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    GLG2 glycogenin glucosyltransferase GLG2 [ Saccharomyces cerevisiae S288C ]

    Gene ID: 853304, updated on 17-May-2024

    Summary

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    Gene symbol
    GLG2
    Gene description
    glycogenin glucosyltransferase GLG2
    Primary source
    FungiDB:YJL137C
    Locus tag
    YJL137C
    See related
    SGD:S000003673; AllianceGenome:SGD:S000003673; VEuPathDB:YJL137C
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Summary
    Enables glycogenin glucosyltransferase activity. Involved in glycogen biosynthetic process. Located in cytoplasm. Human ortholog(s) of this gene implicated in glycogen storage disease and glycogen storage disease XV. Orthologous to several human genes including GYG1 (glycogenin 1). [provided by Alliance of Genome Resources, Apr 2022]
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    Genomic context

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    See GLG2 in Genome Data Viewer
    Location:
    chromosome: X
    Exon count:
    1
    Sequence:
    Chromosome: X; NC_001142.9 (154985..156127, complement)

    Chromosome X - NC_001142.9Genomic Context describing neighboring genes Neighboring gene mannosyltransferase YUR1 Neighboring gene translation initiation factor eIF4A Neighboring gene uncharacterized protein Neighboring gene ribosomal 40S subunit protein S21B

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001142.9

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. GNN is a self-glucosylating protein involved in the initiation step of glycogen biosynthesis in Neurospora crassa. de Paula RM, et al. Arch Biochem Biophys, 2005 Mar 1. PMID 15680913
    2. Yeast glycogenin (Glg2p) produced in Escherichia coli is simultaneously glucosylated at two vicinal tyrosine residues but results in a reduced bacterial glycogen accumulation. Albrecht T, et al. Eur J Biochem, 2004 Oct. PMID 15479227
    3. Initiation of glycogen synthesis in yeast. Requirement of multiple tyrosine residues for function of the self-glucosylating Glg proteins in vivo. Mu J, et al. J Biol Chem, 1996 Oct 25. PMID 8900126
    4. Requirement of the self-glucosylating initiator proteins Glg1p and Glg2p for glycogen accumulation in Saccharomyces cerevisiae. Cheng C, et al. Mol Cell Biol, 1995 Dec. PMID 8524228, Free PMC Article
    5. Regulation of glycogen synthase. Identification of residues involved in regulation by the allosteric ligand glucose-6-P and by phosphorylation. Pederson BA, et al. J Biol Chem, 2000 Sep 8. PMID 10874034

    See all (31) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables UDP-alpha-D-glucose:glucosyl-glycogenin alpha-D-glucosyltransferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables glycogenin glucosyltransferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables glycogenin glucosyltransferase activity IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    enables glycosyltransferase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables glycosyltransferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables transferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in glycogen biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in glycogen biosynthetic process IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in cytoplasm HDA PubMed 
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    glycogenin glucosyltransferase GLG2
    NP_012398.1
    • Glycogenin glucosyltransferase; self-glucosylating initiator of glycogen synthesis, also glucosylates n-dodecyl-beta-D-maltoside; similar to mammalian glycogenin; GLG2 has a paralog, GLG1, that arose from the whole genome duplication

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001142.9 Reference assembly

      Range
      154985..156127 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001181570.1 → NP_012398.1  TPA: glycogenin glucosyltransferase GLG2 [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_012398.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      A6ZQJ2, D6VW47, P47011
      UniProtKB/TrEMBL
      A0A8H4FAN5, B3LPY0, C7GPZ1, C8ZB80
      Conserved Domains (1) summary
      cd02537
      Location:5 → 279
      GT8_Glycogenin; Glycogenin belongs the GT 8 family and initiates the biosynthesis of glycogen
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P47011.1

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