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    pku70 Ku domain protein Pku70 [ Schizosaccharomyces pombe (fission yeast) ]

    Gene ID: 2539090, updated on 18-Sep-2024

    Summary

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    Official Symbol
    pku70
    Official Full Name
    Ku domain protein Pku70
    Primary source
    PomBase:SPCC126.02c
    Locus tag
    SPOM_SPCC126.02C
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Schizosaccharomyces pombe (strain: 972h-)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Taphrinomycotina; Schizosaccharomycetes; Schizosaccharomycetales; Schizosaccharomycetaceae; Schizosaccharomyces
    Also known as
    ku70
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    Genomic context

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    See pku70 in Genome Data Viewer
    Location:
    chromosome: III
    Exon count:
    7
    Sequence:
    Chromosome: III; NC_003421.2 (2117095..2119663, complement)

    Chromosome III - NC_003421.2Genomic Context describing neighboring genes Neighboring gene ncRNA Neighboring gene uncharacterized protein Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene tRNA/U2 snRNA pseudouridine synthase Lsp1

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003421.2

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Microhomology-mediated end joining in fission yeast is repressed by pku70 and relies on genes involved in homologous recombination. Decottignies A. Genetics, 2007 Jul. PMID 17483423, Free PMC Article
    2. Novel functional requirements for non-homologous DNA end joining in Schizosaccharomyces pombe. Manolis KG, et al. EMBO J, 2001 Jan 15. PMID 11226171, Free PMC Article
    3. Schizosaccharomyces pombe KAT5 contributes to resection and repair of a DNA double-strand break. Li T, et al. Genetics, 2021 May 17. PMID 33723569, Free PMC Article
    4. Telomeric DNA ends are essential for the localization of Ku at telomeres in fission yeast. Miyoshi T, et al. J Biol Chem, 2003 Jan 17. PMID 12424244
    5. Protection of telomeres by the Ku protein in fission yeast. Baumann P, et al. Mol Biol Cell, 2000 Oct. PMID 11029034, Free PMC Article

    See all (35) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. These results suggest the possibility that Ku proteins (pku70, pku80)play an important role in genome integrity recovering replication stress.
      Title: Fission yeast Ku protein is required for recovery from DNA replication stress.
    2. potential relevance of Bin1-Ku interaction to cancer are discussed in light of these findings
      Title: Bin1 interacts with and restrains the DNA end-binding protein complex Ku.
    3. Pku70 inhibited microhomology-mediated end-joining and increased the minimal homology length required for efficient microhomology-mediated end-joining
      Title: Microhomology-mediated end joining in fission yeast is repressed by pku70 and relies on genes involved in homologous recombination.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by PomBase

    Function Evidence Code Pubs
    enables 3'-5' DNA helicase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables ATP hydrolysis activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables damaged DNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    contributes_to double-stranded DNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables telomeric DNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables telomeric DNA binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in double-strand break repair via nonhomologous end joining IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in double-strand break repair via nonhomologous end joining IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in replication fork processing IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in stalled replication fork localization to nuclear periphery IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in telomere maintenance IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in telomere maintenance IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    part_of Ku70:Ku80 complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in chromosome, subtelomeric region IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in chromosome, telomeric repeat region IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in heterochromatin IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in nucleus HDA PubMed 
    is_active_in nucleus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in pericentric heterochromatin IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in site of double-strand break IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    Ku domain protein Pku70
    NP_001342782.1
    • Ku70 (human XRCC6 ortholog) Pku70

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003421.2 Reference assembly

      Range
      2117095..2119663 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001355945.2 → NP_001342782.1  Ku domain protein Pku70 [Schizosaccharomyces pombe]

      Status: PROVISIONAL

      UniProtKB/Swiss-Prot
      O94395
      Conserved Domains (2) summary
      cd00788
      Location:234 → 514
      KU70; Ku-core domain, Ku70 subfamily; Ku70 is a subunit of the Ku protein, which plays a key role in multiple nuclear processes such as DNA repair, chromosome maintenance, transcription regulation, and V(D)J recombination. The mechanism underlying the ...
      cl25384
      Location:16 → 605
      Ku_C; Ku70/Ku80 C-terminal arm
    Nucleotide Protein
    Heading Accession and Version

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    Research Materials