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    TRM5 tRNA (guanine) methyltransferase [ Saccharomyces cerevisiae S288C ]

    Gene ID: 856467, updated on 17-May-2024

    Summary

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    Gene symbol
    TRM5
    Gene description
    tRNA (guanine) methyltransferase
    Primary source
    FungiDB:YHR070W
    Locus tag
    YHR070W
    See related
    SGD:S000001112; AllianceGenome:SGD:S000001112; VEuPathDB:YHR070W
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Summary
    Enables tRNA (guanine-N1-)-methyltransferase activity. Involved in mitochondrial tRNA methylation and tRNA N1-guanine methylation. Located in mitochondrial matrix. Used to study several diseases, including cytochrome-c oxidase deficiency disease; hypercalcemia; lactic acidosis; mitochondrial complex III deficiency; and mitochondrial myopathy. Human ortholog(s) of this gene implicated in combined oxidative phosphorylation deficiency 26. Orthologous to human TRMT5 (tRNA methyltransferase 5). [provided by Alliance of Genome Resources, Apr 2022]
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    Genomic context

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    See TRM5 in Genome Data Viewer
    Location:
    chromosome: VIII
    Exon count:
    1
    Sequence:
    Chromosome: VIII; NC_001140.6 (234881..236380)

    Chromosome VIII - NC_001140.6Genomic Context describing neighboring genes Neighboring gene deoxyhypusine synthase Neighboring gene exosome non-catalytic core subunit RRP4 Neighboring gene Pcl5p Neighboring gene tRNA-Phe

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001140.6

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Yeast mitochondrial initiator tRNA is methylated at guanosine 37 by the Trm5-encoded tRNA (guanine-N1-)-methyltransferase. Lee C, et al. J Biol Chem, 2007 Sep 21. PMID 17652090
    2. A primordial tRNA modification required for the evolution of life? Björk GR, et al. EMBO J, 2001 Jan 15. PMID 11226173, Free PMC Article
    3. Retrograde nuclear import of tRNA precursors is required for modified base biogenesis in yeast. Ohira T, et al. Proc Natl Acad Sci U S A, 2011 Jun 28. PMID 21670254, Free PMC Article
    4. TRMT5 Mutations Cause a Defect in Post-transcriptional Modification of Mitochondrial tRNA Associated with Multiple Respiratory-Chain Deficiencies. Powell CA, et al. Am J Hum Genet, 2015 Aug 6. PMID 26189817, Free PMC Article
    5. Detection and discovery of RNA modifications using microarrays. Hiley SL, et al. Nucleic Acids Res, 2005 Jan 7. PMID 15640439, Free PMC Article

    See all (24) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. mitochondrial initiator tRNA is methylated at guanosine 37 by the Trm5-encoded tRNA (guanine-N1-)-methyltransferase
      Title: Yeast mitochondrial initiator tRNA is methylated at guanosine 37 by the Trm5-encoded tRNA (guanine-N1-)-methyltransferase.
    Submit: New GeneRIF Correction

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables methyltransferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables tRNA (guanine(37)-N1)-methyltransferase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables tRNA (guanine(37)-N1)-methyltransferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables tRNA (guanine(37)-N1)-methyltransferase activity IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    enables tRNA methyltransferase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in methylation IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in mitochondrial tRNA methylation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in mitochondrial tRNA methylation IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in tRNA N1-guanine methylation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in tRNA N1-guanine methylation IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in tRNA N1-guanine methylation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in tRNA methylation IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in tRNA processing IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in cytoplasm HDA PubMed 
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytoplasm IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in mitochondrial matrix IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in mitochondrial matrix IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in mitochondrial matrix IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in mitochondrion IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nucleus HDA PubMed 
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    tRNA (guanine) methyltransferase
    NP_011937.1
    • tRNA(m(1)G37)methyltransferase; methylates a tRNA base adjacent to the anticodon that has a role in prevention of frameshifting; localized to both cytoplasm and mitochondria, and modifies both cytoplasmic and mitochondrial tRNAs; mutations in human ortholog TRMT5 are associated with skeletal muscle respiratory chain deficiencies, and trm5 mutations analogous to disease mutations decrease respiration

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001140.6 Reference assembly

      Range
      234881..236380
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001179200.1 → NP_011937.1  TPA: tRNA (guanine) methyltransferase [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_011937.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D3DL19, P38793
      UniProtKB/TrEMBL
      A0A8H4FCN9, A6ZSX6, B3LSI8, C7GWT1, C8Z9K9, G2WFE2
      Conserved Domains (1) summary
      COG2520
      Location:75 → 459
      Trm5; tRNA G37 N-methylase Trm5 [Translation, ribosomal structure and biogenesis]
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P38793.1

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