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    OM14 Om14p [ Saccharomyces cerevisiae S288C ]

    Gene ID: 852531, updated on 28-Oct-2024

    Summary

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    Official Symbol
    OM14
    Official Full Name
    Om14p
    Primary source
    SGD:S000000434
    Locus tag
    YBR230C
    See related
    AllianceGenome:SGD:S000000434; FungiDB:YBR230C; VEuPathDB:YBR230C
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Summary
    Enables nascent polypeptide-associated complex binding activity. Involved in protein targeting to mitochondrion and ribosome localization. Located in mitochondrial inner-outer membrane contact site and mitochondrial outer membrane. [provided by Alliance of Genome Resources, Oct 2024]
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    Genomic context

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    See OM14 in Genome Data Viewer
    Location:
    chromosome: II
    Exon count:
    2
    Sequence:
    Chromosome: II; NC_001134.8 (679549..680050, complement)

    Chromosome II - NC_001134.8Genomic Context describing neighboring genes Neighboring gene endonuclease Neighboring gene glucan 1,3-alpha-glucosidase ROT2 Neighboring gene Coq21p Neighboring gene ncRNA

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001134.8

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. The multi-factor modulated biogenesis of the mitochondrial multi-span protein Om14. Zhou J, et al. J Cell Biol, 2022 Apr 4. PMID 35262629, Free PMC Article
    2. The presequence pathway is involved in protein sorting to the mitochondrial outer membrane. Wenz LS, et al. EMBO Rep, 2014 Jun. PMID 24781695, Free PMC Article
    3. OM14 is a mitochondrial receptor for cytosolic ribosomes that supports co-translational import into mitochondria. Lesnik C, et al. Nat Commun, 2014 Dec 9. PMID 25487825, Free PMC Article
    4. Genome-Wide Screens in Saccharomyces cerevisiae Highlight a Role for Cardiolipin in Biogenesis of Mitochondrial Outer Membrane Multispan Proteins. Sauerwald J, et al. Mol Cell Biol, 2015 Sep. PMID 26149385, Free PMC Article
    5. The UbiB family member Cqd1 forms a novel membrane contact site in mitochondria. Khosravi S, et al. J Cell Sci, 2023 May 15. PMID 37073556, Free PMC Article

    See all (43) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. The multi-factor modulated biogenesis of the mitochondrial multi-span protein Om14.
      Title: The multi-factor modulated biogenesis of the mitochondrial multi-span protein Om14.
    2. OM14 is a mitochondrial receptor for cytosolic ribosomes that supports co-translational import into mitochondria
      Title: OM14 is a mitochondrial receptor for cytosolic ribosomes that supports co-translational import into mitochondria.
    3. Saccharomyces cerevisiae porin pore forms complexes with mitochondrial outer membrane proteins Om14p and Om45p.
      Title: Saccharomyces cerevisiae porin pore forms complexes with mitochondrial outer membrane proteins Om14p and Om45p.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables nascent polypeptide-associated complex binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables nascent polypeptide-associated complex binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables nascent polypeptide-associated complex binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in protein targeting to mitochondrion IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in protein targeting to mitochondrion IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in ribosome localization IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in mitochondrial inner-outer membrane contact site IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    is_active_in mitochondrial outer membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in mitochondrial outer membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in mitochondrial outer membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in mitochondrion HDA PubMed 
    located_in mitochondrion IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    Om14p
    NP_009789.1
    • Mitochondrial outer membrane receptor for cytosolic ribosomes; integral protein of the outer membrane that interacts with the nascent chain-associated complex (NAC) bound to ribosomes, contributing to co-translational mitochondrial import; interacts with porin (Por1p) and Om45p; abundance is decreased in cells grown in glucose relative to other carbon sources

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001134.8 Reference assembly

      Range
      679549..680050 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001178578.1 → NP_009789.1  TPA: Om14p [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_009789.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      A6ZLG8, D6VQM5, P38325
      UniProtKB/TrEMBL
      B3LMT3, D3UEX6, G2W9N2, N1P8Q5
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P38325.1

    Gene LinkOut

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