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    ATF2 alcohol O-acetyltransferase [ Saccharomyces cerevisiae S288C ]

    Gene ID: 853088, updated on 18-Sep-2024

    Summary

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    Official Symbol
    ATF2
    Official Full Name
    alcohol O-acetyltransferase
    Primary source
    SGD:S000003409
    Locus tag
    YGR177C
    See related
    AllianceGenome:SGD:S000003409; FungiDB:YGR177C; VEuPathDB:YGR177C
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Summary
    Enables alcohol O-acetyltransferase activity. Involved in acetate ester metabolic process involved in fermentation; response to toxic substance; and sterol acetylation. Is integral component of endoplasmic reticulum membrane. [provided by Alliance of Genome Resources, Apr 2022]
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    Genomic context

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    See ATF2 in Genome Data Viewer
    Location:
    chromosome: VII
    Exon count:
    1
    Sequence:
    Chromosome: VII; NC_001139.9 (848829..850436, complement)

    Chromosome VII - NC_001139.9Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene squalene monooxygenase Neighboring gene Pbp1p Neighboring gene Okp1p

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001139.9

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Isolation and characterization of the ATF2 gene encoding alcohol acetyltransferase II in the bottom fermenting yeast Saccharomyces pastorianus. Yoshimoto H, et al. Yeast, 1999 Mar 30. PMID 10219999
    2. Pregnenolone esterification in Saccharomyces cerevisiae. A potential detoxification mechanism. Cauet G, et al. Eur J Biochem, 1999 Apr. PMID 10103065
    3. Cloning and nucleotide sequence of the alcohol acetyltransferase II gene (ATF2) from Saccharomyces cerevisiae Kyokai No. 7. Nagasawa N, et al. Biosci Biotechnol Biochem, 1998 Oct. PMID 9836419
    4. Construction and Analysis of a Yeast for the Simultaneous Release and Esterification of the Varietal Thiol 3-Sulfanylhexan-1-ol. Kiene F, et al. J Agric Food Chem, 2021 Oct 13. PMID 34609136
    5. Impact of the timing and the nature of nitrogen additions on the production kinetics of fermentative aromas by Saccharomyces cerevisiae during winemaking fermentation in synthetic media. Seguinot P, et al. Food Microbiol, 2018 Dec. PMID 30166153

    See all (43) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables N-acetyltransferase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables acyltransferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables alcohol O-acetyltransferase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables alcohol O-acetyltransferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in acetate ester metabolic process involved in fermentation IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in response to toxic substance IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in steroid metabolic process IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in cytoplasm HDA PubMed 
    located_in endoplasmic reticulum HDA PubMed 
    located_in endoplasmic reticulum IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in endoplasmic reticulum membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in endoplasmic reticulum membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in lipid droplet IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    alcohol O-acetyltransferase
    NP_011693.1
    • Alcohol acetyltransferase; may play a role in steroid detoxification; forms volatile esters during fermentation, which is important for brewing and winemaking

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001139.9 Reference assembly

      Range
      848829..850436 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001181306.1 → NP_011693.1  TPA: alcohol O-acetyltransferase [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_011693.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D6VUW1, E9P955, P53296
      UniProtKB/TrEMBL
      A6ZUI9, B3LI53, B5VJC0, C7GT21, C8Z973, N1P2F9
      Conserved Domains (1) summary
      pfam07247
      Location:23 → 529
      AATase; Alcohol acetyltransferase
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P53296.1

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