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    CUE3 Cue3p [ Saccharomyces cerevisiae S288C ]

    Gene ID: 852768, updated on 28-Oct-2024

    Summary

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    Official Symbol
    CUE3
    Official Full Name
    Cue3p
    Primary source
    SGD:S000003078
    Locus tag
    YGL110C
    See related
    AllianceGenome:SGD:S000003078; FungiDB:YGL110C; VEuPathDB:YGL110C
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Also known as
    RQT3
    Summary
    Enables K63-linked polyubiquitin modification-dependent protein binding activity and ubiquitin binding activity. Involved in rescue of stalled ribosome. Is active in cytosolic ribosome. [provided by Alliance of Genome Resources, Oct 2024]
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    Genomic context

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    See CUE3 in Genome Data Viewer
    Location:
    chromosome: VII
    Exon count:
    1
    Sequence:
    Chromosome: VII; NC_001139.9 (301537..303411, complement)

    Chromosome VII - NC_001139.9Genomic Context describing neighboring genes Neighboring gene TATA-binding protein-associated factor TAF6 Neighboring gene ribosome biosynthesis protein NSA1 Neighboring gene uncharacterized protein Neighboring gene Rmd9p

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001139.9

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Asc1, Hel2, and Slh1 couple translation arrest to nascent chain degradation. Sitron CS, et al. RNA, 2017 May. PMID 28223409, Free PMC Article
    2. Decoding of the ubiquitin code for clearance of colliding ribosomes by the RQT complex. Matsuo Y, et al. Nat Commun, 2023 Jan 10. PMID 36627279, Free PMC Article
    3. RQT complex dissociates ribosomes collided on endogenous RQC substrate SDD1. Matsuo Y, et al. Nat Struct Mol Biol, 2020 Apr. PMID 32203490
    4. A ubiquitin-binding motif required for intramolecular monoubiquitylation, the CUE domain. Shih SC, et al. EMBO J, 2003 Mar 17. PMID 12628920, Free PMC Article
    5. Ubiquitination of stalled ribosome triggers ribosome-associated quality control. Matsuo Y, et al. Nat Commun, 2017 Jul 31. PMID 28757607, Free PMC Article

    See all (43) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables K63-linked polyubiquitin modification-dependent protein binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables ubiquitin binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables ubiquitin binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables ubiquitin binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in rescue of stalled ribosome IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in rescue of stalled ribosome IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    is_active_in cytoplasm HDA PubMed 
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in cytosolic ribosome IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    Cue3p
    NP_011405.1
    • Subunit of ribosome-associated quality control trigger complex (RQT); has a CUE domain that binds ubiquitin, which may facilitate intramolecular monoubiquitination

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001139.9 Reference assembly

      Range
      301537..303411 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001180975.1 → NP_011405.1  TPA: Cue3p [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_011405.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D6VU37, P53137
      UniProtKB/TrEMBL
      C7GM04, N1P5D8
      Conserved Domains (1) summary
      cd14373
      Location:318 → 358
      CUE_Cue3p_like; CUE domain found in yeast ubiquitin-binding protein CUE3 (Cue3p) and similar proteins
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P53137.1

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