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    MYO4 myosin 4 [ Saccharomyces cerevisiae S288C ]

    Gene ID: 851204, updated on 2-Nov-2024

    Summary

    Official Symbol
    MYO4
    Official Full Name
    myosin 4
    Primary source
    SGD:S000000027
    Locus tag
    YAL029C
    See related
    AllianceGenome:SGD:S000000027; FungiDB:YAL029C; VEuPathDB:YAL029C
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Also known as
    FUN22; SHE1
    Summary
    Enables actin filament binding activity and microfilament motor activity. Involved in endoplasmic reticulum inheritance; intracellular mRNA localization; and mating type switching. Located in cellular bud tip. Part of filamentous actin. Used to study Griscelli syndrome type 1; cerebrovascular disease; melanoma; and microvillus inclusion disease. Human ortholog(s) of this gene implicated in Griscelli syndrome type 1; microvillus inclusion disease; and progressive familial intrahepatic cholestasis. Orthologous to human MYO5A (myosin VA) and MYO5B (myosin VB). [provided by Alliance of Genome Resources, Nov 2024]
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    Genomic context

    See MYO4 in Genome Data Viewer
    Location:
    chromosome: I
    Exon count:
    1
    Sequence:
    Chromosome: I; NC_001133.9 (87855..92270, complement)

    Chromosome I - NC_001133.9Genomic Context describing neighboring genes Neighboring gene protein phosphatase regulator GIP4 Neighboring gene SNAP receptor SNC1 Neighboring gene Frt2p Neighboring gene DNA-binding protein SAW1

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables actin binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables actin filament binding IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables actin filament binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables calmodulin binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables cytoskeletal motor activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables microfilament motor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables microfilament motor activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    Process Evidence Code Pubs
    involved_in actin filament organization IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in endoplasmic reticulum inheritance IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in intracellular mRNA localization IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in intracellular mRNA localization IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    involved_in mRNA transport IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in mating type switching IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in vesicle transport along actin filament IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    Component Evidence Code Pubs
    is_active_in actin cytoskeleton IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in actin cytoskeleton IEA
    Inferred from Electronic Annotation
    more info
     
    located_in cellular bud IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in cellular bud IEA
    Inferred from Electronic Annotation
    more info
     
    located_in cellular bud tip IDA
    Inferred from Direct Assay
    more info
    PubMed 
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    part_of filamentous actin IDA
    Inferred from Direct Assay
    more info
    PubMed 
    is_active_in membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in mitochondrion HDA PubMed 
    part_of myosin complex IEA
    Inferred from Electronic Annotation
    more info
     
    is_active_in vesicle IBA
    Inferred from Biological aspect of Ancestor
    more info
     

    General protein information

    Preferred Names
    myosin 4
    NP_009373.1
    • Type V myosin motor involved in actin-based transport of cargos; required for mRNA transport, including ASH1 mRNA, and facilitating the growth and movement of ER tubules into the growing bud along with She3p; MYO4 has a paralog, MYO2, that arose from the whole genome duplication

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001133.9 Reference assembly

      Range
      87855..92270 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001178174.1NP_009373.1  TPA: myosin 4 [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_009373.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D6VPI9, P32492
      UniProtKB/TrEMBL
      B5VDJ1, C8Z3J7, N1P7J3
      Conserved Domains (1) summary
      COG5022
      Location:21471
      COG5022; Myosin heavy chain [General function prediction only]