 12. PMID 11341914

    See all (81) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables NADP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables homoserine dehydrogenase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables homoserine dehydrogenase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables homoserine dehydrogenase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables oxidoreductase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in aspartate family amino acid biosynthetic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in aspartate family amino acid biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in homoserine biosynthetic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in homoserine biosynthetic process IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in isoleucine biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in methionine biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in methionine biosynthetic process IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in threonine biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in threonine biosynthetic process IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in cytoplasm HDA PubMed 
    located_in nucleus HDA PubMed 

    General protein information

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    Preferred Names
    homoserine dehydrogenase
    NP_012673.3
    • Homoserine dehydrogenase (L-homoserine:NADP oxidoreductase); dimeric enzyme that catalyzes the third step in the common pathway for methionine and threonine biosynthesis; enzyme has nucleotide-binding, dimerization and catalytic regions

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001142.9 Reference assembly

      Range
      689445..690524 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001181797.3 → NP_012673.3  TPA: homoserine dehydrogenase [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_012673.3

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D6VWV8, P31116
      UniProtKB/TrEMBL
      A0A6A5PTT7, A6ZQ95, B3LQM1, B5VLS9, C7GM73, C8ZBT8, E9P9D5, G2WHE2, N1P1T8
      Conserved Domains (1) summary
      PRK09436
      Location:2 → 335
      thrA; bifunctional aspartokinase I/homoserine dehydrogenase I; Provisional
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P31116.1

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