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    EBP2 Ebp2p [ Saccharomyces cerevisiae S288C ]

    Gene ID: 853682, updated on 29-Jun-2024

    Summary

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    Gene symbol
    EBP2
    Gene description
    Ebp2p
    Primary source
    FungiDB:YKL172W
    Locus tag
    YKL172W
    See related
    SGD:S000001655; AllianceGenome:SGD:S000001655; VEuPathDB:YKL172W
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Summary
    Enables mRNA binding activity. Involved in nuclear division and rRNA processing. Located in nuclear periphery and nucleolus. Part of preribosome, large subunit precursor. Orthologous to human EBNA1BP2 (EBNA1 binding protein 2). [provided by Alliance of Genome Resources, Apr 2022]
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    Genomic context

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    See EBP2 in Genome Data Viewer
    Location:
    chromosome: XI
    Exon count:
    1
    Sequence:
    Chromosome: XI; NC_001143.9 (125759..127042)

    Chromosome XI - NC_001143.9Genomic Context describing neighboring genes Neighboring gene Tpo5p Neighboring gene U5 snRNP GTPase SNU114 Neighboring gene protein kinase NNK1 Neighboring gene mitochondrial 54S ribosomal protein YmL38/YmL34

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001143.9

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. A ribosome assembly factor Ebp2p, the yeast homolog of EBNA1-binding protein 2, is involved in the secretory response. Horigome C, et al. Biosci Biotechnol Biochem, 2008 Apr. PMID 18391458
    2. The yeast rRNA biosynthesis factor Ebp2p is also required for efficient nuclear division. Ionescu CN, et al. Yeast, 2004 Oct 30. PMID 15515129
    3. EBP2 is a member of the yeast RRB regulon, a transcriptionally coregulated set of genes that are required for ribosome and rRNA biosynthesis. Wade C, et al. Mol Cell Biol, 2001 Dec. PMID 11713296, Free PMC Article
    4. Ebp2p, yeast homologue of a human protein that interacts with Epstein-Barr virus nuclear antigen 1, is required for pre-rRNA processing and ribosomal subunit assembly. Tsujii R, et al. Genes Cells, 2000 Jul. PMID 10947841
    5. The budding yeast homolog of the human EBNA1-binding protein 2 (Ebp2p) is an essential nucleolar protein required for pre-rRNA processing. Huber MD, et al. J Biol Chem, 2000 Sep 15. PMID 10849420

    See all (113) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. These results suggest that Smy2 and Syh1 may be involved in ribosome biogenesis in relation to Ebp2.
      Title: SMY2 and SYH1 suppress defects in ribosome biogenesis caused by ebp2 mutations.
    2. Depletion of either Ebp2 or Brx1 revealed that Brx1 requires Ebp2 for its stable association with pre-ribosomes, but Ebp2 does not depend on the presence of Brx1 to enter pre-ribosomes.
      Title: Ebp2 and Brx1 function cooperatively in 60S ribosomal subunit assembly in Saccharomyces cerevisiae.
    3. These results suggest that the ribosome biogenesis factors Ebp2 and Rrs1 cooperate with Mps3 to mediate telomere clustering, but not telomere tethering, by binding Sir4.
      Title: Ribosome biogenesis factors bind a nuclear envelope SUN domain protein to cluster yeast telomeres.
    4. SUMO mediates the interaction between Ebp2p and SUMO related proteins and Ebp2p switches its interaction partners via sumoylation.
      Title: SUMO mediates interaction of Ebp2p, the yeast homolog of Epstein-Barr virus nuclear antigen 1-binding protein 2, with a RING finger protein Ris1p.
    5. Ebp2p is implicated in the secretory response, including changes in nucleolar architecture
      Title: A ribosome assembly factor Ebp2p, the yeast homolog of EBNA1-binding protein 2, is involved in the secretory response.
    6. plays a role in nuclear division in yeast and this function is separable from the role it plays in rRNA biosynthesis.
      Title: The yeast rRNA biosynthesis factor Ebp2p is also required for efficient nuclear division.
    Submit: New GeneRIF Correction

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables mRNA binding HDA PubMed 
    Process Evidence Code Pubs
    involved_in nuclear division IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in rRNA processing IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in rRNA processing IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in ribosomal large subunit biogenesis IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in ribosome biogenesis IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    is_active_in nuclear periphery IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nuclear periphery IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in nucleolus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleolus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in nucleolus IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  
    part_of preribosome, large subunit precursor HDA PubMed 
    part_of preribosome, large subunit precursor IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of preribosome, large subunit precursor IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    Ebp2p
    NP_012749.1
    • Protein required for 25S rRNA maturation and 60S ribosomal subunit assembly; localizes to the nucleolus and in foci along nuclear periphery; constituent of 66S pre-ribosomal particles; cooperates with Rrs1p and Mps3p to mediate telomere clustering by binding Sir4p, but is not involved in telomere tethering

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001143.9 Reference assembly

      Range
      125759..127042
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001179738.1 → NP_012749.1  TPA: Ebp2p [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_012749.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D6VX28, P36049
      UniProtKB/TrEMBL
      A0A8H4BY00, B3LQT3, N1P0N4
      Conserved Domains (1) summary
      pfam05890
      Location:173 → 422
      Ebp2; Eukaryotic rRNA processing protein EBP2
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P36049.1

    Gene LinkOut

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