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    RRP14 ribosome biosynthesis protein RRP14 [ Saccharomyces cerevisiae S288C ]

    Gene ID: 853780, updated on 17-May-2024

    Summary

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    Gene symbol
    RRP14
    Gene description
    ribosome biosynthesis protein RRP14
    Primary source
    FungiDB:YKL082C
    Locus tag
    YKL082C
    See related
    SGD:S000001565; AllianceGenome:SGD:S000001565; VEuPathDB:YKL082C
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Summary
    Predicted to enable DNA binding activity and RNA binding activity. Involved in ribosomal large subunit biogenesis and ribosomal small subunit biogenesis. Located in nucleolus. Orthologous to human SURF6 (surfeit 6). [provided by Alliance of Genome Resources, Apr 2022]
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    Genomic context

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    See RRP14 in Genome Data Viewer
    Location:
    chromosome: XI
    Exon count:
    1
    Sequence:
    Chromosome: XI; NC_001143.9 (281025..282329, complement)

    Chromosome XI - NC_001143.9Genomic Context describing neighboring genes Neighboring gene malate dehydrogenase MDH1 Neighboring gene Hot13p Neighboring gene translation elongation factor EF1B gamma Neighboring gene ncRNA Neighboring gene H(+)-transporting V1 sector ATPase subunit C

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001143.9

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Yeast Rrp14p is required for ribosomal subunit synthesis and for correct positioning of the mitotic spindle during mitosis. Oeffinger M, et al. Nucleic Acids Res, 2007. PMID 17272295, Free PMC Article
    2. Identification of an evolutionary conserved SURF-6 domain in a family of nucleolar proteins extending from human to yeast. Polzikov M, et al. Biochem Biophys Res Commun, 2005 Feb 4. PMID 15629442
    3. Yeast Rrp14p is a nucleolar protein involved in both ribosome biogenesis and cell polarity. Yamada H, et al. RNA, 2007 Nov. PMID 17804645, Free PMC Article
    4. Evolutionarily conserved function of RRP36 in early cleavages of the pre-rRNA and production of the 40S ribosomal subunit. Gérus M, et al. Mol Cell Biol, 2010 Mar. PMID 20038530, Free PMC Article
    5. Ebp2 and Brx1 function cooperatively in 60S ribosomal subunit assembly in Saccharomyces cerevisiae. Shimoji K, et al. Nucleic Acids Res, 2012 May. PMID 22319211, Free PMC Article

    See all (53) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. These results suggest that Rrp14p has dual functions in ribosome synthesis and polarized cell growth.
      Title: Yeast Rrp14p is a nucleolar protein involved in both ribosome biogenesis and cell polarity.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables DNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables RNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables molecular_function ND
    No biological Data available
    more info
    		  
    Process Evidence Code Pubs
    involved_in rRNA processing IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in ribosomal large subunit biogenesis IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in ribosomal large subunit biogenesis IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in ribosomal small subunit biogenesis IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in ribosomal small subunit biogenesis IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in ribosome biogenesis IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    is_active_in nucleolus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleolus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in nucleolus IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    ribosome biosynthesis protein RRP14
    NP_012841.1
    • Essential protein, constituent of 66S pre-ribosomal particles; interacts with proteins involved in ribosomal biogenesis and cell polarity; member of the SURF-6 family

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001143.9 Reference assembly

      Range
      281025..282329 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001179648.1 → NP_012841.1  TPA: ribosome biosynthesis protein RRP14 [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_012841.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D6VXK5, P36080
      UniProtKB/TrEMBL
      A0A6A5PV80, A6ZZN5, B5VM74, C7GVM6, C8ZC91, G2WHV0, N1P0J0
      Conserved Domains (2) summary
      pfam04935
      Location:221 → 400
      SURF6; Surfeit locus protein 6
      pfam15459
      Location:8 → 58
      RRP14; 60S ribosome biogenesis protein Rrp14
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P36080.1

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