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    dhp1 5'-3' exoribonuclease Dhp1 [ Schizosaccharomyces pombe (fission yeast) ]

    Gene ID: 2542674, updated on 17-May-2024

    Summary

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    Gene symbol
    dhp1
    Gene description
    5'-3' exoribonuclease Dhp1
    Primary source
    PomBase:SPAC26A3.12c
    Locus tag
    SPAC26A3.12c
    See related
    FungiDB:SPAC26A3.12c; VEuPathDB:SPAC26A3.12c
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Schizosaccharomyces pombe (strain: 972h-)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Taphrinomycotina; Schizosaccharomycetes; Schizosaccharomycetales; Schizosaccharomycetaceae; Schizosaccharomyces
    Also known as
    rat1
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    Genomic context

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    See dhp1 in Genome Data Viewer
    Location:
    chromosome: I
    Exon count:
    1
    Sequence:
    Chromosome: I; NC_003424.3 (3356144..3361083, complement)

    Chromosome I - NC_003424.3Genomic Context describing neighboring genes Neighboring gene 60S ribosomal protein L11 Neighboring gene Sm snRNP core protein Smb1 Neighboring gene putative Rho-type GTPase-activating protein Rga2 Neighboring gene putative centaurin ADOP ribosylation factor GTPase-activating protein Neighboring gene amidohydrolase Neighboring gene retrotransposable element Neighboring gene uncharacterized protein

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003424.3

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Co-transcriptional RNA cleavage by Drosha homolog Pac1 triggers transcription termination in fission yeast. Yague-Sanz C, et al. Nucleic Acids Res, 2021 Sep 7. PMID 34352089, Free PMC Article
    2. Pac1 endonuclease and Dhp1p 5'-->3' exonuclease are required for U3 snoRNA termination in Schizosaccharomyces pombe. Nabavi S, et al. FEBS Lett, 2010 Aug 4. PMID 20609363
    3. Structure and function of the 5'-->3' exoribonuclease Rat1 and its activating partner Rai1. Xiang S, et al. Nature, 2009 Apr 9. PMID 19194460, Free PMC Article
    4. The dhp1(+) gene, encoding a putative nuclear 5'-->3' exoribonuclease, is required for proper chromosome segregation in fission yeast. Shobuike T, et al. Nucleic Acids Res, 2001 Mar 15. PMID 11238999, Free PMC Article
    5. Involvement of fission yeast Pdc2 in RNA degradation and P-body function. Wang CY, et al. RNA, 2017 Apr. PMID 28031482, Free PMC Article

    See all (20) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Hypomodified tRNA in evolutionarily distant yeasts can trigger rapid tRNA decay to activate the general amino acid control response, but with different consequences.
      Title: Hypomodified tRNA in evolutionarily distant yeasts can trigger rapid tRNA decay to activate the general amino acid control response, but with different consequences.
    2. A function of Pdc2-Lsm1, in concert with Dhp1, regulating RNA by promoting its decapping/destruction in the nucleus of Schizosaccharomyces pombe was suggested.
      Title: Involvement of fission yeast Pdc2 in RNA degradation and P-body function.
    3. Dhp1 interacts with the Clr4/Suv39h methyltransferase complex and acts directly to nucleate heterochromatin. Our work uncovers a previously unidentified role for 3'-end processing and transcription termination machinery in gene silencing.
      Title: Conserved factor Dhp1/Rat1/Xrn2 triggers premature transcription termination and nucleates heterochromatin to promote gene silencing.
    4. Pac1 and Dhp1p are essential for RNA production and transcript termination.
      Title: Pac1 endonuclease and Dhp1p 5'-->3' exonuclease are required for U3 snoRNA termination in Schizosaccharomyces pombe.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by PomBase

    Function Evidence Code Pubs
    enables 5'-3' RNA exonuclease activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables 5'-3' RNA exonuclease activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables RNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in cleavage in ITS2 between 5.8S rRNA and LSU-rRNA of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) IC
    Inferred by Curator
    more info
    		  
    involved_in nuclear mRNA surveillance ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in nuclear-transcribed mRNA catabolic process EXP
    Inferred from Experiment
    more info
    		 PubMed 
    involved_in nuclear-transcribed mRNA catabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in nuclear-transcribed mRNA catabolic process IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in tRNA decay EXP
    Inferred from Experiment
    more info
    		 PubMed 
    involved_in tRNA surveillance IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    Component Evidence Code Pubs
    part_of Las1 complex ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in nucleus HDA PubMed 
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in nucleus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    5'-3' exoribonuclease Dhp1
    NP_594155.1

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003424.3 Reference assembly

      Range
      3356144..3361083 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001019579.2 → NP_594155.1  5'-3' exoribonuclease Dhp1 [Schizosaccharomyces pombe]

      See identical proteins and their annotated locations for NP_594155.1

      Status: PROVISIONAL

      UniProtKB/Swiss-Prot
      P40848
      Conserved Domains (2) summary
      COG5049
      Location:1 → 981
      XRN1; 5'-3' exonuclease [Replication, recombination and repair]
      pfam03159
      Location:1 → 255
      XRN_N; XRN 5'-3' exonuclease N-terminus
    Nucleotide Protein
    Heading Accession and Version

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