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    TRM8 tRNA (guanine46-N7)-methyltransferase [ Saccharomyces cerevisiae S288C ]

    Gene ID: 851326, updated on 2-Nov-2024

    Summary

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    Official Symbol
    TRM8
    Official Full Name
    tRNA (guanine46-N7)-methyltransferase
    Primary source
    SGD:S000002360
    Locus tag
    YDL201W
    See related
    AllianceGenome:SGD:S000002360; FungiDB:YDL201W; VEuPathDB:YDL201W
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Summary
    Enables tRNA (guanine(46)-N7)-methyltransferase activity. Involved in tRNA (guanine-N7)-methylation. Located in nucleus. Part of tRNA (m7G46) methyltransferase complex. Orthologous to human METTL1 (methyltransferase 1, tRNA methylguanosine). [provided by Alliance of Genome Resources, Nov 2024]
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    Genomic context

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    See TRM8 in Genome Data Viewer
    Location:
    chromosome: IV
    Exon count:
    1
    Sequence:
    Chromosome: IV; NC_001136.10 (99561..100421)

    Chromosome IV - NC_001136.10Genomic Context describing neighboring genes Neighboring gene Ack1p Neighboring gene mitochondrial 54S ribosomal protein YmL11 Neighboring gene methylated-DNA--protein-cysteine methyltransferase Neighboring gene uncharacterized protein

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001136.10

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Production of yeast tRNA (m(7)G46) methyltransferase (Trm8-Trm82 complex) in a wheat germ cell-free translation system. Matsumoto K, et al. J Biotechnol, 2008 Feb 29. PMID 18164779
    2. tRNA m7G methyltransferase Trm8p/Trm82p: evidence linking activity to a growth phenotype and implicating Trm82p in maintaining levels of active Trm8p. Alexandrov A, et al. RNA, 2005 May. PMID 15811913, Free PMC Article
    3. Structure of the yeast tRNA m7G methylation complex. Leulliot N, et al. Structure, 2008 Jan. PMID 18184583
    4. Hetero subunit interaction and RNA recognition of yeast tRNA (m7G46) methyltransferase synthesized in a wheat germ cell-free translation system. Muneyoshi Y, et al. Nucleic Acids Symp Ser (Oxf), 2007. PMID 18029735
    5. RNA recognition mechanism of eukaryote tRNA (m7G46) methyltransferase (Trm8-Trm82 complex). Matsumoto K, et al. FEBS Lett, 2007 Apr 17. PMID 17382321

    See all (43) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. a second role of Trm82p is to stabilize Trm8p in an active conformation
      Title: tRNA m7G methyltransferase Trm8p/Trm82p: evidence linking activity to a growth phenotype and implicating Trm82p in maintaining levels of active Trm8p.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables methyltransferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables tRNA (guanine(46)-N7)-methyltransferase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables tRNA (guanine(46)-N7)-methyltransferase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables tRNA (guanine(46)-N7)-methyltransferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables tRNA (guanine(46)-N7)-methyltransferase activity IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    enables tRNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in RNA (guanine-N7)-methylation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in methylation IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in tRNA (guanine-N7)-methylation IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in tRNA (guanine-N7)-methylation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in tRNA methylation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in tRNA methylation IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in tRNA modification IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in tRNA processing IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in nucleus HDA PubMed 
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  
    part_of tRNA (m7G46) methyltransferase complex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    part_of tRNA methyltransferase complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    tRNA (guanine46-N7)-methyltransferase
    NP_010080.1
    • Catalytic subunit of a tRNA methyltransferase complex; Trm8p and Trm82p comprise an enzyme that catalyzes a methyl-transfer from S-adenosyl-l-methionine to the N(7) atom of guanine at position 46 in tRNA; Trm8 lacks catalytic activity if not bound to Trm82p

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001136.10 Reference assembly

      Range
      99561..100421
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001180261.1 → NP_010080.1  TPA: tRNA (guanine46-N7)-methyltransferase [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_010080.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      A6ZXD2, B3LH81, D6VRF3, Q12009
      UniProtKB/TrEMBL
      C7GV62, C8Z6A4, G2WBW6, N1P4Z8
      Conserved Domains (1) summary
      TIGR00091
      Location:77 → 281
      TIGR00091; tRNA (guanine-N(7)-)-methyltransferase
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q12009.1

    Gene LinkOut

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