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    TPO3 [ Saccharomyces cerevisiae S288C ]

    Gene ID: 856279, updated on 11-Sep-2024

    Summary

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    Official Symbol
    TPO3
    Primary source
    SGD:S000006360
    Locus tag
    YPR156C
    See related
    AllianceGenome:SGD:S000006360; FungiDB:YPR156C; VEuPathDB:YPR156C
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Summary
    Enables spermine transmembrane transporter activity. Involved in spermine transport. Located in fungal-type vacuole membrane and plasma membrane. [provided by Alliance of Genome Resources, Apr 2022]
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    Genomic context

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    Location:
    chromosome: XVI
    Exon count:
    1
    Sequence:
    Chromosome: XVI; NC_001148.4 (837909..839777, complement)

    Chromosome XVI - NC_001148.4Genomic Context describing neighboring genes Neighboring gene Pin3p Neighboring gene Nca2p Neighboring gene Tda6p Neighboring gene Cur1p

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001148.4

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Candida glabrata drug:H+ antiporter CgTpo3 (ORF CAGL0I10384g): role in azole drug resistance and polyamine homeostasis. Costa C, et al. J Antimicrob Chemother, 2014 Jul. PMID 24576949
    2. Combined roles of exporters in acetic acid tolerance in Saccharomyces cerevisiae. Zhang X, et al. Biotechnol Biofuels Bioprod, 2022 Jun 18. PMID 35717394, Free PMC Article
    3. Multiple polyamine transport systems on the vacuolar membrane in yeast. Tomitori H, et al. Biochem J, 2001 Feb 1. PMID 11171066, Free PMC Article
    4. Identification of the TPO1 gene in yeast, and its human orthologue TETRAN, which cause resistance to NSAIDs. Mima S, et al. FEBS Lett, 2007 Apr 3. PMID 17362938
    5. Localization and function of the yeast multidrug transporter Tpo1p. Albertsen M, et al. J Biol Chem, 2003 Apr 11. PMID 12562762

    See all (35) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables antiporter activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables spermine transmembrane transporter activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables spermine transmembrane transporter activity IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    enables transmembrane transporter activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in spermine transmembrane transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in spermine transport IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in spermine transport IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in transmembrane transport IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in transmembrane transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in cell periphery HDA PubMed 
    is_active_in fungal-type vacuole membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in fungal-type vacuole membrane IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in plasma membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in plasma membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    spermine transporter
    NP_015482.1
    • Polyamine transporter of major facilitator superfamily; member of 12-spanner drug:H(+) antiporter DHA1 family; specific for spermine; localizes to plasma membrane; targeted to vacuole via AP-3 pathway; TPO3 has a paralog, TPO2, that arose from the whole genome duplication

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001148.4 Reference assembly

      Range
      837909..839777 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001184253.1 → NP_015482.1  TPA: spermine transporter [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_015482.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D6W4F2, Q06451
      UniProtKB/TrEMBL
      B3LKB6
      Conserved Domains (1) summary
      cd17323
      Location:182 → 608
      MFS_Tpo1_MDR_like; Yeast Polyamine transporter 1 (Tpo1) and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q06451.1

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