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    BMT5 25S rRNA (uracil2634-N3)-methyltransferase [ Saccharomyces cerevisiae S288C ]

    Gene ID: 854711, updated on 17-May-2024

    Summary

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    Gene symbol
    BMT5
    Gene description
    25S rRNA (uracil2634-N3)-methyltransferase
    Primary source
    FungiDB:YIL096C
    Locus tag
    YIL096C
    See related
    SGD:S000001358; AllianceGenome:SGD:S000001358
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Summary
    Enables rRNA (uridine-N3-)-methyltransferase activity. Involved in rRNA base methylation. Located in nucleolus. Orthologous to human FDXACB1 (ferredoxin-fold anticodon binding domain containing 1). [provided by Alliance of Genome Resources, Apr 2022]
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    Genomic context

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    See BMT5 in Genome Data Viewer
    Location:
    chromosome: IX
    Exon count:
    1
    Sequence:
    Chromosome: IX; NC_001141.2 (182117..183127, complement)

    Chromosome IX - NC_001141.2Genomic Context describing neighboring genes Neighboring gene Fmc1p Neighboring gene glucose-induced degradation complex subunit FYV10 Neighboring gene tRNA-Ile Neighboring gene serine/threonine protein kinase PRK1

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001141.2

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Identification of novel methyltransferases, Bmt5 and Bmt6, responsible for the m3U methylations of 25S rRNA in Saccharomyces cerevisiae. Sharma S, et al. Nucleic Acids Res, 2014 Mar. PMID 24335083, Free PMC Article
    2. Probabilistic approach to predicting substrate specificity of methyltransferases. Szczepińska T, et al. PLoS Comput Biol, 2014 Mar. PMID 24651469, Free PMC Article
    3. Comprehensive structural and substrate specificity classification of the Saccharomyces cerevisiae methyltransferome. Wlodarski T, et al. PLoS One, 2011. PMID 21858014, Free PMC Article
    4. The budding yeast rRNA and ribosome biosynthesis (RRB) regulon contains over 200 genes. Wade CH, et al. Yeast, 2006 Mar. PMID 16544271
    5. The interplay between chromosome stability and cell cycle control explored through gene-gene interaction and computational simulation. Frumkin JP, et al. Nucleic Acids Res, 2016 Sep 30. PMID 27530428, Free PMC Article

    See all (26) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Identification of BMT5 (YIL096C)as being responsible for m3U2634 methylation of the 25S rRNA.
      Title: Identification of novel methyltransferases, Bmt5 and Bmt6, responsible for the m3U methylations of 25S rRNA in Saccharomyces cerevisiae.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables S-adenosylmethionine-dependent methyltransferase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables methyltransferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables rRNA (uridine-N3-)-methyltransferase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables rRNA (uridine-N3-)-methyltransferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables rRNA (uridine-N3-)-methyltransferase activity IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in methylation IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in rRNA base methylation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in rRNA base methylation IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in rRNA base methylation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in rRNA processing IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleolus HDA PubMed 
    located_in nucleolus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in nucleolus IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nucleus HDA PubMed 
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    25S rRNA (uracil2634-N3)-methyltransferase
    NP_012170.1
    • Methyltransferase required for m3U2634 methylation of the 25S rRNA; S-adenosylmethionine-dependent; associates with precursors of the 60S ribosomal subunit; predicted to be involved in ribosome biogenesis

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001141.2 Reference assembly

      Range
      182117..183127 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001179444.1 → NP_012170.1  TPA: 25S rRNA (uracil2634-N3)-methyltransferase [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_012170.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D6VVJ1, P40493
      UniProtKB/TrEMBL
      A0A8H4BZ40, A6ZVI1, B3LTU3, C7GKM3, G2WG56, N1P0X5
      Conserved Domains (1) summary
      pfam10354
      Location:76 → 292
      DUF2431; Domain of unknown function (DUF2431)
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P40493.1

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