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    NMD2 Nmd2p [ Saccharomyces cerevisiae S288C ]

    Gene ID: 856476, updated on 17-May-2024

    Summary

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    Gene symbol
    NMD2
    Gene description
    Nmd2p
    Primary source
    FungiDB:YHR077C
    Locus tag
    YHR077C
    See related
    SGD:S000001119; AllianceGenome:SGD:S000001119; VEuPathDB:YHR077C
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Also known as
    IFS1; SUA1; SUP111; UPF2
    Summary
    Predicted to enable RNA binding activity. Involved in DNA recombination and nuclear-transcribed mRNA catabolic process, 3'-5' exonucleolytic nonsense-mediated decay. Located in cytoplasm. Part of polysome. Orthologous to human UPF2 (UPF2 regulator of nonsense mediated mRNA decay). [provided by Alliance of Genome Resources, Apr 2022]
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    Genomic context

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    See NMD2 in Genome Data Viewer
    Location:
    chromosome: VIII
    Exon count:
    2
    Sequence:
    Chromosome: VIII; NC_001140.6 (252374..255756, complement)

    Chromosome VIII - NC_001140.6Genomic Context describing neighboring genes Neighboring gene phosphoprotein phosphatase methylesterase 1 Neighboring gene type 2C protein phosphatase PTC7 Neighboring gene uncharacterized protein Neighboring gene bifunctional endoribonuclease/protein kinase IRE1

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001140.6

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Transcript selection and the recruitment of mRNA decay factors for NMD in Saccharomyces cerevisiae. Culbertson MR, et al. RNA, 2005 Sep. PMID 16043493, Free PMC Article
    2. Identification and characterization of genes that are required for the accelerated degradation of mRNAs containing a premature translational termination codon. Cui Y, et al. Genes Dev, 1995 Feb 15. PMID 7883167
    3. Nonsense-mediated decay mutants do not affect programmed -1 frameshifting. Bidou L, et al. RNA, 2000 Jul. PMID 10917592, Free PMC Article
    4. Aberrant mRNAs with extended 3' UTRs are substrates for rapid degradation by mRNA surveillance. Muhlrad D, et al. RNA, 1999 Oct. PMID 10573121, Free PMC Article
    5. Interaction between Nmd2p and Upf1p is required for activity but not for dominant-negative inhibition of the nonsense-mediated mRNA decay pathway in yeast. He F, et al. RNA, 1996 Feb. PMID 8601282, Free PMC Article

    See all (130) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Upf2p phosphorylation is crucial for nonsense-mediated mRNA decay (NMD) pathway.
      Title: Role for Upf2p phosphorylation in Saccharomyces cerevisiae nonsense-mediated mRNA decay.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables RNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables molecular_function ND
    No biological Data available
    more info
    		  
    Process Evidence Code Pubs
    involved_in DNA recombination IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in nuclear-transcribed mRNA catabolic process, 3'-5' exonucleolytic nonsense-mediated decay IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in nuclear-transcribed mRNA catabolic process, nonsense-mediated decay IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in nuclear-transcribed mRNA catabolic process, nonsense-mediated decay IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in nuclear-transcribed mRNA catabolic process, nonsense-mediated decay IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytoplasm IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    part_of exon-exon junction complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    Nmd2p
    NP_011944.2
    • Protein involved in the nonsense-mediated mRNA decay (NMD) pathway; acts as a scaffold protein bridging Nam7p and Upf3p; involved in telomere maintenance; contains an acidic domain and three middle domains of eukaryotic initiation factor 4G (mIF4G) with aspartic 59 of mIF4G-1 important for NMD activity and translation termination accuracy

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001140.6 Reference assembly

      Range
      252374..255756 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001179207.1 → NP_011944.2  TPA: Nmd2p [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_011944.2

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D3DL27, P38798
      UniProtKB/TrEMBL
      B3LSJ5
      Conserved Domains (3) summary
      smart00543
      Location:374 → 561
      MIF4G; Middle domain of eukaryotic initiation factor 4G (eIF4G)
      pfam02854
      Location:34 → 241
      MIF4G; MIF4G domain
      pfam04050
      Location:976 → 1084
      Upf2; Up-frameshift suppressor 2
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P38798.2

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