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    hal3 thymidylate synthase [ Schizosaccharomyces pombe (fission yeast) ]

    Gene ID: 2542801, updated on 18-Sep-2024

    Summary

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    Official Symbol
    hal3
    Official Full Name
    thymidylate synthase
    Primary source
    PomBase:SPAC15E1.04
    Locus tag
    SPOM_SPAC15E1.04
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Schizosaccharomyces pombe (strain: 972h-)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Taphrinomycotina; Schizosaccharomycetes; Schizosaccharomycetales; Schizosaccharomycetaceae; Schizosaccharomyces
    Also known as
    tds1
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    Genomic context

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    See hal3 in Genome Data Viewer
    Location:
    chromosome: I
    Exon count:
    1
    Sequence:
    Chromosome: I; NC_003424.3 (3723756..3725936)

    Chromosome I - NC_003424.3Genomic Context describing neighboring genes Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene 60S ribosomal protein eL42 Neighboring gene ethanolamine-phosphate cytidylyltransferase Neighboring gene retromer complex subunit Vps29 Neighboring gene meikin

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003424.3

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. The Schizosaccharomyces pombe fusion gene hal3 encodes three distinct activities. Molero C, et al. Mol Microbiol, 2013 Oct. PMID 23962284
    2. The fission yeast FLCN/FNIP complex augments TORC1 repression or activation in response to amino acid (AA) availability. Calvo IA, et al. iScience, 2021 Nov 19. PMID 34805795, Free PMC Article
    3. Proximity-dependent biotinylation mediated by TurboID to identify protein-protein interaction networks in yeast. Larochelle M, et al. J Cell Sci, 2019 May 31. PMID 31064814
    4. Transcription and chromatin-based surveillance mechanism controls suppression of cryptic antisense transcription. Heo DH, et al. Cell Rep, 2021 Sep 7. PMID 34496258, Free PMC Article
    5. A Proteome-wide Fission Yeast Interactome Reveals Network Evolution Principles from Yeasts to Human. Vo TV, et al. Cell, 2016 Jan 14. PMID 26771498, Free PMC Article

    See all (12) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by PomBase

    Function Evidence Code Pubs
    enables FMN binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables phosphopantothenoylcysteine decarboxylase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables protein phosphatase inhibitor activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables thymidylate synthase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables thymidylate synthase activity IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in coenzyme A biosynthetic process IC
    Inferred by Curator
    more info
    		 PubMed 
    involved_in dTMP biosynthetic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in dTMP biosynthetic process IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in dTTP biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cytosol HDA PubMed 
    is_active_in cytosol IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in mitochondrion IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    thymidylate synthase

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003424.3 Reference assembly

      Range
      3723756..3725936
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001019728.3 → NP_594305.1  thymidylate synthase [Schizosaccharomyces pombe]

      See identical proteins and their annotated locations for NP_594305.1

      Status: PROVISIONAL

      UniProtKB/Swiss-Prot
      Q9UTI7
      Conserved Domains (3) summary
      COG0452
      Location:28 → 330
      CoaBC; Phosphopantothenoylcysteine synthetase/decarboxylase [Coenzyme transport and metabolism]
      pfam00303
      Location:331 → 625
      Thymidylat_synt; Thymidylate synthase
      cl19190
      Location:30 → 201
      Flavoprotein; Flavoprotein
    Nucleotide Protein
    Heading Accession and Version

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