U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Links from GEO Profiles

    • Showing Current items.

    HIT1 Hit1p [ Saccharomyces cerevisiae S288C ]

    Gene ID: 853516, updated on 17-May-2024

    Summary

    Go to the top of the page Help
    Gene symbol
    HIT1
    Gene description
    Hit1p
    Primary source
    FungiDB:YJR055W
    Locus tag
    YJR055W
    See related
    SGD:S000003816; AllianceGenome:SGD:S000003816; VEuPathDB:YJR055W
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Summary
    Predicted to enable metal ion binding activity. Involved in box C/D snoRNP assembly and maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA). Located in cytoplasm and nucleus. Human ortholog(s) of this gene implicated in PEHO syndrome. Orthologous to human ZNHIT3 (zinc finger HIT-type containing 3). [provided by Alliance of Genome Resources, Apr 2022]
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    Go to the top of the page Help
    See HIT1 in Genome Data Viewer
    Location:
    chromosome: X
    Exon count:
    1
    Sequence:
    Chromosome: X; NC_001142.9 (538772..539266)

    Chromosome X - NC_001142.9Genomic Context describing neighboring genes Neighboring gene Kch1p Neighboring gene tRNA-Arg Neighboring gene tRNA-Asp Neighboring gene uncharacterized protein

    Genomic regions, transcripts, and products

    Go to the top of the page Help
    Genomic Sequence:
    NC_001142.9

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

    Go to the top of the pageHelp

    Related articles in PubMed

    1. Studies of mutations of assembly factor Hit1 in budding yeast suggest translation defects as the molecular basis for PEHO syndrome. Dreggors-Walker RE, et al. J Biol Chem, 2022 Sep. PMID 35843310, Free PMC Article
    2. Box C/D snoRNPs: solid-state NMR fingerprint of an early-stage 50 kDa assembly intermediate. Chagot ME, et al. Biomol NMR Assign, 2020 Apr. PMID 32030621
    3. Ty element-induced temperature-sensitive mutations of Saccharomyces cerevisiae. Kawakami K, et al. Genetics, 1992 Aug. PMID 1325386, Free PMC Article
    4. Deletion of a single-copy tRNA affects microtubule function in Saccharomyces cerevisiae. Reijo RA, et al. Genetics, 1993 Dec. PMID 8307335, Free PMC Article
    5. Structural Features of the Box C/D snoRNP Pre-assembly Process Are Conserved through Species. Quinternet M, et al. Structure, 2016 Oct 4. PMID 27594683

    See all (41) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Studies of mutations of assembly factor Hit1 in budding yeast suggest translation defects as the molecular basis for PEHO syndrome.
      Title: Studies of mutations of assembly factor Hit1 in budding yeast suggest translation defects as the molecular basis for PEHO syndrome.
    2. The authors identified structural features associated with the requirement of Hit1p and Bcd1p zinc finger-HIT domain for cell growth and box C/D snoRNA stability under heat stress. Altogether, the data suggest an important role of zinc finger-HIT domain could be to maintain functional folding to the rest of the protein, especially under heat stress conditions.
      Title: Functional and Structural Insights of the Zinc-Finger HIT protein family members Involved in Box C/D snoRNP Biogenesis.
    3. Thus study identified the protein Hit1 as a novel Rsa1p-interacting partner involved in C/D snoRNP assembly.
      Title: Protein Hit1, a novel box C/D snoRNP assembly factor, controls cellular concentration of the scaffolding protein Rsa1 by direct interaction.
    Submit: New GeneRIF Correction

    Interactions

    Go to the top of the page Help
    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Go to the top of the page Help

    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables zinc ion binding RCA
    inferred from Reviewed Computational Analysis
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in box C/D snoRNP assembly IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in box C/D snoRNP assembly IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in snoRNA localization IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    located_in cytoplasm HDA PubMed 
    located_in nucleus HDA PubMed 
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of pre-snoRNP complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

    Go to the top of the page Help
    Preferred Names
    Hit1p
    NP_012589.1
    • Protein involved in C/D snoRNP assembly; critical for formation of small nucleolar ribonucleoprotein complexes that are required for rRNA processing and 2'-O-methylation; regulates abundance of Rsa1p; required for growth at high temperature; mutations in human homolog ZNHIT3 cause PEHO syndrome, a ribosomopathy characterized by extreme cerebellar atrophy

    NCBI Reference Sequences (RefSeq)

    Go to the top of the page Help

    NEW Try the new Transcript table

    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001142.9 Reference assembly

      Range
      538772..539266
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001181713.1 → NP_012589.1  TPA: Hit1p [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_012589.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D6VWM6, P46973
      UniProtKB/TrEMBL
      A6ZQ14, G2WH60
      Conserved Domains (2) summary
      pfam04438
      Location:4 → 34
      zf-HIT; HIT zinc finger
      pfam18268
      Location:79 → 159
      Hit1_C; Hit1 C-terminal
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P46973.1

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Other Literature Sources
    Molecular Biology Databases
    Research Materials
    Tools