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    GRX8 glutathione-disulfide reductase GRX8 [ Saccharomyces cerevisiae S288C ]

    Gene ID: 851079, updated on 17-May-2024

    Summary

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    Gene symbol
    GRX8
    Gene description
    glutathione-disulfide reductase GRX8
    Primary source
    FungiDB:YLR364W
    Locus tag
    YLR364W
    See related
    SGD:S000004356; AllianceGenome:SGD:S000004356; VEuPathDB:YLR364W
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Summary
    Enables glutathione-disulfide reductase (NADPH) activity. Predicted to be involved in cellular oxidant detoxification. Located in cytoplasm. [provided by Alliance of Genome Resources, Apr 2022]
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    Genomic context

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    See GRX8 in Genome Data Viewer
    Location:
    chromosome: XII
    Exon count:
    1
    Sequence:
    Chromosome: XII; NC_001144.5 (854062..854391)

    Chromosome XII - NC_001144.5Genomic Context describing neighboring genes Neighboring gene Nmd4p Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene ribosomal 40S subunit protein S22B Neighboring gene ncRNA

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001144.5

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Structure-guided activity enhancement and catalytic mechanism of yeast grx8. Tang Y, et al. Biochemistry, 2014 Apr 8. PMID 24611845
    2. Two novel monothiol glutaredoxins from Saccharomyces cerevisiae provide further insight into iron-sulfur cluster binding, oligomerization, and enzymatic activity of glutaredoxins. Mesecke N, et al. Biochemistry, 2008 Feb 5. PMID 18171082
    3. Biochemical characterization of dithiol glutaredoxin 8 from Saccharomyces cerevisiae: the catalytic redox mechanism redux. Eckers E, et al. Biochemistry, 2009 Feb 17. PMID 19166312
    4. Integrating phenotypic and expression profiles to map arsenic-response networks. Haugen AC, et al. Genome Biol, 2004. PMID 15575969, Free PMC Article
    5. αβ'-NAC cooperates with Sam37 to mediate early stages of mitochondrial protein import. Ponce-Rojas JC, et al. FEBS J, 2017 Mar. PMID 28109174

    See all (16) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. catalytic mechanism of yeast grx8
      Title: Structure-guided activity enhancement and catalytic mechanism of yeast grx8.
    2. ScGrx8 has several novel structural and mechanistic features expanding the subclasses of glutaredoxins.
      Title: Biochemical characterization of dithiol glutaredoxin 8 from Saccharomyces cerevisiae: the catalytic redox mechanism redux.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables glutathione-disulfide reductase (NADPH) activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables oxidoreductase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in biological_process ND
    No biological Data available
    more info
    		  
    involved_in cellular oxidant detoxification IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in cytoplasm HDA PubMed 
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    glutathione-disulfide reductase GRX8
    NP_013468.3
    • Glutaredoxin that employs a dithiol mechanism of catalysis; monomeric; activity is low and null mutation does not affect sensitivity to oxidative stress; GFP-fusion protein localizes to the cytoplasm; expression strongly induced by arsenic

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001144.5 Reference assembly

      Range
      854062..854391
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001182253.3 → NP_013468.3  TPA: glutathione-disulfide reductase GRX8 [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_013468.3

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D6VZ03, Q05926
      UniProtKB/TrEMBL
      A0A6A5PV73, A7A1P3, B3RHN3, C7GRW0, C8ZDX3, G2WJI3, N1P791
      Conserved Domains (1) summary
      COG0695
      Location:21 → 99
      GrxC; Glutaredoxin [Posttranslational modification, protein turnover, chaperones]
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q05926.1

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