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    MUD2 Mud2p [ Saccharomyces cerevisiae S288C ]

    Gene ID: 853788, updated on 2-Nov-2024

    Summary

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    Official Symbol
    MUD2
    Official Full Name
    Mud2p
    Primary source
    SGD:S000001557
    Locus tag
    YKL074C
    See related
    AllianceGenome:SGD:S000001557; FungiDB:YKL074C; VEuPathDB:YKL074C
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Summary
    Enables pre-mRNA branch point binding activity. Involved in mRNA branch site recognition. Part of commitment complex. Human ortholog(s) of this gene implicated in developmental delay, dysmorphic facies, and brain anomalies. Orthologous to human U2AF2 (U2 small nuclear RNA auxiliary factor 2). [provided by Alliance of Genome Resources, Nov 2024]
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    Genomic context

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    See MUD2 in Genome Data Viewer
    Location:
    chromosome: XI
    Exon count:
    1
    Sequence:
    Chromosome: XI; NC_001143.9 (294610..296193, complement)

    Chromosome XI - NC_001143.9Genomic Context describing neighboring genes Neighboring gene Psg1p Neighboring gene Aan1p Neighboring gene Hsp70 family chaperone LHS1 Neighboring gene Stb6p

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001143.9

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. In vivo commitment to splicing in yeast involves the nucleotide upstream from the branch site conserved sequence and the Mud2 protein. Rain JC, et al. EMBO J, 1997 Apr 1. PMID 9130720, Free PMC Article
    2. Conservation of functional domains involved in RNA binding and protein-protein interactions in human and Saccharomyces cerevisiae pre-mRNA splicing factor SF1. Rain JC, et al. RNA, 1998 May. PMID 9582097, Free PMC Article
    3. The yeast MUD2 protein: an interaction with PRP11 defines a bridge between commitment complexes and U2 snRNP addition. Abovich N, et al. Genes Dev, 1994 Apr 1. PMID 7926772
    4. Characterization of a mimivirus RNA cap guanine-N2 methyltransferase. Benarroch D, et al. RNA, 2009 Apr. PMID 19218551, Free PMC Article
    5. Deletion of MUD2, the yeast homolog of U2AF65, can bypass the requirement for sub2, an essential spliceosomal ATPase. Kistler AL, et al. Genes Dev, 2001 Jan 1. PMID 11156604, Free PMC Article

    See all (95) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Mud2 is a novel transcription factor that is necessary for the recruitment of mRNA-binding proteins to the transcription machinery. Thus, Mud2 is a multifunctional protein important for transcription, splicing and most likely also mRNP packaging.
      Title: Mud2 functions in transcription by recruiting the Prp19 and TREX complexes to transcribed genes.
    2. BBP/Mud2 influences U1 binding at the 5' splice site by promoting long-lived E complex formation.
      Title: Dynamics and consequences of spliceosome E complex formation.
    3. exploited the synthetic lethal interactions of tgs1Delta and mud2Delta mutations to identify essential structural features of the Tgs1 and Mud2 proteins
      Title: Mutational analyses of trimethylguanosine synthase (Tgs1) and Mud2: proteins implicated in pre-mRNA splicing.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables RNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables mRNA binding HDA PubMed 
    enables nucleic acid binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables poly-pyrimidine tract binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables pre-mRNA 3'-splice site binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables pre-mRNA branch point binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in RNA splicing IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in mRNA branch site recognition IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in mRNA branch site recognition IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in mRNA processing IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in spliceosomal complex assembly IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    part_of U2-type prespliceosome IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of U2AF complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of commitment complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of commitment complex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    part_of commitment complex IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    is_active_in nuclear speck IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    Mud2p
    NP_012849.1
    • Protein involved in early pre-mRNA splicing; component of the pre-mRNA-U1 snRNP complex, the commitment complex; interacts with Msl5p/BBP splicing factor and Sub2p; similar to metazoan splicing factor U2AF65

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001143.9 Reference assembly

      Range
      294610..296193 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001179640.1 → NP_012849.1  TPA: Mud2p [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_012849.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D6VXL2, P36084
      UniProtKB/TrEMBL
      B3LR16, B5VM81, C7GVN3, N1NZ64
      Conserved Domains (2) summary
      smart00361
      Location:436 → 511
      RRM_1; RNA recognition motif
      PRK12678
      Location:46 → 156
      PRK12678; transcription termination factor Rho; Provisional
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P36084.3

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