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    spb70 DNA polymerase alpha B-subunit [ Schizosaccharomyces pombe (fission yeast) ]

    Gene ID: 2539135, updated on 18-Sep-2024

    Summary

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    Official Symbol
    spb70
    Official Full Name
    DNA polymerase alpha B-subunit
    Primary source
    PomBase:SPCC553.09c
    Locus tag
    SPOM_SPCC553.09C
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Schizosaccharomyces pombe (strain: 972h-)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Taphrinomycotina; Schizosaccharomycetes; Schizosaccharomycetales; Schizosaccharomycetaceae; Schizosaccharomyces
    Also known as
    pol12
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    Genomic context

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    See spb70 in Genome Data Viewer
    Location:
    chromosome: III
    Exon count:
    4
    Sequence:
    Chromosome: III; NC_003421.2 (287229..289704)

    Chromosome III - NC_003421.2Genomic Context describing neighboring genes Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene GTPase Ria1 Neighboring gene ncRNA Neighboring gene DinB-like DNA repair polymerase kappa Neighboring gene oligosaccharyltransferase delta subunit Swp1

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003421.2

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. The B-subunit of DNA polymerase alpha-primase associates with the origin recognition complex for initiation of DNA replication. Uchiyama M, et al. Mol Cell Biol, 2004 Sep. PMID 15314153, Free PMC Article
    2. Primer utilization by DNA polymerase alpha-primase is influenced by its interaction with Mcm10p. Fien K, et al. J Biol Chem, 2004 Apr 16. PMID 14766746
    3. DNA replication machinery prevents Rad52-dependent single-strand annealing that leads to gross chromosomal rearrangements at centromeres. Onaka AT, et al. Commun Biol, 2020 Apr 30. PMID 32355220, Free PMC Article
    4. Pfh1 Is an Accessory Replicative Helicase that Interacts with the Replisome to Facilitate Fork Progression and Preserve Genome Integrity. McDonald KR, et al. PLoS Genet, 2016 Sep. PMID 27611590, Free PMC Article
    5. Phosphorylation of the RNA-binding protein Zfs1 modulates sexual differentiation in fission yeast. Navarro FJ, et al. J Cell Sci, 2017 Dec 15. PMID 29084823, Free PMC Article

    See all (8) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by PomBase

    Function Evidence Code Pubs
    enables DNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in DNA replication initiation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in DNA replication, synthesis of primer IC
    Inferred by Curator
    more info
    		 PubMed 
    involved_in mitotic DNA replication initiation IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Component Evidence Code Pubs
    part_of alpha DNA polymerase:primase complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of alpha DNA polymerase:primase complex IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    is_active_in chromatin IC
    Inferred by Curator
    more info
    		 PubMed 
    is_active_in cytosol HDA PubMed 
    is_active_in nucleus HDA PubMed 

    General protein information

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    Preferred Names
    DNA polymerase alpha B-subunit

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003421.2 Reference assembly

      Range
      287229..289704
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001022758.3 → NP_587765.1  DNA polymerase alpha B-subunit [Schizosaccharomyces pombe]

      See identical proteins and their annotated locations for NP_587765.1

      Status: PROVISIONAL

      UniProtKB/Swiss-Prot
      O74946
      Conserved Domains (3) summary
      COG5214
      Location:1 → 574
      POL12; DNA polymerase alpha-primase complex, polymerase-associated subunit B [DNA replication, recombination, and repair]
      pfam04042
      Location:307 → 518
      DNA_pol_E_B; DNA polymerase alpha/epsilon subunit B
      pfam08418
      Location:7 → 198
      Pol_alpha_B_N; DNA polymerase alpha subunit B N-terminal
    Nucleotide Protein
    Heading Accession and Version

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