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    GCD2 translation initiation factor eIF2B subunit delta [ Saccharomyces cerevisiae S288C ]

    Gene ID: 852974, updated on 2-Nov-2024

    Summary

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    Official Symbol
    GCD2
    Official Full Name
    translation initiation factor eIF2B subunit delta
    Primary source
    SGD:S000003315
    Locus tag
    YGR083C
    See related
    AllianceGenome:SGD:S000003315; FungiDB:YGR083C; VEuPathDB:YGR083C
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Also known as
    GCD12
    Summary
    Enables enzyme regulator activity and translation initiation factor activity. Contributes to guanyl-nucleotide exchange factor activity. Involved in regulation of translational initiation. Located in cytosol. Part of eukaryotic translation initiation factor 2B complex and guanyl-nucleotide exchange factor complex. Used to study leukoencephalopathy with vanishing white matter. Human ortholog(s) of this gene implicated in leukoencephalopathy with vanishing white matter and leukoencephalopathy with vanishing white matter 4. Orthologous to human EIF2B4 (eukaryotic translation initiation factor 2B subunit delta). [provided by Alliance of Genome Resources, Nov 2024]
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    Genomic context

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    See GCD2 in Genome Data Viewer
    Location:
    chromosome: VII
    Exon count:
    1
    Sequence:
    Chromosome: VII; NC_001139.9 (644860..646815, complement)

    Chromosome VII - NC_001139.9Genomic Context describing neighboring genes Neighboring gene Slx9p Neighboring gene Tom20p Neighboring gene mitochondrial 37S ribosomal protein YmS-A Neighboring gene ribosomal 60S subunit protein L11B

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001139.9

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. gcd12 mutations are gcn3-dependent alleles of GCD2, a negative regulator of GCN4 in the general amino acid control of Saccharomyces cerevisiae. Paddon CJ, et al. Genetics, 1989 Jul. PMID 2668116, Free PMC Article
    2. A segment of GCN4 mRNA containing the upstream AUG codons confers translational control upon a heterologous yeast transcript. Mueller PP, et al. Proc Natl Acad Sci U S A, 1987 May. PMID 3554249, Free PMC Article
    3. GCD2, a translational repressor of the GCN4 gene, has a general function in the initiation of protein synthesis in Saccharomyces cerevisiae. Foiani M, et al. Mol Cell Biol, 1991 Jun. PMID 2038326, Free PMC Article
    4. Amino acid sequence similarity between GCN3 and GCD2, positive and negative translational regulators of GCN4: evidence for antagonism by competition. Paddon CJ, et al. Genetics, 1989 Jul. PMID 2668117, Free PMC Article
    5. Molecular analysis of GCN3, a translational activator of GCN4: evidence for posttranslational control of GCN3 regulatory function. Hannig EM, et al. Mol Cell Biol, 1988 Nov. PMID 3062370, Free PMC Article

    See all (68) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables enzyme regulator activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables enzyme regulator activity IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    enables enzyme regulator activity IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    contributes_to guanyl-nucleotide exchange factor activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables translation initiation factor activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables translation initiation factor activity IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    enables translation initiation factor activity IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in regulation of translation IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in regulation of translational initiation IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in regulation of translational initiation IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in regulation of translational initiation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in regulation of translational initiation IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    involved_in translation IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in translational initiation IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytosol HDA PubMed 
    located_in cytosol IEA
    Inferred from Electronic Annotation
    more info
    		  
    part_of eukaryotic translation initiation factor 2B complex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    part_of eukaryotic translation initiation factor 2B complex IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    part_of eukaryotic translation initiation factor 2B complex IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    part_of guanyl-nucleotide exchange factor complex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    part_of guanyl-nucleotide exchange factor complex IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    translation initiation factor eIF2B subunit delta
    NP_011597.1
    • Delta subunit of the translation initiation factor eIF2B; the guanine-nucleotide exchange factor for eIF2; activity subsequently regulated by phosphorylated eIF2; first identified as a negative regulator of GCN4 expression

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001139.9 Reference assembly

      Range
      644860..646815 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001181212.1 → NP_011597.1  TPA: translation initiation factor eIF2B subunit delta [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_011597.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D6VUL5, P12754
      UniProtKB/TrEMBL
      B3LIE3, B5VJ27, C8Z8X7, N1P3Y3
      Conserved Domains (2) summary
      PHA03255
      Location:120 → 232
      PHA03255; BDLF3; Provisional
      pfam01008
      Location:285 → 637
      IF-2B; Initiation factor 2 subunit family
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P12754.1

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