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    ubp6 ubiquitin hydrolase Ubp6 [ Schizosaccharomyces pombe (fission yeast) ]

    Gene ID: 2541819, updated on 22-Jun-2024

    Summary

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    Gene symbol
    ubp6
    Gene description
    ubiquitin hydrolase Ubp6
    Locus tag
    SPOM_SPAC6G9.08
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Schizosaccharomyces pombe (strain: 972h-)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Taphrinomycotina; Schizosaccharomycetes; Schizosaccharomycetales; Schizosaccharomycetaceae; Schizosaccharomyces
    Old locus tag
    SPAC6G9.08
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    Genomic context

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    See ubp6 in Genome Data Viewer
    Location:
    chromosome: I
    Exon count:
    1
    Sequence:
    Chromosome: I; NC_003424.3 (3259605..3262222)

    Chromosome I - NC_003424.3Genomic Context describing neighboring genes Neighboring gene ncRNA Neighboring gene gamma tubulin complex linker, pericentrin/kendrin Pcp1 Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ARP2/3 actin-organizing complex subunit Arc4 Neighboring gene ncRNA Neighboring gene 60S ribosomal protein eL24 Neighboring gene helicase Sen1 Neighboring gene ncRNA

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003424.3

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Uch2/Uch37 is the major deubiquitinating enzyme associated with the 26S proteasome in fission yeast. Stone M, et al. J Mol Biol, 2004 Nov 26. PMID 15533439
    2. Widespread cotranslational formation of protein complexes. Duncan CD, et al. PLoS Genet, 2011 Dec. PMID 22144913, Free PMC Article
    3. A global census of fission yeast deubiquitinating enzyme localization and interaction networks reveals distinct compartmentalization profiles and overlapping functions in endocytosis and polarity. Kouranti I, et al. PLoS Biol, 2010 Sep 7. PMID 20838651, Free PMC Article
    4. Systematic screen for mutants resistant to TORC1 inhibition in fission yeast reveals genes involved in cellular ageing and growth. Rallis C, et al. Biol Open, 2014 Feb 15. PMID 24463365, Free PMC Article
    5. Expanded Interactome of the Intrinsically Disordered Protein Dss1. Schenstrøm SM, et al. Cell Rep, 2018 Oct 23. PMID 30355493, Free PMC Article

    See all (11) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by PomBase

    Function Evidence Code Pubs
    enables cysteine-type deubiquitinase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables metal-dependent deubiquitinase activity HDA PubMed 
    enables proteasome binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in proteasome-mediated ubiquitin-dependent protein catabolic process IC
    Inferred by Curator
    more info
    		  
    involved_in protein deubiquitination IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in regulation of proteasomal protein catabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    NOT is_active_in nucleolus HDA PubMed 
    is_active_in nucleoplasm HDA PubMed 
    is_active_in nucleus HDA PubMed 

    General protein information

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    Preferred Names
    ubiquitin hydrolase Ubp6

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003424.3 Reference assembly

      Range
      3259605..3262222
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001019541.3 → NP_594117.2  ubiquitin hydrolase Ubp6 [Schizosaccharomyces pombe]

      See identical proteins and their annotated locations for NP_594117.2

      Status: PROVISIONAL

      UniProtKB/Swiss-Prot
      Q92353
      Conserved Domains (4) summary
      smart00213
      Location:3 → 73
      UBQ; Ubiquitin homologues
      cd02657
      Location:102 → 463
      Peptidase_C19A; A subfamily of Peptidase C19. Peptidase C19 contains ubiquitinyl hydrolases. They are intracellular peptidases that remove ubiquitin molecules from polyubiquinated peptides by cleavage of isopeptide bonds. They hydrolyse bonds involving the carboxyl ...
      pfam00240
      Location:10 → 72
      ubiquitin; Ubiquitin family
      pfam00443
      Location:100 → 462
      UCH; Ubiquitin carboxyl-terminal hydrolase
    Nucleotide Protein
    Heading Accession and Version

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