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    vgl1 vigilin [ Schizosaccharomyces pombe (fission yeast) ]

    Gene ID: 2539425, updated on 18-Sep-2024

    Summary

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    Official Symbol
    vgl1
    Official Full Name
    vigilin
    Primary source
    PomBase:SPCC550.14
    Locus tag
    SPOM_SPCC550.14
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Schizosaccharomyces pombe (strain: 972h-)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Taphrinomycotina; Schizosaccharomycetes; Schizosaccharomycetales; Schizosaccharomycetaceae; Schizosaccharomyces
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    Genomic context

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    See vgl1 in Genome Data Viewer
    Location:
    chromosome: III
    Exon count:
    1
    Sequence:
    Chromosome: III; NC_003421.2 (1216873..1221449)

    Chromosome III - NC_003421.2Genomic Context describing neighboring genes Neighboring gene ncRNA Neighboring gene Swr1 actin-like protein Arp6 Neighboring gene Hsk1-Dfp1 kinase complex regulatory subunit Dfp1 Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ribosome biogenesis protein

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003421.2

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Vigilin protein Vgl1 is required for heterochromatin-mediated gene silencing in Schizosaccharomyces pombe. Farooq Z, et al. J Biol Chem, 2019 Nov 29. PMID 31554660, Free PMC Article
    2. The stress granule protein Vgl1 and poly(A)-binding protein Pab1 are required for doxorubicin resistance in the fission yeast Schizosaccharomyces pombe. Morita T, et al. Biochem Biophys Res Commun, 2012 Jan 6. PMID 22172946
    3. Vgl1, a multi-KH domain protein, is a novel component of the fission yeast stress granules required for cell survival under thermal stress. Wen WL, et al. Nucleic Acids Res, 2010 Oct. PMID 20547592, Free PMC Article
    4. Drosophila vigilin, DDP1, localises to the cytoplasm and associates to the rough endoplasmic reticulum. Batlle M, et al. Biochim Biophys Acta, 2011 Jan. PMID 21035573
    5. Enhancer of Rudimentary Cooperates with Conserved RNA-Processing Factors to Promote Meiotic mRNA Decay and Facultative Heterochromatin Assembly. Sugiyama T, et al. Mol Cell, 2016 Mar 3. PMID 26942678, Free PMC Article

    See all (15) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. These findings uncover a novel role for Vgl1 as a key regulator in heterochromatin-mediated gene silencing in S. pombe.
      Title: Vigilin protein Vgl1 is required for heterochromatin-mediated gene silencing in Schizosaccharomyces pombe.
    2. Under thermal stress, Vgl1 is rapidly relocalized from the ER to cytoplasmic foci that are distinct from P-bodies but contain stress granule markers (Vgl1).
      Title: Vgl1, a multi-KH domain protein, is a novel component of the fission yeast stress granules required for cell survival under thermal stress.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by PomBase

    Function Evidence Code Pubs
    enables mRNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in intracellular mRNA localization ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in regulation of mRNA stability NAS
    Non-traceable Author Statement
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in cytoplasm IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in cytoplasmic stress granule EXP
    Inferred from Experiment
    more info
    		 PubMed 
    is_active_in cytoplasmic stress granule IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in cytosol HDA PubMed 
    is_active_in endoplasmic reticulum IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    vigilin

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003421.2 Reference assembly

      Range
      1216873..1221449
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001023097.3 → NP_588106.2  vigilin [Schizosaccharomyces pombe]

      See identical proteins and their annotated locations for NP_588106.2

      Status: PROVISIONAL

      UniProtKB/Swiss-Prot
      O59810
      Conserved Domains (5) summary
      smart00322
      Location:741 → 802
      KH; K homology RNA-binding domain
      cd00105
      Location:1052 → 1115
      KH-I; K homology RNA-binding domain, type I. KH binds single-stranded RNA or DNA. It is found in a wide variety of proteins including ribosomal proteins, transcription factors and post-transcriptional modifiers of mRNA. There are two different KH domains that ...
      cd02394
      Location:810 → 884
      vigilin_like_KH; K homology RNA-binding domain_vigilin_like. The vigilin family is a large and extended family of multiple KH-domain proteins, including vigilin, also called high density lipoprotein binding protien (HBP), fungal Scp160 and bicaudal-C. Yeast Scp160p has ...
      pfam00013
      Location:896 → 957
      KH_1; KH domain
      cl00098
      Location:345 → 406
      KH-I; K homology RNA-binding domain, type I. KH binds single-stranded RNA or DNA. It is found in a wide variety of proteins including ribosomal proteins, transcription factors and post-transcriptional modifiers of mRNA. There are two different KH domains that ...
    Nucleotide Protein
    Heading Accession and Version

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