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    SNO4 glutathione-independent methylglyoxalase family protein [ Saccharomyces cerevisiae S288C ]

    Gene ID: 855372, updated on 17-May-2024

    Summary

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    Gene symbol
    SNO4
    Gene description
    glutathione-independent methylglyoxalase family protein
    Primary source
    FungiDB:YMR322C
    Locus tag
    YMR322C
    See related
    SGD:S000004941; AllianceGenome:SGD:S000004941; VEuPathDB:YMR322C
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Also known as
    HSP34
    Summary
    Enables glyoxalase III activity. Involved in cellular response to nutrient levels. Predicted to be located in P-body. Used to study Parkinson's disease and cancer. [provided by Alliance of Genome Resources, Apr 2022]
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    Genomic context

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    See SNO4 in Genome Data Viewer
    Location:
    chromosome: XIII
    Exon count:
    1
    Sequence:
    Chromosome: XIII; NC_001145.3 (918366..919079, complement)

    Chromosome XIII - NC_001145.3Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene phosphopyruvate hydratase ERR3 Neighboring gene seripauperin PAU19

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001145.3

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Saccharomyces cerevisiae Hsp31p, a stress response protein conferring protection against reactive oxygen species. Skoneczna A, et al. Free Radic Biol Med, 2007 May 1. PMID 17395014
    2. Redox-dependent regulation of mitochondrial dynamics by DJ-1 paralogs in Saccharomyces cerevisiae. Bankapalli K, et al. Redox Biol, 2020 May. PMID 32070881, Free PMC Article
    3. Robust glyoxalase activity of Hsp31, a ThiJ/DJ-1/PfpI family member protein, is critical for oxidative stress resistance in Saccharomyces cerevisiae. Bankapalli K, et al. J Biol Chem, 2015 Oct 30. PMID 26370081, Free PMC Article
    4. Yeast DJ-1 superfamily members are required for diauxic-shift reprogramming and cell survival in stationary phase. Miller-Fleming L, et al. Proc Natl Acad Sci U S A, 2014 May 13. PMID 24706893, Free PMC Article
    5. The 1.8-A resolution crystal structure of YDR533Cp from Saccharomyces cerevisiae: a member of the DJ-1/ThiJ/PfpI superfamily. Wilson MA, et al. Proc Natl Acad Sci U S A, 2004 Feb 10. PMID 14745011, Free PMC Article

    See all (24) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. protects the cell against oxidative stress and complements other stress protection systems within the cell
      Title: Saccharomyces cerevisiae Hsp31p, a stress response protein conferring protection against reactive oxygen species.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables glyoxalase III activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables glyoxalase III activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables glyoxalase III activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables glyoxalase III activity IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    enables lyase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in cellular response to nutrient levels IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in lactate biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in methylglyoxal catabolic process to D-lactate via S-lactoyl-glutathione IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    located_in P-body IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in cellular_component ND
    No biological Data available
    more info
    		  
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    glutathione-independent methylglyoxalase family protein
    NP_014055.1
    • Possible chaperone and cysteine protease; required for transcriptional reprogramming during the diauxic shift and for survival in stationary phase; similar to bacterial Hsp31 and yeast Hsp31p, Hsp32p, and Hsp33p; DJ-1/ThiJ/PfpI superfamily member; predicted involvement in pyridoxine metabolism; induced by mild heat stress and copper deprivation

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001145.3 Reference assembly

      Range
      918366..919079 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001182835.1 → NP_014055.1  TPA: glutathione-independent methylglyoxalase family protein [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_014055.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D6W0E9, Q04902
      UniProtKB/TrEMBL
      A0A8H4BZ39, G2WNQ1
      Conserved Domains (1) summary
      cl00020
      Location:5 → 235
      GAT_1; Type 1 glutamine amidotransferase (GATase1)-like domain
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q04902.1

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