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    pcf11 cleavage and polyadenylation specificity factor [ Schizosaccharomyces pombe (fission yeast) ]

    Gene ID: 2543037, updated on 22-Jun-2024

    Summary

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    Gene symbol
    pcf11
    Gene description
    cleavage and polyadenylation specificity factor
    Locus tag
    SPOM_SPAC4G9.04C
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Schizosaccharomyces pombe (strain: 972h-)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Taphrinomycotina; Schizosaccharomycetes; Schizosaccharomycetales; Schizosaccharomycetaceae; Schizosaccharomyces
    Old locus tag
    SPAC4G9.04c
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    Genomic context

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    See pcf11 in Genome Data Viewer
    Location:
    chromosome: I
    Exon count:
    2
    Sequence:
    Chromosome: I; NC_003424.3 (2255677..2259186, complement)

    Chromosome I - NC_003424.3Genomic Context describing neighboring genes Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene tubulin-specific chaperone cofactor B Neighboring gene ribonuclease H2 complex subunit Rnh201 Neighboring gene ncRNA Neighboring gene adenylate kinase Adk1 Neighboring gene histone chaperone Chz1 Neighboring gene meiotic PUF family protein 1 Neighboring gene ncRNA Neighboring gene protein Mug133

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003424.3

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Structure of Ctk3, a subunit of the RNA polymerase II CTD kinase complex, reveals a noncanonical CTD-interacting domain fold. Mühlbacher W, et al. Proteins, 2015 Oct. PMID 26219431
    2. Polyadenylation site selection: linking transcription and RNA processing via a conserved carboxy-terminal domain (CTD)-interacting protein. Larochelle M, et al. Curr Genet, 2017 May. PMID 27582274
    3. Rhn1, a nuclear protein, is required for suppression of meiotic mRNAs in mitotically dividing fission yeast. Sugiyama T, et al. PLoS One, 2012. PMID 22912768, Free PMC Article
    4. Chromosome-associated RNA-protein complexes promote pairing of homologous chromosomes during meiosis in Schizosaccharomyces pombe. Ding DQ, et al. Nat Commun, 2019 Dec 6. PMID 31811152, Free PMC Article
    5. The conserved protein Seb1 drives transcription termination by binding RNA polymerase II and nascent RNA. Wittmann S, et al. Nat Commun, 2017 Apr 3. PMID 28367989, Free PMC Article

    See all (11) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by PomBase

    Function Evidence Code Pubs
    enables RNA polymerase II C-terminal domain binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables RNA polymerase II complex binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables mRNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables mRNA binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in co-transcriptional mRNA 3'-end processing, cleavage and polyadenylation pathway IC
    Inferred by Curator
    more info
    		  
    involved_in termination of RNA polymerase II transcription IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in termination of RNA polymerase II transcription ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    part_of Mei2 nuclear dot complex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    part_of chromatin IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of mRNA cleavage factor complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of mRNA cleavage stimulating factor complex ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in nucleus HDA PubMed 
    is_active_in nucleus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    cleavage and polyadenylation specificity factor

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003424.3 Reference assembly

      Range
      2255677..2259186 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001019118.3 → NP_593686.1  cleavage and polyadenylation specificity factor [Schizosaccharomyces pombe]

      See identical proteins and their annotated locations for NP_593686.1

      Status: PROVISIONAL

      UniProtKB/Swiss-Prot
      Q10237
      Conserved Domains (1) summary
      cd03562
      Location:7 → 116
      CID; CID (CTD-Interacting Domain) domain family; CID is present in several RNA-processing factors such as Pcf11 and Nrd1. Pcf11 is a conserved and essential subunit of the yeast cleavage factor IA, which is required for polyadenylation-dependent 3'-RNA ...
    Nucleotide Protein
    Heading Accession and Version

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