U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Links from GEO Profiles

    • Showing Current items.

    cyr1 adenylate cyclase [ Schizosaccharomyces pombe (fission yeast) ]

    Gene ID: 2540810, updated on 18-Sep-2024

    Summary

    Go to the top of the page Help
    Official Symbol
    cyr1
    Official Full Name
    adenylate cyclase
    Primary source
    PomBase:SPBC19C7.03
    Locus tag
    SPOM_SPBC19C7.03
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Schizosaccharomyces pombe (strain: 972h-)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Taphrinomycotina; Schizosaccharomycetes; Schizosaccharomycetales; Schizosaccharomycetaceae; Schizosaccharomyces
    Also known as
    git2
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    Go to the top of the page Help
    See cyr1 in Genome Data Viewer
    Location:
    chromosome: II
    Exon count:
    1
    Sequence:
    Chromosome: II; NC_003423.3 (2819802..2825220)

    Chromosome II - NC_003423.3Genomic Context describing neighboring genes Neighboring gene N-end-recognizing protein, UBR ubiquitin-protein ligase E3 Ubr1 Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene uncharacterized protein Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA

    Genomic regions, transcripts, and products

    Go to the top of the page Help
    Genomic Sequence:
    NC_003423.3

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

    Go to the top of the pageHelp

    Related articles in PubMed

    1. Adenylyl cyclase activity of the fission yeast Schizosaccharomyces pombe is not regulated by guanyl nucleotides. Engelberg D, et al. FEBS Lett, 1990 Feb 26. PMID 2178979
    2. Adenylyl cyclase is dispensable for vegetative cell growth in the fission yeast Schizosaccharomyces pombe. Maeda T, et al. Proc Natl Acad Sci U S A, 1990 Oct. PMID 2172964, Free PMC Article
    3. Schizosaccharomyces pombe Git1 is a C2-domain protein required for glucose activation of adenylate cyclase. Kao RS, et al. Genetics, 2006 May. PMID 16489217, Free PMC Article
    4. Direct activation of fission yeast adenylyl cyclase by heterotrimeric G protein gpa2. Ogihara H, et al. Kobe J Med Sci, 2004. PMID 15925945
    5. Isolation of a novel gene, moc2, encoding a putative RNA helicase as a suppressor of sterile strains in Schizosaccharomyces pombe. Kawamukai M. Biochim Biophys Acta, 1999 Jul 7. PMID 10395922

    See all (32) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. gpa2 exhibits a direct and GTP-dependent binding to the Ras-associating domain (RAD) of cyr1
      Title: Direct activation of fission yeast adenylyl cyclase by heterotrimeric G protein gpa2.
    Submit: New GeneRIF Correction

    Pathways from PubChem

    Go to the top of the page

    Interactions

    Go to the top of the page Help
    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Go to the top of the page Help

    Homology

    Gene Ontology Provided by PomBase

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables adenylate cyclase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables adenylate cyclase activity IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    enables magnesium ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables manganese ion binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in adenylate cyclase-activating glucose-activated G protein-coupled receptor signaling pathway IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in intracellular signal transduction IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in negative regulation of induction of conjugation with cellular fusion IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in negative regulation of transcription by RNA polymerase II IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    is_active_in cytoplasm IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in plasma membrane NAS
    Non-traceable Author Statement
    more info
    		  

    General protein information

    Go to the top of the page Help
    Preferred Names
    adenylate cyclase

    NCBI Reference Sequences (RefSeq)

    Go to the top of the page Help

    NEW Try the new Transcript table

    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003423.3 Reference assembly

      Range
      2819802..2825220
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001022079.3 → NP_596159.1  adenylate cyclase [Schizosaccharomyces pombe]

      See identical proteins and their annotated locations for NP_596159.1

      Status: PROVISIONAL

      UniProtKB/Swiss-Prot
      P14605
      Conserved Domains (8) summary
      smart00789
      Location:155 → 200
      Ad_cyc_g-alpha; Adenylate cyclase G-alpha binding domain
      smart00044
      Location:1300 → 1488
      CYCc; Adenylyl- / guanylyl cyclase, catalytic domain
      cd00116
      Location:441 → 616
      LRR_RI; Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond ...
      sd00033
      Location:409 → 430
      LRR_RI; leucine-rich repeat [structural motif]
      pfam00481
      Location:1032 → 1268
      PP2C; Protein phosphatase 2C
      pfam13855
      Location:476 → 537
      LRR_8; Leucine rich repeat
      cl00155
      Location:292 → 387
      UBQ; Ubiquitin-like proteins
      cl11967
      Location:1323 → 1519
      Nucleotidyl_cyc_III; Class III nucleotidyl cyclases
    Nucleotide Protein
    Heading Accession and Version

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Molecular Biology Databases
    Research Materials