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    phosphatidylinositol/phosphatidylcholine-binding protein [ Saccharomyces cerevisiae S288C ]

    Gene ID: 853771, updated on 2-Nov-2024

    Summary

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    Official Full Name
    phosphatidylinositol/phosphatidylcholine-binding protein
    Primary source
    SGD:S000001574
    Locus tag
    YKL091C
    See related
    AllianceGenome:SGD:S000001574; FungiDB:YKL091C; VEuPathDB:YKL091C
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Also known as
    SFH1
    Summary
    Enables phosphatidylcholine binding activity and phosphatidylinositol binding activity. Located in nucleus. Orthologous to several human genes including SEC14L2 (SEC14 like lipid binding 2); SEC14L3 (SEC14 like lipid binding 3); and SEC14L4 (SEC14 like lipid binding 4). [provided by Alliance of Genome Resources, Nov 2024]
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    Genomic context

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    Location:
    chromosome: XI
    Exon count:
    1
    Sequence:
    Chromosome: XI; NC_001143.9 (269718..270650, complement)

    Chromosome XI - NC_001143.9Genomic Context describing neighboring genes Neighboring gene Mbr1p Neighboring gene GTPase-activating protein BUD2 Neighboring gene Cue2p Neighboring gene Mif2p

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001143.9

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Crystallization and preliminary X-ray diffraction analysis of phospholipid-bound Sfh1p, a member of the Saccharomyces cerevisiae Sec14p-like phosphatidylinositol transfer protein family. Schaaf G, et al. Acta Crystallogr Sect F Struct Biol Cryst Commun, 2006 Nov 1. PMID 17077504, Free PMC Article
    2. Structural elements that govern Sec14-like PITP sensitivities to potent small molecule inhibitors. Khan D, et al. J Lipid Res, 2016 Apr. PMID 26921357, Free PMC Article
    3. Functional anatomy of phospholipid binding and regulation of phosphoinositide homeostasis by proteins of the sec14 superfamily. Schaaf G, et al. Mol Cell, 2008 Feb 1. PMID 18243114, Free PMC Article
    4. Resurrection of a functional phosphatidylinositol transfer protein from a pseudo-Sec14 scaffold by directed evolution. Schaaf G, et al. Mol Biol Cell, 2011 Mar 15. PMID 21248202, Free PMC Article
    5. Subcellular localization of yeast Sec14 homologues and their involvement in regulation of phospholipid turnover. Schnabl M, et al. Eur J Biochem, 2003 Aug. PMID 12869188

    See all (28) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables phosphatidylcholine binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables phosphatidylinositol binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in biological_process ND
    No biological Data available
    more info
    		  
    Component Evidence Code Pubs
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    phosphatidylinositol/phosphatidylcholine-binding protein
    NP_012832.1
    • Putative phosphatidylinositol/phosphatidylcholine transfer protein; possibly involved in lipid metabolism; localizes to the nucleus; contains a CRAL/TRIO domain and binds several lipids in a large-scale study; YKL091C has a paralog, SEC14, that arose from the whole genome duplication

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001143.9 Reference assembly

      Range
      269718..270650 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001179657.1 → NP_012832.1  TPA: phosphatidylinositol/phosphatidylcholine-binding protein [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_012832.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D6VXJ7, P33324
      UniProtKB/TrEMBL
      A6ZZM6, B3LR03, B5VM66, C7GVL9, C8ZC84, G2WHU2, N1P0I1
      Conserved Domains (2) summary
      smart00516
      Location:101 → 271
      SEC14; Domain in homologues of a S. cerevisiae phosphatidylinositol transfer protein (Sec14p)
      smart01100
      Location:30 → 75
      CRAL_TRIO_N; CRAL/TRIO, N-terminal domain
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P33324.2

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