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    BCP1 protein-transporting protein BCP1 [ Saccharomyces cerevisiae S288C ]

    Gene ID: 851963, updated on 2-Nov-2024

    Summary

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    Official Symbol
    BCP1
    Official Full Name
    protein-transporting protein BCP1
    Primary source
    SGD:S000002769
    Locus tag
    YDR361C
    See related
    AllianceGenome:SGD:S000002769; FungiDB:YDR361C; VEuPathDB:YDR361C
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Summary
    Enables protein folding chaperone. Involved in protein export from nucleus and ribosomal large subunit export from nucleus. Located in cytoplasm and nucleus. Orthologous to human BCCIP (BRCA2 and CDKN1A interacting protein). [provided by Alliance of Genome Resources, Nov 2024]
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    Genomic context

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    See BCP1 in Genome Data Viewer
    Location:
    chromosome: IV
    Exon count:
    1
    Sequence:
    Chromosome: IV; NC_001136.10 (1195412..1196263, complement)

    Chromosome IV - NC_001136.10Genomic Context describing neighboring genes Neighboring gene ubiquitin-binding protein Neighboring gene Eaf1p Neighboring gene transcription factor TFIIIC subunit TFC6 Neighboring gene Esc2p

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001136.10

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Regulation of PI4,5P2 synthesis by nuclear-cytoplasmic shuttling of the Mss4 lipid kinase. Audhya A, et al. EMBO J, 2003 Aug 15. PMID 12912920, Free PMC Article
    2. The crystal structure of protein-transporting chaperone BCP1 from Saccharomyces cerevisiae. Lin MH, et al. J Struct Biol, 2020 Oct 1. PMID 32805410
    3. Dual protection by Bcp1 and Rkm1 ensures incorporation of uL14 into pre-60S ribosomal subunits. Yeh MC, et al. J Cell Biol, 2024 Aug 5. PMID 39007857, Free PMC Article
    4. Bcp1 Is the Nuclear Chaperone of Rpl23 in Saccharomyces cerevisiae. Ting YH, et al. J Biol Chem, 2017 Jan 13. PMID 27913624, Free PMC Article
    5. Combining chemical genetics and proteomics to identify protein kinase substrates. Dephoure N, et al. Proc Natl Acad Sci U S A, 2005 Dec 13. PMID 16330754, Free PMC Article

    See all (40) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables protein folding chaperone IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in protein export from nucleus IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in protein folding IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in protein transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in ribosomal large subunit export from nucleus IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in cytoplasm HDA PubMed 
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in nucleus HDA PubMed 
    located_in nucleus HDA PubMed 
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    protein-transporting protein BCP1
    NP_010648.3
    • Essential nuclear chaperone for ribosomal protein Rpl23p; involved in nuclear export of Mss4p; Mss4p is a lipid kinase that generates phosphatidylinositol 4,5-biphosphate and plays a role in actin cytoskeleton organization and vesicular transport

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001136.10 Reference assembly

      Range
      1195412..1196263 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001180669.3 → NP_010648.3  TPA: protein-transporting protein BCP1 [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_010648.3

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D6VSY9, Q06338
      UniProtKB/TrEMBL
      A6ZYV9, B3LFU2, B5VGP2, C7GMH6, C8Z5S3, G2WB97, N1P8Q3
      Conserved Domains (1) summary
      pfam13862
      Location:48 → 241
      BCIP; p21-C-terminal region-binding protein
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q06338.1

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