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    UBP12 putative ubiquitin-specific protease UBP12 [ Saccharomyces cerevisiae S288C ]

    Gene ID: 853242, updated on 7-Jul-2024

    Summary

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    Gene symbol
    UBP12
    Gene description
    putative ubiquitin-specific protease UBP12
    Primary source
    FungiDB:YJL197W
    Locus tag
    YJL197W
    See related
    SGD:S000003733; AllianceGenome:SGD:S000003733; VEuPathDB:YJL197W
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Summary
    Enables thiol-dependent deubiquitinase. Involved in negative regulation of mitochondrial fusion; protein deubiquitination; and regulation of response to DNA damage stimulus. Located in nuclear replication fork. Orthologous to several human genes including USP11 (ubiquitin specific peptidase 11) and USP4 (ubiquitin specific peptidase 4). [provided by Alliance of Genome Resources, Apr 2022]
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    Genomic context

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    See UBP12 in Genome Data Viewer
    Location:
    chromosome: X
    Exon count:
    1
    Sequence:
    Chromosome: X; NC_001142.9 (63805..67569)

    Chromosome X - NC_001142.9Genomic Context describing neighboring genes Neighboring gene Mbb1p Neighboring gene SPX domain-containing inorganic phosphate transporter Neighboring gene fatty acid elongase ELO1 Neighboring gene AAA family ATPase CDC6

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001142.9

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Differential regulation of G protein alpha subunit trafficking by mono- and polyubiquitination. Wang Y, et al. J Biol Chem, 2005 Jan 7. PMID 15519996
    2. Two deubiquitylases act on mitofusin and regulate mitochondrial fusion along independent pathways. Anton F, et al. Mol Cell, 2013 Feb 7. PMID 23317502
    3. The deubiquitylating enzyme Ubp12 regulates Rad23-dependent proteasomal degradation. Gödderz D, et al. J Cell Sci, 2017 Oct 1. PMID 28966167
    4. PCNA Deubiquitylases Control DNA Damage Bypass at Replication Forks. Álvarez V, et al. Cell Rep, 2019 Oct 29. PMID 31665643
    5. Cdc48 regulates a deubiquitylase cascade critical for mitochondrial fusion. Simões T, et al. Elife, 2018 Jan 8. PMID 29309037, Free PMC Article

    See all (43) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Ubp12 removes short ubiquitin chains from the N-terminal ubiquitin-like domain (UbL) of Rad23.
      Title: The deubiquitylating enzyme Ubp12 regulates Rad23-dependent proteasomal degradation.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables cysteine-type deubiquitinase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables cysteine-type deubiquitinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables cysteine-type peptidase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in DNA damage response IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in negative regulation of mitochondrial fusion IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in protein deubiquitination IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in protein deubiquitination IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in protein deubiquitination IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in proteolysis IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in cytoplasm HDA PubMed 
    located_in nuclear replication fork IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in nucleus HDA PubMed 

    General protein information

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    Preferred Names
    putative ubiquitin-specific protease UBP12
    NP_012338.1
    • Ubiquitin-specific protease; cleaves ubiquitin from ubiquitinated proteins; present in the nucleus and cytoplasm

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001142.9 Reference assembly

      Range
      63805..67569
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001181630.1 → NP_012338.1  TPA: putative ubiquitin-specific protease UBP12 [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_012338.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D6VVZ5, P39538
      UniProtKB/TrEMBL
      A0A8H4F980, C8ZB23
      Conserved Domains (1) summary
      COG5560
      Location:99 → 1111
      UBP12; Ubiquitin C-terminal hydrolase [Posttranslational modification, protein turnover, chaperones]
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P39538.1

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